Diversidade genética em populações de Plasmodium vivax: análise de marcadores genéticos neutros e de genes potencialmente associados à resistência a drogas. / Genetic diversity of Plasmodium vivax populations: analysis of neutral genetic markers and genes potentially associated with drug resistance.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2010

RESUMO

Through the analysis of microsatellites and SNPs, including both neutral and under selection markers, this work showed that: 1) The Brazilian populations of P. vivax (Pv) are more diverse than sympatric P. falciparum (Pf) populations, but both exhibit linkage disequilibrium. 2) For both species, neutral polymorphisms showed high variability over time, contrasting with the stability of under markers under selection. 3) The high rate of Pv recurrences in the Brazilian Amazon region is mostly due to genetically unrelated parasites. 4) Non-meiotic recombination substantially contributes to PvCSP repetitive domain diversity. 5) SNPs at pvmdr1 and pvcrt-o genes of chloroquine resistant isolates of Pv are not associated with the in vivo phenotype. Finally, 57 SNP genotyping of chromosome 8 of Pv among 234 isolates from Brazil and Asia showed that, in Pv, diversity and mitotic recombination are not associated with levels of endemicity as in Pf and that Pv presents continental population structure and subcontinental structure in Brazil.

ASSUNTO(S)

genetic recombination genetic variation malaria malária marcador molecular molecular marker recombinação genética resistance resistência variação genética

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