Genes Drug Effects
Mostrando 1-12 de 113 artigos, teses e dissertações.
-
1. Antimony resistance in Leishmania (Viannia) braziliensis clinical isolates from atypical lesions associates with increased ARM56/ARM58 transcripts and reduced drug uptake
BACKGROUND In addition to the limited therapeutic arsenal and the side effects of antileishmanial agents, drug resistance hinders disease control. In Brazil, Leishmania braziliensis causes atypical (AT) tegumentary leishmaniasis lesions, frequently refractory to treatment. OBJECTIVES The main goal of this study was to characterise antimony (Sb)-resistant
Mem. Inst. Oswaldo Cruz. Publicado em: 15/08/2019
-
2. Comparing the effects of vitamin E tocotrienol-rich fraction supplementation and α-tocopherol supplementation on gene expression in healthy older adults
OBJECTIVES This study aims to compare the differential gene expression resulting from tocotrienol-rich fraction and α-tocopherol supplementation in healthy older adults. METHODS A total of 71 eligible subjects aged 50 to 55 years from Gombak and Kuala Lumpur, Malaysia, were divided into three groups and supplemented with placebo (n=23), α-tocopherol (n
Clinics. Publicado em: 11/03/2019
-
3. Natural products as new antimitotic compounds for anticancer drug development
Cell cycle control genes are frequently mutated in cancer cells, which usually display higher rates of proliferation than normal cells. Dysregulated mitosis leads to genomic instability, which contributes to tumor progression and aggressiveness. Many drugs that disrupt mitosis have been studied because they induce cell cycle arrest and tumor cell death. Thes
Clinics. Publicado em: 10/12/2018
-
4. Cellular and molecular studies of the effects of a selective COX-2 inhibitor celecoxib in the cardiac cell line H9c2 and their correlation with death mechanisms
Cardiovascular disease is one of the leading causes of death worldwide, and evidence indicates a correlation between the inflammatory process and cardiac dysfunction. Selective inhibitors of cyclooxygenase-2 (COX-2) enzyme are not recommended for long-term use because of potentially severe side effects to the heart. Considering this and the frequent prescrib
Braz J Med Biol Res. Publicado em: 29/11/2013
-
5. Influence of the dopaminergic system, CREB, and transcription factor-κB on cocaine neurotoxicity
Cocaine is a widely used drug and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newborns have been demonstrated to be due to the toxic effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damage is complex and involves interactions of the drug with several neurotransmitter
Braz J Med Biol Res. Publicado em: 15/10/2013
-
6. Pharmacogenetics in schizophrenia: a review of clozapine studies
Objectives: Clozapine is quite effective to treat schizophrenia, but its use is complicated by several factors. Although many patients respond to antipsychotic therapy, about 50% of them exhibit inadequate response, and ineffective medication trials may entail weeks of unremitted illness, potential adverse drug reactions, and treatment nonadherence. This re
Rev. Bras. Psiquiatr.. Publicado em: 2013-09
-
7. Avaliação dos Efeitos Antineoplásicos da Zebularina em Linhagens Pediátricas de Leucemia Linfoide Aguda. / Evaluation of Antineoplastic Effects of Zebularine on Childhood Acute Lymphoblastic Leukemia Cell Lines.
A leucemia linfóide aguda (LLA) é a neoplasia hematológica mais comum na infância e representa uma doença heterogênea em relação à biologia e ao prognóstico e seu tratamento consiste principalmente em quimioterapia. Apesar dos avanços no tratamento, cerca de 20% dos pacientes apresentam recaída da doença e/ou óbito indicando a necessidade de te
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/03/2012
-
8. Influência dos polimofismos de nucleotídeo único (SNPs) da APOBEC3G na dinâmica populacional da infecção pelo HIV-1 / Influence of single nucleotide polymorphisms of APOBEC3G in the population dynamic in the HIV-1 infection
APOBEC3G (A3G) has been described as a cellular factor that inhibits replication of HIV-1. During reverse transcription, A3G promotes deamination of cytidine to uracil in the minus strand viral DNA, inducing hypermutation of guanines to adenines in plus strand DNA. The HIV-1 counters this effect by the activity of the viral protein Vif, which counteracts A3G
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 28/04/2011
-
9. Cytogenetic effect of 5-azacytidine in patients with hematological malignancies
BACKGROUND: Recently, the importance of cytogenetics has grown in the diagnosis, prognosis and treatment of leukemias and myelodysplastic syndromes. 5-azacytidine is a drug that has well-known cytogenetical effects and is approved in the treatment of myelodysplastic syndromes. To date, no studies have been performed to evaluate the impact of 5-azacytidine on
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2011-10
-
10. Influência da variabilidade genética humana dos genes NAT2, CYP2E1, GSTM1 e GSTT1 na ocorrência de reações adversas hepáticas induzidas pela isoniazida em pacientes com tuberculose ativa / Influence of human genetic variability of genes NAT2, CYP2E1, GSTM1 and GSTT1 in the occurrence of hepatic adverse reactions induced by isoniazid in patients with active tuberculosis
A isoniazida (INH), uma das principais drogas usadas no esquema de tratamento de primeira linha anti-tuberculose (anti-TB), tem sido associada à intensificação de efeitos adversos principalmente hepáticos. Sabe-se hoje, que variações polimórficas em genes humanos codificando enzimas envolvidas na biotransformação de diferentes fármacos podem contri
Publicado em: 2009
-
11. Klebsiella pneumoniae: estudo molecular dos fatores de resistÃncia e caracterizaÃÃo ultra-estrutural da aÃÃo de antibiÃticos β-lactÃmicos
Klebsiella pneumoniae is an enterobacteria responsible for a high incidence of hospital infections usually caused by strains carrier of multidrug resistance and producer of broad spectrum -lactamase (ESBL). This study aimed to determine the genes involved in the formation of classical beta-lactamases and ESBLs in Recife-PE, Brazil, and investigate th
Publicado em: 2009
-
12. Toxicidade causada pela cocaína in vitro: participação da via dopaminérgica e do fator de transcrição NF-kB. / In vitro cocaine toxicity: participation of the dopaminergic pathway and the transcription factor NF-kB.
Cocaine is a drug deeply used and its abuse is associated with physical, psychiatric and social problems. Abnormalities in newly born have been demonstrated due to the toxics effects of cocaine during fetal development. The mechanism by which cocaine causes neurological damages is very complex and involves interactions of the drug with several neurotransmitt
Publicado em: 2008