Microbicidal Function
Mostrando 1-12 de 58 artigos, teses e dissertações.
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1. Culture of mouse peritoneal macrophages with mouse serum induces lipid bodies that associate with the parasitophorous vacuole and decrease their microbicidal capacity against Toxoplasma gondii
Lipid bodies [lipid droplets (LBs)] are lipid-rich organelles involved in lipid metabolism, signalling and inflammation. Recent findings suggest a role for LBs in host response to infection; however, the potential functions of this organelle in Toxoplasma gondii infection and how it alters macrophage microbicidal capacity during infection are not well unders
Mem. Inst. Oswaldo Cruz. Publicado em: 13/08/2014
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2. Production of TNF-α, nitric oxide and hydrogen peroxide by macrophages from mice with paracoccidioidomycosis that were fed a linseed oil-enriched diet
Omega-3 polyunsaturated fatty acids (n-3 PUFA) can modulate the immune system and their primary effect is on macrophage function. Paracoccidioidomycosis (PCM) is an endemic systemic mycosis in Latin America that is caused by the dimorphic fungus Paracoccidioides brasiliensis (Pb). Macrophages are the main defence against this pathogen and have microbicidal a
Memórias do Instituto Oswaldo Cruz. Publicado em: 2012-05
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3. Characterization of the actions of Crotalus durissus terrificus venon on neutrophils functions / Caracterização das ações do veneno de Crotalus durissus terrificus sobre funções de neutrófilos
Previous studies showed that Crotalus durissus terrificus snake venom (CdtV) has long-lasting anti-inflammatory properties and inhibits the spreading and the phagocytic activity of peritoneal macrophages. Crotoxin (CTX), the main component of CdtV, is responsible for these effects. In addition, CdtV inhibits, in vitro and in vivo, the phagocytic activity of
Publicado em: 2010
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4. The relationship between the cellular location of Leishmania (Leishmania) amazonensis arginase and its role during murine macrophage infection / Relação entre a localização celular da enzima arginase de Leishmania (Leishmania) amazonensis e seu papel na infecção de macrófagos murinos
In the mammal host, Leishmania parasites live inside macrophages escaping from their microbicidal mechanisms, such as the nitric oxide (NO) production. The macrophage NO production by inducible nitric oxide synthase (iNOS) requires L-arginine as substrate, the same amino acid required by arginase to generate ornithine and urea. So, arginase may play a dual r
Publicado em: 2010
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5. A função da IL-10 na paracoccidioidomise pulmonar murina. / The role of IL-10 in murine pulmonary paracoccidioidomycosis.
Cellular immunity is the main defense mechanism of hosts infected by the Paracoccidioide brasiliensis (Pb), a dimorphic fungus that causes the most important systemic mycosis in Latin America. IFN-g activated macrophages participate in this activity that is antagonized by IL-10 an anti-inflammatory cytokine. Both, in the human pathology a
Publicado em: 2010
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6. FunÃÃo microbicida de macrÃfagos alveolares de ratos submetidos à desnutriÃÃo neonatal: estudo da infecÃÃo celular, in vitro, por Staphylococcus aureus meticilina sensÃvel e meticilina resistente
Staphylococcus aureus resistant to methicillin have increased significantly in recent years, and is a major public health problem, like is malnutrition, still presents in our country. Therefore it is important to evaluate effects of malnutrition in the neonatal immune response against potential pathogens such as S. aureus. Male Wistar rats were breastfed by
Publicado em: 2009
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7. Neutrophil function and metabolism in individuals with diabetes mellitus
Neutrophils act as first-line-of-defense cells and the reduction of their functional activity contributes to the high susceptibilityto and severity of infections in diabetes mellitus. Clinical investigations in diabetic patients and experimental studies in diabetic rats and mice clearly demonstrated consistent defects of neutrophil chemotactic, phagocytic an
Brazilian Journal of Medical and Biological Research. Publicado em: 05/07/2007
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8. Avaliação da função neutrofílica em indivíduos infectados pelo HTLV-I. / Evaluation of the neutophil function in HTLV-I Infected individuals.
Human T-cell lymphotropic virus-type I (HTLV-I) induces activation and spontaneous proliferation of T cells with production of type-I pro-inflammatory cytokines (IFN-γ and TNF-α). However, little is known about the innate immune response in HTLV-I infection. HTLV-I infected individuals have higher spontaneous neutrophil activation than HTLV-I seron
Publicado em: 2007
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9. The use of reverse transcription-PCR for the diagnosis of X-linked chronic granulomatous disease
Chronic granulomatous disease (CGD) is an inherited disorder of the innate immune system characterized by a defective oxidative burst of phagocytes and subsequent impairment of their microbicidal activity. Mutations in one of the NADPH-oxidase components affect gene expression or function of this system, leading to the phenotype of CGD. Defects in gp91-phox
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-05
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10. Cissampelos sympodialis Eichl (Menispermaceae) leaf extract induces interleukin-10-dependent inhibition of Trypanosoma cruzi killing by macrophages
The aqueous fraction of the ethanolic extract (AFL) of Cissampelos sympodialis Eichl (Menispermaceae), popularly known as milona, has been shown to have both immunosuppressive and anti-inflammatory effects. In the present study we investigated the modulation of macrophage antimicrobicidal activity by in vitro treatment with the extract from C. sympodialis. N
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-02
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11. Comparison of the effects of filtration leucapheresis and discontinuous flow centrifugation leucapheresis on granulocyte microbicidal function.
In an investigation of the in vitro phagocytic and microbicidal function of granulocytes collected by filtration leucapheresis (FL) from 18 donors and by discontinuous flow centrifugation leucapheresis (DFC) from six donors, comparison was made with the function of granulocytes obtained from the same donors by venepuncture and density gradient centrifugation
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12. Defective neutrophil function and microbicidal mechanisms in the myelodysplastic disorders.
Neutrophil function studies have been carried out in a series of 44 patients with primary myelodysplastic syndromes (MDS). In vitro tests of phagocytosis and killing of Candida guilliermondii and Staphylococcus aureus identified 13 patients with abnormal neutrophil function at presentation and a further 10 who developed abnormalities during the course of the