Grb
Mostrando 13-24 de 285 artigos, teses e dissertações.
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13. Identificação das glicoproteínas da geléia real de Apis mellifera L. por análise em MALDI-TOF MS
A geléia real (GR), uma secreção produzida pelas glândulas hipofaringeal e mandibular das abelhas operárias, possui uma variedade de atividades farmacológicas, além de ser fundamental para a diferenciação das castas e longevidade da rainha de Apis mellifera. Com o objetivo de identificar alguns dos componentes bioativos deste produto da colméia, ut
Publicado em: 2007
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14. Welding Residual Stress Evaluation of Small Size Pipes Used in Petroleum Refinering / AVALIAÃÃO DAS TENSÃES RESIDUAIS DE SOLDAGEM EM TUBULAÃÃES DE PEQUENO DIÃMETRO USADAS EM REFINARIA DE PETRÃLEO
The aim of this work was to evaluate the behavior of welding residual stress in small size pipes of ASTM A106 Gr. B steel, welded by manual and automatic GTAW processes. It was also evaluated the effect of the welding heat input on residual stress profile, as well as to correlate the results with microstructure and hardness. The residual stress measurement w
Publicado em: 2007
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15. Regulação da transmissão do sinal insulinico em pele intacta e em cicatrização de ratos controles e diabeticos
Insulin is an important regulator of growth and initiates its action by binding to its receptor that undergoes tyrosyl autophosphorylation and further enhances its tyrosine kinase activity towards other intermediate molecules, including insulin receptor substrate-1 (IRS-l), IRS-2 and Shc. IRSs proteins can dock various SH2-containing signaling proteins, such
Publicado em: 2002
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16. Sinalização celular durante aumento de tensão no coração : implicações no desenvolvimento de hipertrofia cardiaca : estudos em corações isolados
The mechanical input plays a major role in cardiac adaptive responses to hemodynamic overload. In addition of triggering the force-Iength mechanism and the homeometric autoregulation, the mechanical input activates signaling mechanisms involved on hypertrophic growth of cardiac myocytes, the hal1mark of themyocardial structural adaptation in response to sust
Publicado em: 2002
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17. Manipulação tubular de sodio e modificações em algumas vias intracelulares relacionadas ao crescimento renal, induzido pela acidose metabolica cronica
A acidose metabólica crônica induzida por cloreto de amônia tem sido relacionada como fator de crescimento renal. No presente estudo, investigou-se a manipulação tubular renal de sódio e alguns passos de vias ligadas ao crescimento celular e expressão gênica em tecido renal de ratos, após a indução de acidose metabólica através da administraçã
Publicado em: 2001
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18. Angiotensin II-mediated vascular smooth muscle cell growth signaling
The mechanism by which Ang II stimulates the growth of vascular smooth muscle cells was investigated by measuring the phosphorylation of mitogen-activated protein kinases ERK 1 and ERK 2. Ca2+ ionophore was found to have effects practically analogous to Ang II. We found that the signaling pathway involves the activation of epidermal growth factor receptor (E
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-06
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19. Sinalização da insulina em sistema nervoso central de ratos
A insulina, agindo através do seu receptor (IR) pertencente à família dos receptores com atividade tiro sina quinase, desencadeia uma série de respostas tecido-específicas mediadas por diferentes vias intracelulares. Uma destas vias, com atividade predominantemente ligada a crescimento celular e mitogênese envolve as proteínas SHC e GRB2. No presente
Publicado em: 2000
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20. Novos substratos do receptor de insulina : regulação da proteina SHC em modelos animais de resistencia a insulina e do IRS-3 em celulas beta pancreaticas
A insulina inicia seus efeitos metabólicos e promotores de crescimento através da ligação à subunidade a do seu receptor. Esta ligação promove a fosforilação em tirosina da subunidade _, e dá inicio a uma cascada de eventos intracelulares, mediante a fosforilação de vários substratos endógenos. Entre os primeiros substratos ativados estão o su
Publicado em: 2000
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21. The Adapter Protein ZIP Binds Grb14 and Regulates Its Inhibitory Action on Insulin Signaling by Recruiting Protein Kinase Cζ
Grb14 is a member of the Grb7 family of adapters and acts as a negative regulator of insulin-mediated signaling. Here we found that the protein kinase Cζ (PKCζ) interacting protein, ZIP, interacted with Grb14. Coimmunoprecipitation experiments demonstrated that ZIP bound to both Grb14 and PKCζ, thereby acting as a link in the assembly of a PKCζ-ZIP-Grb14
American Society for Microbiology.
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22. A novel variant of human Grb7 is associated with invasive esophageal carcinoma.
The cDNAs of a putative growth factor-bound (Grb) 7 signal transduction molecule and Grb7V novel splice variant were isolated from an invasive human esophageal carcinoma. Although both Grb7 isoforms share homology with the Mig-10 cell migration gene, the Grb7V isoform lacks 88 base pairs in the C terminus; the resultant frame shift leads to substitution of a
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23. Molecular cloning of the mouse grb2 gene: differential interaction of the Grb2 adaptor protein with epidermal growth factor and nerve growth factor receptors.
We report the isolation and molecular characterization of the mouse grb2 gene. The product of this gene, the Grb2 protein, is highly related to the Caenorhabditis elegans sem-5 gene product and the human GRB2 protein and displays the same SH3-SH2-SH3 structural motifs. In situ hybridization studies revealed that the mouse grb2 gene is widely expressed throug
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24. Growth Factor Receptor Binding Protein 2-mediated Recruitment of the RING Domain of Cbl to the Epidermal Growth Factor Receptor Is Essential and Sufficient to Support Receptor EndocytosisV⃞
Knockdown of growth factor receptor binding protein 2 (Grb2) by RNA interference strongly inhibits clathrin-mediated endocytosis of the epidermal growth factor receptor (EGFR). To gain insights into the function of Grb2 in EGFR endocytosis, we have generated cell lines in which endogenous Grb2 was replaced by yellow fluorescent protein (YFP)-tagged Grb2 expr
The American Society for Cell Biology.