Importance of hyaluronan biosynthesis and degradation in cell differentiation and tumor formation
AUTOR(ES)
Heldin, P.
FONTE
Brazilian Journal of Medical and Biological Research
DATA DE PUBLICAÇÃO
2003-08
RESUMO
Hyaluronan is an important connective tissue glycosaminoglycan. Elevated hyaluronan biosynthesis is a common feature during tissue remodeling under both physiological and pathological conditions. Through its interactions with hyaladherins, hyaluronan affects several cellular functions such as cell migration and differentiation. The activities of hyaluronan-synthesizing and -degrading enzymes have been shown to be regulated in response to growth factors. During tumor progression hyaluronan stimulates tumor cell growth and invasiveness. Thus, elucidation of the molecular mechanisms which regulate the activities of hyaluronan-synthesizing and -degrading enzymes during tumor progression is highly desired.
Documentos Relacionados
- Regulated protein degradation controls PKA function and cell-type differentiation in Dictyostelium
- Modulation of TGFβ1-Dependent Myofibroblast Differentiation by Hyaluronan
- Structural basis of hyaluronan degradation by Streptococcus pneumoniae hyaluronate lyase
- Glutamine as a regulator of DNA and protein biosynthesis in human solid tumor cell lines.
- Intratumoral Delivery of Paclitaxel in Solid Tumor from Biodegradable Hyaluronan Nanoparticle Formulations