Glycosaminoglycan
Mostrando 25-36 de 281 artigos, teses e dissertações.
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25. Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-s
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-08
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26. Distribution of versican and hyaluronan in the mouse uterus during decidualization
Preparation for embryo implantation requires extensive adaptation of the uterine microenvironment. This process consists of cell proliferation and cell differentiation resulting in the transformation of endometrial fibroblasts into a new type of cell called decidual cell. In the present study, we followed the space-time distribution of versican and hyalurona
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-08
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27. Collagens and proteoglycans of the corneal extracellular matrix
The cornea is a curved and transparent structure that provides the initial focusing of a light image into the eye. It consists of a central stroma that constitutes 90% of the corneal depth, covered anteriorly with epithelium and posteriorly with endothelium. Its transparency is the result of the regular spacing of collagen fibers with remarkably uniform diam
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-08
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28. ViabilizaÃÃo da heparina como suporte para carrear gentamicina
Many polymers used as drug carriers in controlled delivery systems are polysaccharides. This work propose the use of glycosaminoglycan heparin as carrier for the aminoglycosidic antibiotic gentamicin. Due to their chemical feature, these compounds possess an intrinsic ionic affinity, nevertheless, a carbodiimide was used to promote covalent binding (amide bo
Publicado em: 2002
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29. Galactosaminoglycans from normal myometrium and leiomyoma
In many tumors, the amount of chondroitin sulfate in the extracellular matrix has been shown to be elevated when compared to the corresponding normal tissue. Nevertheless, the degree of chondroitin sulfate increase varies widely. In order to investigate a possible correlation between the amount of chondroitin sulfate and tumor size, several individual specim
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-05
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30. Effect of epithelial debridement on human cornea proteoglycans
Corneal transparency is attributed to the regular spacing and diameter of collagen fibrils, and proteoglycans may play a role in fibrillogenesis and matrix assembly. Corneal scar tissue is opaque and this opacity is explained by decreased ultrastructural order that may be related to proteoglycan composition. Thus, the objectives of the present study were to
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-03
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31. Processos adaptativos do tecido muscular esqueletico e tecido conjuntivo : repercussões sobre a flexibilidade
This study has as its objective to discuss the control mechanisms of structural adaptations in the connective and muscular tissues under different functional conditions. It consists in the development of the interpretations about the plasticity of the tissues related to physical activities in order to improve the motor system s flexibility. Therefore, this b
Publicado em: 1997
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32. Synergism between muramyl dipeptide and lipopolysaccharide in the inhibition of glycosaminoglycan synthesis in cultured rat costal chondrocytes.
The effect of synthetic muramyl dipeptide on glycosaminoglycan synthesis in cultured rat costal chondrocytes was examined. Muramyl dipeptide alone had no effect on the glycosaminoglycan synthesis of rat chondrocytes, whereas Escherichia coli lipopolysaccharide and interleukin 1 alpha inhibited glycosaminoglycan synthesis in a dose dependent manner. Muramyl d
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33. Antibacterial activity of bladder surface mucin duplicated in the rabbit bladder by exogenous glycosaminoglycan (sodium pentosanpolysulfate).
Previous data from our laboratory suggest that the transitional epithelium of the urinary bladder secretes and binds to its surface a glycosaminoglycan. The presence of this substance at the bladder surface markedly reduces the ability of microorganisms to adhere to the mucosa. Furthermore, this glycosaminoglycan can be removed (with acid) and replaced by in
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34. Effect of anti-inflammatory drugs on sulphated glycosaminoglycan synthesis in aged human articular cartilage.
The anti-inflammatory drugs, sodium salicylate, indomethacin, hydrocortisone, ibuprofen, and flurbiprofen, were examined for their effects on sulphated glycosaminoglycan synthesis in aged human cartilage in vitro. Cartilage was obtained from femoral heads removed during surgery and drug effects were found to vary significantly from one head to another. Stati
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35. Sulphated glycosaminoglycan synthesis in normal and osteoarthrotic hip cartilage.
The in vitro sulphated glycosaminoglycan metabolism and uronate content of human aged and osteoarthrotic hip articular cartilages have been examined. Cartilages were sampled from nonfibrillated weight-bearing areas and cultured in Dulbecco Modified Eagle's medium with 35SO4. Uptake of 35SO4 was corrected for total sulphate concentration and related to uronat
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36. Identification of the glycosaminoglycan-attachment site of mouse invariant-chain proteoglycan core protein by site-directed mutagenesis.
The invariant chain (Ii), a nonpolymorphic glycoprotein that associates with the immunoregulatory Ia proteins encoded by the major histocompatibility complex, has a proteoglycan form (Ii-CS) that bears a chondroitin sulfate glycosaminoglycan. In this proteoglycan form, Ii may remain associated with Ia at the cell surface. Inhibitors that prevent the addition