Genetics of resistance to African trypanosomes: role of the H-2 locus in determining resistance to infection with Trypanosoma rhodesiense.

AUTOR(ES)

Levine, R F

RESUMO

Susceptibility and resistance to Trypanosoma rhodesiense infections in inbred and H-2 congenic strains of mice were studied. Mean survival times and patterns of parasitemia were examined. C3HeB/FeJ mice were highly susceptible; CBA/J, A/J, and BALB/cByJ mice displayed an intermediate level of susceptibility; whereas C57BL/10 mice were highly resistant. H-2 congenic strains with the BL/10 background resembled the BL/10 parental type, thereby suggesting that the major histocompatibility complex does not play a major role in regulating resistance and susceptibility to infection with T. rhodesiense.

Documentos Relacionados

• H-2 linkage control of resistance to subcutaneous infection with Mycobacterium lepraemurium.
• Differential susceptibility to DL-alpha-difluoromethylornithine in clinical isolates of Trypanosoma brucei rhodesiense.
• Trypanosoma rhodesiense infection in mice: sex dependence of resistance.
• Characterization of the genes specifying two metacyclic variable antigen types in Trypanosoma brucei rhodesiense.
• Influence of H-2 and non-H-2 genes on resistance to murine cytomegalovirus infection.