Expressão precoce de CD34, CD68, α-actina de músculo liso e COX-2 no estroma pericriptal durante carcinogênese colônica induzida quimicamente em ratos. / Early Expression of CD34, CD68, α-smooth muscle actin and COX-2 in pery-crypt stroma during chemically-induced rat colonic carcinogenesis.

AUTOR(ES)
DATA DE PUBLICAÇÃO

2006

RESUMO

There has been considerable that the activity of epithelial cells with their stroma is fundamental in controlling growth and differentiation in normal and pathological situations, including cancer. A number of reports stress the importance of the stromal compartment in malignant tumors and strongly indicate that continuous interactions between the carcinoma and stromal cells (resulting in their reciprocal regulation and modulation) are prerequisites for carcinoma development and progression. Comparatively, less information is available about the features and role of the stroma for the carcinogenic process. In animals treated with the carcinogen Dimethyl-hydrazine we identified the appearing of mucosal “Activated Stromal Foci” (ASF) that differ from the sporadic inflammatory foci found in the normal mucosa of the control animals because of the presence of increased immune-expression of CD34, CD68, α-smooth muscle actin (ASMA), COX-2 positive cells and microvessel density. Furthermore, the ASF surrounded a increased number of colonic crypts in fission when compared to areas of normal stroma. This last finding suggests that stromal activation and epithelial changes may be correlated. These findings are novel but expected and consistent with previous observations that the stroma has a significant role in carcinogenesis. Taken together with literature data, our findings suggest that in the colon, the epithelial field cancerization may be accompanied by stromal changes and this may point to the finding of new markers of neoplastic transformation.

ASSUNTO(S)

alfa-actina de músculo liso cd34 2 – dimetilhidrazina (dmh) α 1 colonic carcinogenesis 2-dimethylhydrazine dihydrochloride (dmh) cd68 cd68 cox-2 estroma pericriptal carcinogênese colônica cox-2 -smooth muscle actin (asma) cd34 1 pery-crypt stroma

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