Endocytosis
Mostrando 1-12 de 1236 artigos, teses e dissertações.
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1. [PROVISIONAL] The combined risk effect among BIN1, CLU and APOE genes in Alzheimer’s disease
Abstract Genome-wide associations studies (GWAS) have been detecting new variants associated with late-onset of Alzheimer’s disease (LOAD), a multifactorial neurodegenerative disorder. The variants rs744373 BIN1, rs11136000 CLU rs3764650 ABCA7 uncovered by GWAS led to different AD pathways, such as metabolism, trafficking and endocytosis of lipids and infl
Genet. Mol. Biol.. Publicado em: 29/08/2019
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2. Increased expression levels of Syntaxin 1A and Synaptobrevin 2/Vesicle-Associated Membrane Protein-2 are associated with the progression of bladder cancer
Abstract Gene expression is tightly regulated in time and space through a multitude of factors consisting of signaling molecules. Soluble N-ethylmaleimide-sensitive-factor attachment protein receptors (SNARE) are membrane proteins responsible for the intercellular trafficking of signals through endocytosis and exocytosis of vesicles. Altered expression of SN
Genet. Mol. Biol.. Publicado em: 21/01/2019
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3. Decreased serum PON1 arylesterase activity in familial hypercholesterolemia patients with a mutated LDLR gene
Abstract Paraoxonase 1 (PON1) is a serum enzyme associated with high density lipoprotein (HDL) regulation through its paraoxonase and arylesterase activity. PON1 inhibits the oxidation of HDL and low density lipoprotein (LDL), and is involved in the pathogenesis of a variety of diseases including atherosclerosis. Conversely, mutations in the low density lipo
Genet. Mol. Biol.. Publicado em: 23/07/2018
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4. COMO ESTUDAR INTERAÇÕES ENTRE NANOPARTÍCULAS E SISTEMAS BIOLÓGICOS
Although in recent years there has been an increasing amount of literature on nanotechnology and their clinical applications, it is still scarce a deep understanding of the interactions at the molecular levels between nanoparticles and cells. Studies demonstrating the underlying mechanisms of nanoparticles endocytosis, intracellular trafficking, and cellular
Quím. Nova. Publicado em: 2016-12
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5. The dynamic structure of Spitzenkörpers of Trichosporon asahii examined by the fluorescent probe FM4-64
Abstract The Spitzenkörper is a dynamic and specialized multicomponent cell complex present in the tips of hyphal cells. The amphiphilic styryl dye FM4-64 was found to be ideal for imaging the dynamic changes of the apical vesicle cluster within growing hyphal tips. It is widely used as a marker of endocytosis and to visualize vacuolar membranes. Here we pe
Braz. J. Microbiol.. Publicado em: 2016-03
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6. Bases moleculares da microalbuminúria associada à hipertensão arterial essencial: papel da reabsorção tubular de albumina / Molecular basis of microalbuminuria in essential hypertension: role of tubular albumin reabsorption
Evidências epidemiológicas indicam que a presença de microalbuminúria prediz maior freqüência de eventos cardiovasculares e mortalidade em hipertensos essenciais. A microalbuminúria pode ser decorrente do aumento da permeabilidade glomerular e/ou da diminuição da reabsorção desta macromolécula no túbulo proximal. Todavia não é sabido se os mec
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/10/2012
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7. Peptídeos Potencialmente Úteis no Tratamento do Câncer de Mama e o Envolvimento de Componentes da Matriz Extracelular na Resistência ao Trastuzumab..
HER2 is a member of epidermal growth factor family of receptors that is an essential mediator of cell proliferation and differentiation. In breast cancer patients, HER2 overexpression is associated with disease aggressiveness, chemo and hormone therapy resistance and poor prognosis. Currently, a HER2 specific monoclonal antibody named trastuzumab, was develo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/02/2011
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8. Phyllanthus niruri as a promising alternative treatment for nephrolithiasis
In spite of considerable efforts to identify effective treatments for urolithiasis, this is a goal yet to be achieved. This review summarizes experimental and clinical data evaluating the effect of the plant Phyllanthus niruri, a plant with worldwide distribution, as a potential agent to prevent and/or to treat urolithiasis The review is based on data from t
International braz j urol. Publicado em: 2010-12
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9. Noncrystalline uric acid inhibits proteoglycan and glycosaminoglycan synthesis in distal tubular epithelial cells (MDCK)
Hyperuricemia is associated with renal stones, not only consisting of uric acid (UrAc) but also of calcium oxalate (CaOx). Glycosaminoglycans (GAGs) are well-known inhibitors of growth and aggregation of CaOx crystals. We analyzed the effect of noncrystalline UrAc on GAG synthesis in tubular distal cells. MDCK (Madin-Darby canine kidney) cells were exposed t
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-10
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10. Identificação de proteínas que interagem com a porção citoplasmática C-terminal do receptor para Angiotensina II (AT1aR) em células de tecido renal / Identification of binding-partners interacting with the intracellular c-terminal domain of the angiotensin II receptor AT1aR in rat renal tissue
O receptor para Angiotensina II tipo 1 (AT1R) é expresso tanto em membrana apical quanto basolateral dos túbulos proximais renais. Embora haja evidências de diferenças funcionais entre receptores apicais e basolaterais, como, por exemplo, a dependência do processo de internalização de receptores apicais, mas não de basolaterais, para a efetivação d
Publicado em: 2010
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11. Expressão gênica e protéica do canal de cálcio do tipo L e seu envolvimento com o mecanismo de secreção de insulina em ilhotas de langerhans de ratos submetidos à restrição protéica e suplementados com leucina / Gene and protein expression of L type calcium channel and your involvement in the mechanism of insulin secretion in islets of Langerhans of rats submitted to protein restriction and supplementation with leucine
Voltage-dependent calcium channels (CaV) are plasma membrane proteins that lead calcium, and are activated by depolarization of the same by promoting the influx of this ion, which serves as an intracellular second messenger, turning electrical signals into chemical. This process controls several intracellular events such as exocytosis, endocytosis, muscle co
Publicado em: 2010
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12. Interação do cininogênio humano de alta massa molecular com a superfície celular: envolvimento dos processos de endocitose e proteólise / High molecular weight human kininogen interact with cell surface: Involvement endocytosis and proteolysis process
A angiogênese e a hemostasia estão entre as mais consistentes respostas do hospedeiro associadas ao câncer, e essas duas vias interrelacionam-se, com a coagulação sanguínea e a fibrinólise influenciando a angiogênese tumoral diretamente e contribuindo com o crescimento do tumor. O fato dos tumores serem dependentes do suprimento sanguíneo tem inspir
Publicado em: 2010