In Vivo Monitoring
Mostrando 13-24 de 230 artigos, teses e dissertações.
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13. Protein decorated Nanoparticules : Small Unilamellar Lipid Vesicules and Block Copolymers Micelles. / Nanoparticules Décorées par des Protéines : Vésicules Lipidiques Unilamellaires et Micelies à Base de Copolymères à Blocs
The formation of protein Annexin-A5 decorated (bio-functionalized) nanoparticles is of particular interest in micelle-mediated target drug delivery, in vivo magnetic resonance imaging, or controlled fabrication of biochips. This work describes an easy access to the synthesis and manipulation of block copolymer nano-objects exhibiting binding ability for the
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/07/2008
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14. Adducts of 2-desoxiadenosine and 2-desoxicitydine induced of tetrahydrofuran: structural characterization and detection in DNA / Adutos de 2-desoxiadenosina e 2-desoxicitidina induzidos por tetraidrofurano: caracterização estrutural e detecção em DNA
There is a huge concern to identify compounds involved in the development of harmful processes, like cancer. Tetrahydrofuran (THF) is a solvent widely used in industries and recent researches and studies indicated a carcinogenic activity in experimental animals, instigating the investigation of its possible interaction with biomolecules. DNA adducts are used
Publicado em: 2007
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15. Photonic real-time monitoring of bacterial reduction in root canals by genetically engineered bacteria after chemomechanical endodontic therapy
Infecções microbianas são um dos fatores principais no desenvolvimento de necrose pulpar e lesões periapicais. Tradicionalmente, estudos in vivo e in vitro utilizam cultura microbiológica com coletas com cones de papel e quantificação de unidades formadoras de colônia. A maior desvantagem deste método é a dificuldade de se remover as bactérias dos
Brazilian Dental Journal. Publicado em: 2007
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16. Metho of quantification of nucleotides by HPLC-MS/MS and evaluation of the activity of sildenafil analoges in phosphodiesterase / Metodo de quantificação de nucleotideos por HPLC-MS/MS e avaliação da atividade de analogos de sildenafil sobre fosfodiesterase
In the present work a new method for the dosage of the activity of phosphodiesterase was standardized in vitro, for HPLC-MS/MS. This new method obtained to present exactness, precision, sensitivity, and rapidity in the analyses; monitoring the nucleotides (AMP, GMP, cAMP and cGMP). The development of new drug derived from an archetype points with respect to
Publicado em: 2007
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17. Impacto genotÃxico de poluentes quÃmicos presentes na Ãgua e sedimento do Rio Japaratuba (Sergipe)
In situ investigations of the effects of mutagenic pollutants (environmental monitoring) have increasingly used bioindicators, and fish often have been used in these studies as sentinel organisms. In the present study, we have used the piscine micronucleus test (MNT) as an in situ biological indicator of chemical contamination in two fresh water fish species
Publicado em: 2006
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18. AvaliaÃÃo da atividade esquistossomicida do 3 - (4-clorobenzil)-5-(4-nitrobenzilideno)-imidazolidina-2,4-diona (FZ-4) e do Praziquantel frente a Schistosoma mansoni (cepa BH)
Failures, faced in schitossomiasis treatment with prazinquantel, are signing to the necessity to search new drugs to the treatment of this disease as well as monitoring its activity against strains of Schistosoma. The objective of the present work is to evaluate the schistossomicide activity in vivo of the Prazinquantel (PZQ) and the imidazolidine derived 3-
Publicado em: 2006
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19. Metalloporhyrins as Biomimetical MOdels of Cytochrome P450 in the Oxidation of Pesticides / Metaloporfirinas como modelos biomiméticos do citocromo P450 na oxidação de pesticidas"
In this work we investigated the ability of metalloporphyrin model systems to mimic the action of cytochrome P450 in the oxidation of a herbicide, atrazine. To this end, we employed the second generation commercially available metalloporphyrins metal (III) 5,10,15,20-tetrakis(2,6-dichlorophenyl)porphyrin chloride [M(TDCPP)Cl] and metal (III) 5,10,15,20- tetr
Publicado em: 2006
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20. Composição e atividade antifúngica do óleo essencial de hortelã-pimenta (Mentha piperita L.) / Composition and antifungal activity of pepper mint (Mentha piperita L.) essential oil
Pepper mint (Mentha piperita L.) essential oil (EO), obtained by hydro distillation of dry leaves, was evaluated in vitro through a poison food assay (0.1; 0.2 and 0.3%) presented antifungal activity against Aspergillus flavus, A. ochraceous, A. niger, A. glaucus, Fusarium oxysporum, F. semitectum, Colletotrichum musae and C. gloeosporioides. The EO was frac
Publicado em: 2006
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21. Study of the toxicity induced by the anti-inflammatory sulindac and its metabolites, sulindac sulfone and sulindac sulfide / Estudo da toxicidade induzida pelo antiinflamatório sulindaco e seus metabólitos sulfona e sulfeto
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) known to inhibit non-selectively ciclooxygenases (COX) 1 and 2. Sulindac is therapeutically used as anti-inflammatory and analgesic in the symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, and ankylosing spondylits. In addition to this property, a role in the prevention/
Publicado em: 2006
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22. In vitro and in vivo appraisal of pre-heated resin composite with relation to polymerization kinetics / "Avaliação in vitro e in vivo da resina composta pré-aquecida em relação à cinética de polimerização
This work examined multiple aspects of pre-heating dental resin composite prior to light-curing: the monomer conversion and polymerization kinetics as a function of cure temperature, light-exposure duration and depth; the performance of the heating device (maximum temperature, thermal stability of device and temperature change when pre-heating compules); and
Publicado em: 2005
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23. Validation of an ovarian biopsy method for monitoring oocyte development in the fat snook, Centropomus parallelus Poey, 1860 in captivity
A validação de um método de biópsia ovariana para determinação in vivo da maturação ovocitária em Centropomus parallelus foi descrita. Os diâmetros de ovócitos, obtidos de amostras intra-ovarianas sifonadas por cânula, foram analisados a fresco e preservados com formalina (1%) em solução de NaCl (0,7%). Ovócitos em diferentes estádios de matu
Brazilian Archives of Biology and Technology. Publicado em: 2004-08
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24. Mutagenicity of hydroxyurea in lymphocytes from patients with sickle cell disease
Hydroxyurea is commonly used in the treatment of myeloproliferative diseases and in patients with sickle cell disease (SCD). The use of this antineoplastic agent in patients with SCD is justified because of the drug's ability to increase fetal hemoglobin levels, thereby decreasing the severity of SCD. However, high doses or prolonged treatment with hydroxyur
Genetics and Molecular Biology. Publicado em: 2004