Field Cancerization
Mostrando 1-9 de 9 artigos, teses e dissertações.
-
1. Efficacy of sunscreen with photolyase or regular sunscreen associated with topical antioxidants in treating advanced photodamage and cutaneous field cancerization: a randomized clinical trial
Abstract Background Several treatments are available for skin with advanced photodamage, which is characterized by the presence of actinic keratoses (AK). Objectives Evaluate the efficacy of using sunscreen with photolyase compared to regular sunscreen, as well as to compare the combination of a topical formulation of antioxidants versus placebo in the tre
Anais Brasileiros de Dermatologia. Publicado em: 2022
-
2. Growth hormone in the tumor microenvironment
ABSTRACT Tumor development is a multistep process whereby local mechanisms enable somatic mutations during preneoplastic stages. Once a tumor develops, it becomes a complex organ composed of multiple cell types. Interactions between malignant and non-transformed cells and tissues create a tumor microenvironment (TME) comprising epithelial cancer cells, cance
Arch. Endocrinol. Metab.. Publicado em: 10/01/2020
-
3. Treatment of actinic keratoses and cancerization field of the face and scalp with 0.015% ingenol mebutate gel in Brazilian individuals: safety, tolerability and patients' perspectives
Abstract: Background: Actinic keratosis (AK) represents a risk of progression to squamous cell carcinoma. Ingenol mebutate gel is a novel therapeutic option for field-directed treatment. Objectives: To evaluate the safety, tolerability and patients' perspectives, related to the therapeutic success of managing AKs on the face and scalp with ingenol mebutate
An. Bras. Dermatol.. Publicado em: 29/07/2019
-
4. Ingenol mebutate in the treatment of actinic keratoses: clearance rate and adverse effects
Abstract: Background: Actinic keratoses are benign intraepithelial skin neoplasms that develop in photoexposed areas and can progress to invasive carcinoma. They are seen frequently in dermatological practice, occurring in 5.1% of consultations. Ingenol mebutate (IM) was recently approved in Brazil as a topical therapy for field cancerization in actinic ker
An. Bras. Dermatol.. Publicado em: 2018-08
-
5. Estudo da pele do campo cancerizável antes e após a terapia fotodinâmica através dos métodos clínicos, histopatológicos e imunohistoquímicos / Clinical, histopathological and immunohistochemical assessment of human skin field cancerization before and after photodynamic therapy
O conceito de campo de cancerização, em dermatologia, sugere que a pele fotodanificada tem maior potencial para o desenvolvimento de neoplasias cutâneas. A terapia fotodinâmica (TFD) é um método não invasivo para o tratamento de queratoses actínicas (QA) múltiplas, possibilitando a abordagem de todo o campo. Vinte e seis pacientes com múltiplas QAs
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/11/2011
-
6. Evaluation of ethanol consumption, tobacco smoking and dietary habits as predictive factors for the development of esophageal cancer in patients with primary tumors in the head and neck / Avaliação do consumo de etanol e tabaco e dos hábitos alimentares como fatores preditivos para o desenvolvimento de câncer de esôfago em pacientes portadores de neoplasia primária de cabeça e pescoço
O carcinoma espinocelular é o principal tipo histológico de neoplasia esofágica, com o pico de incidência ocorrendo na 6ª década de vida, o que sugere a ação prolongada de agente(s) carcinogênico(s) do ambiente externo como fator etiológico. A associação entre câncer de cabeça e pescoço e esôfago é conhecida de longa data, ocorrendo em 2 a 3
Publicado em: 2007
-
7. Estudo de marcadores p53 e Ki-67 na cancerização de campo na mucosa não tumoral adjacente a tumores de cavidade oral.
Os carcinomas epidermóides são responsáveis por mais de 90% dos tumores malignos da cavidade oral. O prognóstico pode ser muito ruim quando ocorrem segundos tumores primários nessas áreas, que estão mais predispostas ao desenvolvimento de lesões potencialmente malignas. Essa predisposição é reconhecida como fenômeno de cancerização de campo, po
Publicado em: 2007
-
8. Expressão precoce de CD34, CD68, α-actina de músculo liso e COX-2 no estroma pericriptal durante carcinogênese colônica induzida quimicamente em ratos. / Early Expression of CD34, CD68, α-smooth muscle actin and COX-2 in pery-crypt stroma during chemically-induced rat colonic carcinogenesis.
There has been considerable that the activity of epithelial cells with their stroma is fundamental in controlling growth and differentiation in normal and pathological situations, including cancer. A number of reports stress the importance of the stromal compartment in malignant tumors and strongly indicate that continuous interactions between the carcinoma
Publicado em: 2006
-
9. Constitutive activation of Stat3 signaling abrogates apoptosis in squamous cell carcinogenesis in vivo
Field cancerization predisposes the upper aerodigestive tract mucosa to the formation of multiple primary tumors, when exposed to environmental carcinogens. Up-regulation of epidermal growth factor receptor occurs early in squamous cell carcinogenesis and is critical for the loss of growth control in a variety of human cancers, including head and neck s
The National Academy of Sciences.