Mice Ob Ob
Mostrando 1-12 de 143 artigos, teses e dissertações.
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1. Effect of co-administration of BRL-37344 and tadalafil on reduction of overactive bladder symptoms after induction of detrusor overactivity in mice
Abstract Purpose: To evaluate the impact of the combination of BRL 37344 and tadalafil (TDF) on the reduction of overactive bladder (OB) symptoms. Methods: Thirty mice were randomized into 5 groups (G) of 6 animals each. L-NAME was used to induce DO. G1: Control; G2: L-NAME; G3: L-NAME + TDF; G4: L-NAME + BRL 37344; G5: L-NAME + TDF + BRL 37344. After 30
Acta Cir. Bras.. Publicado em: 28/02/2019
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2. The testis of the mice C57/BL6 offspring in adulthood have alterations due to maternal caffeine consumption
PURPOSE: To investigate the effects of the maternal caffeine consumption during pregnancy to adult male testis mice offspring. METHODS: Twenty pregnant mice were divided into control group (c) and caffeine group (cf). dams received daily saline or 20 mg/kg of caffeine subcutaneously. Male offspring were monitored daily until 13th week. The testis were
Acta Cir. Bras.. Publicado em: 2014-01
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3. Papel da neurogênese nos efeitos promnésicos do ambiente enriquecido sobre a memória social
Social memory comprehends the information necessary to identify and recognize co-specifics. This kind of memory is essential in many forms of social interaction and is modulated by the environmental conditions. Previous studies from our laboratory showed that social isolation impairs the social memory persistence and that enriched environment (EE) prevents t
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/03/2012
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4. Effects of oral administration of S-nitrosothiols and knectic evaluation of the kinetic propensity and resistance to diet induced obessity / Efeitos da administração orogástrica de s-nitrosotióis e avaliação cinética da propensão e resistência à obsidade induzida por dieta
In the present study, the nitric oxide (NO)-associated physiological actions obtained topically on the gastric mucosa and systemically in oral administrations of two NO donors-S-nitrosothiols (RSNOs), S-nitrosoglutathione (GSNO) and S-nitroso-N-acetylcysteine (SNAC) were investigated in animal models. The topical ex vivo administration of RSNOs solutions on
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/07/2011
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5. Morfoquantitative and chemical coding analyses of the purinergic P2X2 receptor in myenteric plexus of female and male obese mice (ob/ob). / Análises morfoquantitativa e do código químico do receptor purinérgico P2X2 no plexo mioentérico do íleo de camundongos obesos fêmeas e machos (ob/ob).
The intestinal activities are coordinated by enteric nervous system, and dysfunctions in intestinal motility were observed in obese individuals. The enteric neurons have been demonstrated to express different purinergics receptors. This study aims to analyze the expression of P2X2 receptor and the chemical code in the myenteric neurons in obesity. Sample fro
Publicado em: 2010
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6. Evaluation of Yo Jyo Hen Shi Ko (YHK) in hepatic lipid metabolism in experimental steatohepatitis / Efeito do Yo Jyo Hen Shi Ko (YHK) no metabolismo lipídico na esteatohepatite experimental
A Doença Hepática Gordurosa Não Alcoólica (DHGNA) é atualmente uma das formas mais comuns de doença hepática, e está diretamente relacionada com a obesidade. Estudos indicam uma prevalência por volta de 30% na população ocidental e 11% na população oriental. A DGHNA possui um largo espectro abrangendo desde casos de esteatose simples sem inflama
Publicado em: 2010
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7. Produção e caracterização de leptina e TcPTP1 recombinantes, proteínas ligadas ao metabolismo, sinalização celular e inflamação. / Production and characterization of recombinant leptin and TcPTP1, proteins linked to metabolism, cell sinalization and inflamation.
Leptin is predominantly secreted by adipocytes and plays an important role in the regulation of the energetic metabolism of mammals. Because of this, leptin is strongly involved in the regulation of obesity. After ligation, dimerization and activation of its specific receptor in the hypothalamus, leptin activates JAK kinases that phosphorylate STAT transcrip
Publicado em: 2010
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8. Efeitos da obesidade no sistema calicreína-cininas: estudo dos receptores b1 e b2 de cininas em tecido adiposo humano e murino. / Obesity, Leptin and Renin-Angiotensin System: Role on blood pressure control and autonomic regulation in ob/ob and db/db mice.
The leptin deficient ob/ob mice are insulin resistant and obese. However, the control of blood pressure in this model is not well defined. The goal of this study was to evaluate the role of leptin and the renin-angiotensin system (RAS) in the cardiovascular abnormalities observed in obesity using a model lacking leptin. Leptin is a hormone related to metabol
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/08/2009
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9. Determinação do limiar de lactato e do máximo estado estável de lactato em comundongos ob/ob na natação
Obesity is a chronic metabolic disturb of multiple ethiology and a high prevalence worldwide. It is also associated to several diseases. One type of non-pharmachological treatment of obesity is the physical exercise. Although many researchers have been performed in animal models, there is a lack in the literature of studies analyzing aerobic capacity assessm
Publicado em: 2009
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10. Esteato-hepatite não alcoólica (ENA) em camundongos obesos (ob/ob): avaliação do efeito citoprotetor do Yo Jyo Hen Shi Ko (YHK) / YO JYO HEN SHI KO, a novel Chinese herbal, prevents nonalcoholic steatohepatitis in ob/ob mice fed a high fat or methionine/choline deficient diet
Background: Oxidative stress plays a role in the pathogenesis of nonalcoholic steatohepatitis (NASH). Yo Jyo Hen Shi Ko (YHK) is a complex compound purported to reduce reactive oxygen species (ROS) by blocking the propagation of radical-induced reactions. Aim: The aim of this study was to evaluate the role of the effect of YHK in experimental NASH. Methods:
Publicado em: 2007
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11. Schistosomal granuloma as a system adaptive complex. Application of fractal dimension in characterization of their geometric properties. / Granuloma esquistossomótico como um sistema adaptativo complexo. Aplicação da dimensão fractal na caracterização de suas propriedades geométricas.
Schistosomal granuloma AS A COMPLEX ADAPTIVE SYSTEM: APPLICATION OF FRACTAL DIMENSION IN THE CHARACTERIZATION OF PROPERTIES GEOMETRIC. Waldemiro de Souza Romagna. [Introduction]. The schistosomal granuloma is a compact, organized collection of migrating cells, which along with cells of the affected organ, arrange themselves in the midst of extracellular matr
Publicado em: 2007
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12. Decreased food intake does not completely account for adiposity reduction after ob protein infusion.
The effects of recombinantly produced ob protein were compared to those of food restriction in normal lean and genetically obese mice. Ob protein infusion into ob/ob mice resulted in large decreases in body and fat-depot weight and food intake that persisted throughout the study. Smaller decreases in body and fat-depot weights were observed in vehicle-treate