Myeloid Proliferation
Mostrando 13-24 de 209 artigos, teses e dissertações.
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13. Alterações Eritropoéticas e Leucopoéticas na Leishmaniose Visceral Canina
The bone marrow is considered an important reservoir of parasites in sick Leishmania-infected dogs. Little is know about the process cellular genesis in bone marrow in Canine Visceral Leishmaniasis (CVL) presenting different clinical status. In this context, the aim of the present study was to evaluate leucopoiesis and erythropoiesis alterations as well as t
Publicado em: 2008
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14. JAK2 V617F prevalence in Brazilian patients with polycythemia vera, idiopathic myelofibrosis and essential thrombocythemia
Polycythemia vera (PV), essential thrombocythemia (ET) and idiopathic myelofibrosis (IMF) are myeloproliferative disorders (MPD) that arise from the clonal proliferation of a pluripotent hematopoietic progenitor, leading to the overproduction of one or more myeloid lineages. Recently, a specific mutation in the JAK2 gene, which encodes a tyrosine kinase, has
Genetics and Molecular Biology. Publicado em: 2007-03
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15. Expression of active BCR related (ABR) gene in chronic myeloid leukemia (CML) real-time RT-PCR (qPCR) / Estudo da expressão do Gene ABR em leucemia mieloide cronica (LMC) utilizando real-time RT-PCR (qPCR)
Chronic myeloid leukemia (CML) is a clonal proliferative disorder of the hematopoietic stem cell cytogenetically characterized by the Philadelphia (Ph) chromosome, a result of chromosomal translocation t(9;22)(q34;q11). At molecular level, the Ph chromosome results in a fusion gene, the chimerical BCR-ABL which has constitutive tyrosine kinase activity and i
Publicado em: 2006
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16. Perfil de expressão genica de leucemias agudas por tecnica de microarranjo (microarrays) / Study of gene expression profile in acute leukemias by microarray assay
The development of gene expression assays, such as cDNA microarrays, has permitted the simultaneous study of several genes; one of this methods is the cDNA microarrays. These investigations contribute to the classification of diseases, comprehension of tumoral biology and, finally, the determination of genetically related prognostic factors. In this present
Publicado em: 2006
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17. Reintroduction of CEBPA in MN1-overexpressing hematopoietic cells prevents their hyperproliferation and restores myeloid differentiation
Forced expression of MN1 in primitive mouse hematopoietic cells causes acute myeloid leukemia and impairs all-trans retinoic acid-induced granulocytic differentiation. Here, we studied the effects of MN1 on myeloid differentiation and proliferation using primary human CD34+ hematopoietic cells, lineage-depleted mouse bone marrow cells, and bipotential (granu
American Society of Hematology.
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18. Engagement of p75/AIRM1 or CD33 inhibits the proliferation of normal or leukemic myeloid cells
P75/AIRM1 is a recently identified surface molecule that belongs to the sialoadhesin family and displays homology with the myeloid cell antigen CD33. In lymphoid cells, p75/AIRM1 is confined to natural killer cells and mediates inhibition of their cytolytic activity. In this study, we show that p75/AIRM1 is also expressed by cells of the myelomonocytic cell
The National Academy of Sciences.
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19. Surface expression and function of p75/AIRM-1 or CD33 in acute myeloid leukemias: Engagement of CD33 induces apoptosis of leukemic cells
p75/AIRM-1 is a recently identified inhibitory receptor expressed by natural killer and myeloid cells displaying high homology with CD33. Crosslinking of p75/AIRM-1 or CD33 has been shown to sharply inhibit the in vitro proliferation of both normal myeloid cells and chronic myeloid leukemias. In this study, we analyzed acute myeloid leukemic cells for t
The National Academy of Sciences.
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20. Vitamin D compounds. Effect on clonal proliferation and differentiation of human myeloid cells.
We examined the effect of 1 alpha,25-dihydroxyvitamin D3 (1 alpha,25(OH)2D3) and a variety of vitamin D analogs on proliferation and differentiation of normal and leukemic myeloid clonogenic cells. Only cells from myeloid leukemic lines that contained relatively mature cells (HL-60, U937, THP, HEL, M1) were induced to differentiate and were inhibited in thei
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21. Unregulated proliferation of primitive chronic myeloid leukemia progenitors in the presence of normal marrow adherent cells
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22. Interleukin 1 as an autocrine growth factor for acute myeloid leukemia cells.
Production of interleukin 1 (IL-1) by leukemic cells was studied in 13 cases of acute myeloid leukemia. Intracytoplasmic immunofluorescence studies showed that the cells invariably contained the cytokine. Endogenous labeling studies demonstrated that acute myeloid leukemia cells produced either only the 33-kDa propeptide or both the propeptide and the 17-kDa
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23. Mzf1 controls cell proliferation and tumorigenesis
MZF1 is a transcription factor belonging to the Krüppel family of zinc finger proteins, expressed in totipotent hemopoietic cells as well as in myeloid progenitors. Here we have inactivated Mzfi1 by gene targeting. Mzf1−/− mice develop lethal neoplasias characterized by the infiltration and complete disruption of the liver architecture by a monomorphic
Cold Spring Harbor Laboratory Press.
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24. Distinct cytoplasmic regions of the human granulocyte colony-stimulating factor receptor involved in induction of proliferation and maturation.
The granulocyte colony-stimulating factor receptor (G-CSF-R) transduces signals important for the proliferation and maturation of myeloid progenitor cells. To identify functionally important regions in the cytoplasmic domain of the G-CSF-R, we compared the actions of the wild-type receptor, two mutants, and a natural splice variant in transfectants of the mo