Review- Alternatives for the separation of drug enantiomers: ibuprofen as a model compound

AUTOR(ES)

Carvalho, P. O., Cass, Q. B., Calafatti, S. A., Contesini, F. J., Bizaco, R.

FONTE

Brazilian Journal of Chemical Engineering

DATA DE PUBLICAÇÃO

2006-09

RESUMO

Given the inherent dangers associated with racemic pharmaceuticals, exhaustive studies of techniques designed to separate enantiomers have been conducted. This paper reports a brief review of the different physical, chemical, and enzymatic methods used for the enantiomeric separation of rac-ibuprofen. The possible contribution of each technique to the preparation of enantiomerically pure drugs is reviewed in the context of competitive approaches that depend on the scale of application, with special emphasis on the recent progress achieved in this particular area.

Documentos Relacionados

• Different Degradation Patterns of Chiral Contaminant Enantiomers: Paclobutrazol as a Case Study
• In vitro evaluation of sustained released matrix tablets containing ibuprofen: a model poorly water-soluble drug
• Association of Actinomycin D and Deoxyribodinucleotides as a Model for Binding of the Drug to DNA
• Carbon nanotubes as a novel drug delivery system for anticancer therapy: a review
• Production of S-(+)-ibuprofen from a nitrile compound by Acinetobacter sp. strain AK226.