Kinins
Mostrando 1-12 de 48 artigos, teses e dissertações.
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1. Influência da deleção genética de receptores de cininas no metabolismo de óxido nítrico vascular / Influence of targeted deletion of kinins receptors in the vascular nitric oxide metabolism.
A ativacao de receptores B1 de cininas no endotelio vascular desencadeia vias de sinalizacao que resultam na elevacao do Ca+2 intracelular e ativacao da enzima oxido nitrico sintase (NOS), seguido por producao de NO e vasodilatacao. Embora a inducao do receptor B1 e sua funcao durante a inflamacao tenha sido abordada por diversos estudos, a importancia de re
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/09/2011
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2. Indução de receptor B1 de cininas em vasos sanguineos de ratos hipertensos por infusão de angiotensina II: estudo molecular e funcional. / Induction of kinin B1 receptor in blood vessels of angiotensin II-hypertensive rats: molecular and functional studies
O objetivo deste estudo foi avaliar se a infusão de angiotensina II (ANG II) modulava a expressão do receptor B1 (RB1) de cininas em aorta (AO),arteríolas mesentéricas (AM) de ratos Wistar e também verificar a influência do RB1 na pressão arterial e reatividade desses vasos sanguíneos através do agonista de RB1, DABK. Os ratos receberam por 28 dias
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/04/2011
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3. Papel dos receptores B1 e B2 de bradicinina e de captopril nas interações célula hospedeira-Trypanosoma cruzi
The infection of monocytes by Trypanosoma cruzi tripomastigotes is a crucial step for the development of Chagas disease immune response. Infection by T. cruzi has demonstrated to be an active process, involving diverse cellular components and different cell types. Previous studies of the interaction tissue-culture derived trypomastigotes (TCT) between cardio
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/08/2010
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4. Efeito anti-inflamatório do óleo essencial de Croton zehntneri pax et hofmm e do Anetol. / Anti-inflammatory effect of essential oil of Croton et pax zehntneri hofmm and Anethole.
Essential oils from the gender Croton (Euphorbiaceae) are sources of bioactive molecules, from which are obtained several compounds of diverse chemical groups and great therapeutic potential in folk medicine. The essential oil of Croton zehntneri (EOCz), popularly known as Canela-de-Cunhã, possesses anethole, estragole and eugenol as the main constituents.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/06/2009
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5. Disfunção cardíaca em animal nocaute para o receptor do tipo 2 para bradicinina
The Kinins are important peptides concerning control of cardiovascular function. Their action mechanism depend on the activation of two distinct receptor, type 1 and 2 bradykinin receptor (B1R and B2R). They both are coupled to G protein, which are responsible to activate different intracellular pathways, involved in different cellular process. Their role in
Publicado em: 2009
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6. Role of angiotensin-I converting enzyme in the regulation of the hematopoietic response normal and kinin receptor B1 kockout mice. / Papel da enzima conversora de angiotensina-I na regulação hematopoética de animais normais e nocautes dos receptores B1 de cininas.
Evidências sobre a presença do sistema renina-angiotensina (SRA) na medula óssea e a possível participação da enzima conversora de angiotensina-I (ECA) na regulação hematopoética tem despertado o interesse da comunidade científica. Como a ECA também é um componente chave do sistema calicreína-cininas (SCC), é possível que elementos deste siste
Publicado em: 2008
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7. Local alterations induced by the toxic secretion of Philodryas patagoniensis (Serpentes: Colubridae) / Alterações locais induzidas pela secreção tóxicas de Philodryas patagoniensis (Girard, 1857) (Serpentes: Colubridae)
The venom of Philodryas patagoniensis causes important and similar local lesions the ones that happen in the botropic accidents. The mechanisms involved in the local actions of this venom are little known. This study has as objective investigates the morphologic and inflammatory local actions of the venom of Philodryas patagoniensis and the mechanisms involv
Publicado em: 2008
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8. Functional expression of kinin B1 and B2 receptors in mouse abdominal aorta
Previous studies have shown that the vascular reactivity of the mouse aorta differs substantially from that of the rat aorta in response to several agonists such as angiotensin II, endothelin-1 and isoproterenol. However, no information is available about the agonists bradykinin (BK) and DesArg9BK (DBK). Our aim was to determine the potential expression of k
Brazilian Journal of Medical and Biological Research. Publicado em: 14/03/2007
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9. Estratégias para prospecção e predição de peptídeos bioativos
Chapters one and two deal with the isolation and identification of bioactive peptides from the skin secretion of Phyllomedusa hypochondrialis. The first chapter demonstrates the use of protemic techniques, mainly mass spectrometry, for the study of bradykinin related peptides (BRPs) present in the amphibians secretion and freshly dissected skin fragments. Ei
Publicado em: 2007
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10. Caracterização farmacologica do relaxamento da musculatura lisa do corpo cavernoso humano isolado induzido por cininas
Objective: To caracterize the kinin receptor subtype involved in the relaxation of human isolated corpus cavernosum (HCC) induced by bradykinin (BK). Lysbradykinin (Lys-BK), Met-Lys-bradykinin (Met-Lys-BK) and des-Arg9-bradykinin (des-Arg9-BK), and to investigate whether the kinin-induced relaxation of HCC results from the stimulation of nonadrenergic, nonch
Publicado em: 2002
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11. Scorpion (Buthus tamulus) venom toxicity on cardiopulmonary reflexes involves kinins via 5-HT3 receptor subtypes
The mechanisms underlying the action of Indian red scorpion Buthus tamulus (BT) venom-induced augmentation of cardiopulmonary reflexes elicited by intravenous injection of 5-HT were examined in urethane anaesthetized rats. The 5-HT produced a concentration-dependent increase in time-response area of bradycardiac response, with the responses at submaximal con
Journal of Venomous Animals and Toxins. Publicado em: 2001
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12. Evidence for renal kinins as mediators of amino acid-induced hyperperfusion and hyperfiltration in the rat.
This study examined the role of tissue kallikrein and kinins in renal vasodilation produced by infusion of amino acids (AA). In rats fed a 9% protein diet for 2 wk, intravenous infusion of a 10% AA solution over 60-90 min reduced total renal vascular resistance and increased glomerular filtration rate (GFR) by 25-40% and renal plasma flow (RPF) by 23-30% fro