Efeito anti-inflamatório do óleo essencial de Croton zehntneri pax et hofmm e do Anetol. / Anti-inflammatory effect of essential oil of Croton et pax zehntneri hofmm and Anethole.
AUTOR(ES)
Edson Lopes da Ponte
FONTE
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia
DATA DE PUBLICAÇÃO
15/06/2009
RESUMO
Essential oils from the gender Croton (Euphorbiaceae) are sources of bioactive molecules, from which are obtained several compounds of diverse chemical groups and great therapeutic potential in folk medicine. The essential oil of Croton zehntneri (EOCz), popularly known as Canela-de-Cunhã, possesses anethole, estragole and eugenol as the main constituents. Based on the in vitro antiinflammatory, antioxidant and antinociceptive properties of EOCz and/or its main constituents, the aim of this study was to investigate the underlined mechanism involved in the EOCz and anethole antiinflammatory action, using models of mice paw edema of non immune and immune origin, induced by carrageenin and ovalbumin (in desensitized animals), respectively. The animals subchronic treatment with EOCz and anethole was also performed in order to evaluate possible systemic toxicity. EOCz (10, 30, 100 mg/kg; p.o.) and anethole (3, 10, 30 mg/kg; p.o.) inhibited the paw edema induced by carrageenin about 40 and 31%, respectively. The investigation of the antiinflammatory mechanism showed that EOCz (10mg/Kg) inhibited the edema induced by bradykinin (57%), histamine (54%), sodium nitroprusside (45%) and substance P (33%), but did not alter those induced by serotonin, compound 48/80, arachidonic acid or prostaglandin E2. Anethole inhibited the edema induced by bradykinin (59%), serotonin (45%), substance P (36%) and histamine (30%) but did not interfere with the edema induced by sodium nitroprusside. The EOCz antiedematogenic effect (35%) was also observed in a model of immune inflammation. In summary, the present results show that EOCz and anethole present antiedematogenic activity in a model of acute inflammation, whose mechanism involves mainly their inhibitory action towards kinins, but also upon the late phase mediator nitric oxide. EOCz and anethole do not present systemic toxicity, being this important feature useful for future phytotherapic application.
ASSUNTO(S)
óleo essencial anetol croton zehntneri fisiologia essential oil anethole croton zehntneri
ACESSO AO ARTIGO
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