Mitotic Recombination
Mostrando 1-12 de 453 artigos, teses e dissertações.
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1. Gene homozygosis and mitotic recombination induced by camptothecin and irinotecan in Aspergillus nidulans diploid cells
A recombinação mitótica é um processo com participação na carcinogênese e com capacidade de induzir perda genética através da perda da heterozigosidade. Os potenciais recombinagênicos de duas drogas anticancerígenas, camptotecina (CPT) e irinotecan (CPT-11), caracterizadas como inibidores da DNA-Topoisomerase I, foram avaliados no presente estudo,
An. Acad. Bras. Ciênc.. Publicado em: 21/10/2014
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2. Análise da variação cariotípica e dos mecanismos de recombinação em leveduras industriais (Saccharomyces cerevisiae) durante o processo de fermentação alcoólica / Analysis of the karyotypic variation and the recombination mechanisms industrial yeast (Saccharomyces cerevisiae) during the alcoholic fermentation process
Brazilian sugar cane ethanol stands out among the energetic alternatives available nowadays. In the fermentation process to produce ethanol it is used the yeast Saccharomyces cerevisiae. One of the most widely adopted strains is the industrial isolate PE-2, currently used by ~30% of Brazilian distilleries, generating ~10% of the worlds ethanol supply. This
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 06/08/2010
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3. Diversidade genética em populações de Plasmodium vivax: análise de marcadores genéticos neutros e de genes potencialmente associados à resistência a drogas. / Genetic diversity of Plasmodium vivax populations: analysis of neutral genetic markers and genes potentially associated with drug resistance.
Through the analysis of microsatellites and SNPs, including both neutral and under selection markers, this work showed that: 1) The Brazilian populations of P. vivax (Pv) are more diverse than sympatric P. falciparum (Pf) populations, but both exhibit linkage disequilibrium. 2) For both species, neutral polymorphisms showed high variability over time, contra
Publicado em: 2010
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4. Genotoxic effect of alkaloids
Because of the increased use of alkaloids in general medical practice in recent years, it is of interest to determine genotoxic, mutagenic and recombinogenic response to different groups of alkaloids in prokaryotic and eucaryotic organisms. Reserpine, boldine and chelerythrine did not show genotoxicity response in the SOS-Chromotest whereas skimmianine showe
Publicado em: 2010
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5. Protection by Panax ginseng C.A. Meyer against the genotoxicity of doxorubicin in somatic cells of Drosophila melanogaster
Panax ginseng is one of the most widely prescribed herbal medicines for the treatment of cancer, diabetes, chronic inflammation, and neurodegenerative and cardiovascular diseases. Since the use of alternative medicines in combination with conventional therapy may increase the risk of unwanted interactions, we investigated the possible genotoxicity of a water
Genetics and Molecular Biology. Publicado em: 2008-12
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6. Impacto genotÃxico de poluentes quÃmicos presentes na Ãgua e sedimento do Rio Japaratuba (Sergipe)
In situ investigations of the effects of mutagenic pollutants (environmental monitoring) have increasingly used bioindicators, and fish often have been used in these studies as sentinel organisms. In the present study, we have used the piscine micronucleus test (MNT) as an in situ biological indicator of chemical contamination in two fresh water fish species
Publicado em: 2006
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7. Benznidazole-induced genotoxicity in diploid cells of Aspergillus nidulans
Genotoxic effects of benznidazole were studied by the induction of homozygosis of genes previously present in heterozygous. UT448//A757 diploid strain was used in the benznidazole's recombinagenesis test. Although toxic effects on growth of colonies were not observed, 75 and 100 µM benznidazole induced an increasing of mitotic recombination events in diploi
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-05
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8. Cremophor EL stimulates mitotic recombination in uvsH//uvsH diploid strain of Aspergillus nidulans
Cremofor EL (CEL) é um solubilizante e emulsificante amplamente utilizado nas indústrias farmacêuticas e de gêneros alimentícios. É o principal veículo empregado nas formulações clínicas do antineoplásico paclitaxel. Considerando-se que a recombinação mitótica desempenha importante função no processo de carcinogênese, o estudo de substância
Anais da Academia Brasileira de Ciências. Publicado em: 2004-03
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9. Increase in mitotic recombination in diploid cells of Aspergillus nidulans in response to ethidium bromide
Ethidium bromide (EB) is an intercalating inhibitor of topoisomerase II and its activities are related to chemotherapeutic drugs used in anti-cancer treatments. EB promotes several genotoxic effects in exposed cells by stabilising the DNA-enzyme complex. The recombinagenic potential of EB was evaluated in our in vivo study by the loss of heterozygosity of nu
Genetics and Molecular Biology. Publicado em: 2003
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10. Genetic and cytological characterization of the somatic recombination in Trichoderma pseudokoningii. / Caracterização genética e citológica da recombinação somática em Trichoderma pseudokoningii.
Com o objetivo de se caracterizar o processo de recombinação somática em Trichoderma pseudokoningii foram feitos cruzamentos via anastomose de hifas entre duas linhagens contrastantes para quatro marcadores de auxotrofia, coloração dos conídios e marcadores de RAPD. Foram feitos quatro cruzamentos, sendo analisados um total de 1052 colônias obtidas a
Publicado em: 2002
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11. The genetic study of sterigmatocystin production in Aspergillus nidulans. / Estudo genético da produção de esterigmatocistina em Apergillus nidulans.
Sterigmatocystin (ST) is a polyketide produced by different species of Aspergillus as well as by other fungus genera such as Bipolaris and Chaetomium. This toxin is characterized as a bifuranoxanthone, whose molecular formula is C18H12O6 and which is frequently found as a contaminant in several food products such as oil-seed grains and cereals. It has carcin
Publicado em: 1999
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12. Isolation and Characterization of Schizosaccharomyces Pombe Mutants Affected in Mitotic Recombination
A haploid Schizosaccharomyces pombe strain carrying a heteroallelic duplication of the ade6 gene was used to isolate mitotic recombination-deficient mutants. Recombination between the different copies of the ade6 gene can lead to Ade(+) segregants. These are observed as growing papillae when colonies of a suitable size are replicated onto selective medium. W