Enantiomeric Separation
Mostrando 1-12 de 15 artigos, teses e dissertações.
-
1. Enantiomeric Separation of Sibutramine by Capillary Zone Electrophoresis
The chiral separation of sibutramine enantiomers was resolved succesfully by capillary zone electrophoresis using cyclodextrins (CDs) as chiral selectors. A complex screening of several different native and derivatized, neutral and ionized cyclodextrine derivatives was performed. The effects of buffer type, concentration and pH, cyclodextrin type and concent
J. Braz. Chem. Soc.. Publicado em: 2016-06
-
2. CHROMATOGRAPHIC SEPARATION OF VERAPAMIL RACEMATE USING A VARICOL CONTINUOUS MULTICOLUMN PROCESS
Abstract Verapamil is a chiral drug that is marketed in its racemic form, but because of the pharmacological effects due to molecule’s chirality, one of the enantiomers is more potent, and the other exhibits different activities of therapeutic interest. The preparative separation of the verapamil enantiomers was performed using a continuous Varicol unit op
Braz. J. Chem. Eng.. Publicado em: 2015-12
-
3. Coupling DLLME-CE for the Stereoselective Analysis of Venlafaxine and Its Main Metabolites after Biotransformation by Fungi
Fungal biotransformations have become very important in the study of chiral drugs because the reactions performed by these microorganisms may be enantioselective. However, analyses of analytes present in liquid culture medium have proved to be very difficult due to the complexity of this matrix. The aim of this work was to couple dispersive liquid-liquid mic
J. Braz. Chem. Soc.. Publicado em: 2015-09
-
4. Evaluation of microbiological and biomimetic models in stereoselective metabolism of risperidone by high-performance liquid chromatography / Avaliação de modelos microbiológicos e modelos biomiméticos no metabolismo estereosseletivo da risperidona por cromatografia líquida de alta eficiência
Risperidone is an atypical antipsychotic drug. Its metabolism yields in two hydroxylated chiral metabolites, 7-hydroxyrisperidone (7-RispOH) and 9-hydroxyrisperidone (9-RispOH). The 9-RispOH metabolite presents the same pharmacologic activity of the parent drug risperidone. This led this drug to be marketed as drug under the generic name paliperidone. Studie
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 02/08/2012
-
5. A validated chiral LC method for the enantiomeric separation of repaglinide on immobilized amylose based stationary phase
Um método de HPLC quiral em fase normal, simples, rápido, isocrático, foi desenvolvido e validado para a separação enantiomérica de repaglinida, ácido (S)-(+)-2-etóxi-4-N [1-(2-piperidinofenil)-3-metil-1-butil] aminocarbonilmetil] benzóico, uma substância antidiabética. Os enantiômeros de repaglinida foram resolvidos em uma coluna Chiralpak IA (f
Journal of the Brazilian Chemical Society. Publicado em: 2012-06
-
6. Composição e variabilidade enantiomérica de α-pineno em Constrictotermes cyphergaster (Silvestri, 1901) (Isoptera; Termitidae) / Composition and enantiomeric variability of α-pinene in Constrictotermes Cyphergaster (Silvestri, 1901) (Isoptera; Termitidae)
Termites are eusocial insects of isoptera order that part in seven families. In this study we analyze the chirality of α-pinene in the defensive secretion that C. cyphergaster (Isoptera, Termitidae, Nasutitermitinae) this compound showed that among the majority of termite volatile. Along with checking the chirality was made a study seeking to correlate
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
-
7. Composição e variabilidade enantiomérica de α-pineno em Constrictotermes cyphergaster (Silvestri, 1901) (Isoptera; Termitidae) / Composition and enantiomeric variability of α-pinene in Constrictotermes Cyphergaster (Silvestri, 1901) (Isoptera; Termitidae)
Termites are eusocial insects of isoptera order that part in seven families. In this study we analyze the chirality of α-pinene in the defensive secretion that C. cyphergaster (Isoptera, Termitidae, Nasutitermitinae) this compound showed that among the majority of termite volatile. Along with checking the chirality was made a study seeking to correlate
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 07/10/2011
-
8. Separação enantiomérica do marcador molecular fmoc-poac em fase estacionária normal e reversa / Enantiomeric separation of fmoc-poac spin label by HPLC in normal and reverse stationary phase
A enantiosseparação de alguns compostos é um brilhante e interessante tópico de muitas áreas da química analítica, principalmente na farmacêutica e biomédica. Sabe-se que apesar dos enantiômeros apresentarem fórmulas e massa molecular iguais, quando expostos em um ambiente biológico podem mostrar grandes diferenças nas suas atividades biológica
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 22/09/2011
-
9. Enantiomeric distribution of key volatile components in Citrus essential oils
Citrus as many other plants present characteristic distribution of some enantiomers, thus it is often possible to use this parameter for identification, characterization, genuineness, and pharmacological activity assessment. In particular, it is possible to reveal adulteration of different nature, such as addition of synthetic compounds, or natural component
Revista Brasileira de Farmacognosia. Publicado em: 08/07/2011
-
10. Citalopram : desenvolvimento e validação de métodos analíticos, perfil de dissolução, separação enantiomérica e estudo preliminar de fotoestabilidade para a forma farmacêutica comprimido / Citalopram : development and validation of analytical methods, dissolution profile, enantiomeric separation and preliminary photostability study to the pharmaceutical dosage form
Neste trabalho foram desenvolvidos ensaios para a análise qualitativa do citalopram utilizando espectrofotometria na região do ultravioleta, cromatografia em camada delgada e cromatografia líquida (CL); caracterização da SQR do citalopram por espectrometria na região do infravermelho, espectrofotometria na região do ultravioleta e determinação do po
Publicado em: 2008
-
11. Review- Alternatives for the separation of drug enantiomers: ibuprofen as a model compound
Given the inherent dangers associated with racemic pharmaceuticals, exhaustive studies of techniques designed to separate enantiomers have been conducted. This paper reports a brief review of the different physical, chemical, and enzymatic methods used for the enantiomeric separation of rac-ibuprofen. The possible contribution of each technique to the prepar
Brazilian Journal of Chemical Engineering. Publicado em: 2006-09
-
12. Separação do racemato N-Boc-Rolipram pelo processo cromatografico de leito movel simulado utilizando fase estacionaria quiral tris-(3,5-dimetilfenilcarbamato de celulose) suportada em silica
Chiral stationary phases (CSPs) have shown efficiency in racemate purification. Rolipram, (mais ou menos)-4-(3-(cyclopentyloxy)-4-methoxyphenyl)- pyrrolidin-2-one, is an antidepressant with significant pharmacological properties. The main objective of this work was Rolipram purification in the Chiral Stationary Phase tris(3,5-dimethylphenylcarbamoyl) cellulo
Publicado em: 2005