Enantiomeric Separation
Mostrando 13-15 de 15 artigos, teses e dissertações.
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13. Simulated moving-bed adsorption for separation of racemic mixtures
The two enantiomers that constitute a racemate have different activities when employed as pharmaceuticals. Due to this fact, fully recognized today, the pharmaceutical industry has been forced to market pure enantiomers instead of the racemic mixture whenever a chiral compound is involved. The simulated moving bed (SMB) is a chromatographic process that, unl
Brazilian Journal of Chemical Engineering. Publicado em: 2004-01
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14. Chiral Ligand Exchange Chromatography: Separation of Enantiomeric Mixtures of Underivatized α-Amino Acids under UV Detection
Misturas de enantiômeros de alanina, serina, threonina, valina, metionina, leucina e norleucina foram resolvidas cromatograficamente (e reprodutivelmente), através de cromatografia líquida de alta eficiência (CLAE) com fase reversa, por troca de ligantes, utilizando-se L-prolina, L-hidroxiprolina ou N,N-dimetil-L-fenilalanina (2 mmol L-1) e Cu(CH3COO)2 (
Journal of the Brazilian Chemical Society. Publicado em: 2002-09
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15. Separação enantiomérica de fármacos em medicamentos por cromatografia líquida com fase estacionária quiral / Direct enantiomeric separation of drugs in pharmaceutical by high performance liquid chromatography with chiral stationary phase
The majority of the therapeutic agents, frequently prescribed, are formulated and commercialized as racemic mixture, even so for some of them, it has been demonstrated that the pharmacological and/or toxic effect are confined only to one of the enantiomer. Besides, it is well known that the enantiomers can present different pharmacokinetic and pharmacodynami
Publicado em: 2002