Major Histocompatibility Complex Genetics
Mostrando 1-12 de 21 artigos, teses e dissertações.
1. Estudo do poliformismo genético na hepatite auto-imune na infância: busca de genes e haplótipos de suscetibilidade / Study of genetic polymorphism in children: searching for susceptibility genes and haplotypes
A hepatite auto-imune (HAI) é uma doença inflamatória crônica do fígado, de etiologia desconhecida, que acomete preferencialmente mulheres, com destruição progressiva do parênquima hepático e que, sem tratamento imunossupressor, evolui freqüentemente para cirrose. É uma doença rara na infância, com menos de 10% dos pacientes com doença hepátic
Publicado em: 2008
2. Hunting expressed mammary gland genes related to mastitis in dairy cattle / Descobrindo genes expressos na glândula mamária e relacionados à ocorrência e controle da mastite bovina
Brazil is the largest cattle commercial herd in the world, mainly based in zebu (Bos indicus) with lower genetic potential than taurus-derived animals. Molecular genetics brought the possibility of better selection of animals for breeding, which increases production levels. The use of molecular methods for studying genetic variation is especially advantageou
Publicado em: 2003
3. Allelic and nonallelic homology of a supergene family.
A model to explain the high degree of polymorphism at the major histocompatibility complex (MHC) is described. The model incorporates domain transfer between the different loci in a supergene family by either gene conversion or double unequal crossing-over. Population genetics theory is used to formulate changes in the probabilities of allelic and nonallelic
4. Murine major histocompatibility complex and immune response to Eimeria falciformis.
The genetics of the immune response to Eimeria falciformis were investigated in three inbred and six congenic strains of mice. There were significant differences among strains in oocyst production and age-related mortality from parasitic infection. Genes within the H-2 complex and also non-H-2 genes share in the immune response to eimerian infection.
5. The molecular genetics of human chromosome 6.
Chromosome 6 contains several clinically important markers as well as classical enzyme loci, proto-oncogenes, and a growing number of anonymous DNA restriction fragment length polymorphisms (RFLPs). It is also of unique interest because of the location of the major histocompatibility complex (MHC) on the short arm, at 6p21.3. The MHC is one of the most detai
6. Linkage disequilibrium due to random genetic drift in finite subdivided populations
In order to clarify the mechanisms responsible for the observed linkage disequilibrium, such as that found between markers in the major histocompatibility complex of man and mouse, linkage disequilibrium between two linked loci was studied for a finite population with a subdivided structure. The infinite allele model was used. In analogy with the subdivision
7. Genetics of resistance to African trypanosomes: role of the H-2 locus in determining resistance to infection with Trypanosoma rhodesiense.
Susceptibility and resistance to Trypanosoma rhodesiense infections in inbred and H-2 congenic strains of mice were studied. Mean survival times and patterns of parasitemia were examined. C3HeB/FeJ mice were highly susceptible; CBA/J, A/J, and BALB/cByJ mice displayed an intermediate level of susceptibility; whereas C57BL/10 mice were highly resistant. H-2 c
8. Antigenic Diversity in Eimeria maxima and the Influence of Host Genetics and Immunization Schedule on Cross-Protective Immunity
Eimeria spp. are a group of highly successful intracellular protozoan parasites that develop within enterocytes. Eimeria maxima from the chicken is characterized by high immunogenicity (a small priming infection gives complete immunity to subsequent homologous challenge) and naturally occurring antigenically variant populations that do not completely cross-p
American Society for Microbiology.
9. Determining the One, Two, Three, or Four Long and Short Loci of Human Complement C4 in a Major Histocompatibility Complex Haplotype Encoding C4A or C4B Proteins
The complex genetics of human complement C4 with unusually frequent variations in the size and number of C4A and C4B, as well as their neighboring genes, in the major histocompatibility complex has been a hurdle for accurate epidemiological studies of diseases associated with C4. A comprehensive series of novel or improved techniques has been developed to de
The American Society of Human Genetics.
10. Molecular characterization of novel H-2 class I molecules expressed by a C3H UV-induced fibrosarcoma.
Two novel class I-like molecules expressed on tumor 1591, a C3H UV-induced fibrosarcoma, are biochemically characterized using two-dimensional gel electrophoresis, a cross-blocking RIA, and tryptic peptide mapping. One novel molecule that reacts with CP28, a syngeneic tumor-specific monoclonal antibody, appears mosaic because it possesses characteristics of
11. Immunity to retroviral infection: The Friend virus model
Friend virus infection of adult immunocompetent mice is a well established model for studying genetic resistance to infection by an immunosuppressive retrovirus. This paper reviews both the genetics of immune resistance and the types of immune responses required for recovery from infection. Specific major histocompatibility complex (MHC) class I and II
National Academy of Sciences.
12. Molecular genetics of speciation and human origins.
The major histocompatibility complex (MHC) plays a cardinal role in the defense of vertebrates against parasites and other pathogens. In some genes there are extensive and ancient polymorphisms that have passed from ancestral to descendant species and are shared among contemporary species. The polymorphism at the DRB1 locus, represented by 58 known alleles i