Doxorubicin
Mostrando 25-36 de 285 artigos, teses e dissertações.
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25. Profile of bioactive compounds of Capparis spinosa var. aegyptiaca growing in Egypt
ABSTRACT The present study was designed to investigate polyphenolic and sulphur contents of the aerial parts of Capparis spinosa var. aegyptia (Lam.) Boiss., Capparaceae, wildly growing in Egypt. The chemical compositions of the water distilled essential oil were investigated by GC/MS analysis where the major constituent of the oil was methyl isothiocyanate
Rev. bras. farmacogn.. Publicado em: 2016-08
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26. Protective effect of Rheum turkestanikum root against doxorubicin-induced toxicity in H9c2 cells
Abstract Doxorubicin is a chemotherapy drug but its clinical using is limited because of its cardiotoxicity. Reactive oxygen species play an important role in the pathological process. The aim of this study is to evaluate the protective effect of Rheum turkestanicum Janisch., Polygonaceae, against doxorubicin-induced apoptosis and death in H9c2 cells. The ce
Rev. bras. farmacogn.. Publicado em: 2016-06
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27. Functionalized Multi Walled Carbon Nanotubes as a Carrier for Doxorubicin: Drug Adsorption Study and Statistical Optimization of Drug Loading by Factorial Design Methodology
Multi walled carbon nanotubes (MWNTs) have been identified as an efficient drug carrier. Here a controlled drug delivery system based on modified MWNTs with polyethylene glycol (PEG) was developed (MWNTs-PEG). Then doxorubicin (DOX) as an anticancer drug loaded to nanocarrier. All the parameters affecting the DOX adsorption such as: dose of adsorbent, pH, in
J. Braz. Chem. Soc.. Publicado em: 2016-04
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28. Cytotoxic activity of phenolic constituents from Echinochloa crus-galli against four human cancer cell lines
Abstract Echinochloa crus-galli (L.) P. Beauv., Poaceae, grains are used as a feed for birds and millet for humans. The sulforhodamine B assay was used to assess its cytotoxicity against four human cancer cell lines. The ethanolic extract (70%) proved to be most active against HCT-116 and HELA cell lines (IC50 = 11.2 ± 0.11 and 12.0 ± 0.11 µg/ml, respecti
Rev. bras. farmacogn.. Publicado em: 2016-02
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29. Primary nodal peripheral T-cell lymphomas: diagnosis and therapeutic considerations
Nodal peripheral T-cell lymphomas are a rare group of neoplasms derived from post-thymic and activated T lymphocytes. A review of scientific articles listed in PubMed, Lilacs, and the Cochrane Library databases was performed using the term "peripheral T-cell lymphomas". According to the World Health Organization classification of hematopoietic tissue tumors,
Rev. Bras. Hematol. Hemoter.. Publicado em: 2015-08
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30. Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin
AbstractPegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palma
An. Bras. Dermatol.. Publicado em: 2015-06
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31. Contractile profile of esophageal and gastric fundus strips in experimental doxorubicin-induced esophageal atresia
Esophageal atresia (EA) is characterized by esophageal and gastric motility changes secondary to developmental and postsurgical damage. This study evaluated the in vitro contractile profile of the distal esophagus and gastric fundus in an experimental model of EA induced by doxorubicin (DOXO). Wistar pregnant rats received DOXO 2.2 mg/kg on the 8th and 9th g
Braz J Med Biol Res. Publicado em: 06/03/2015
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32. Metronomic chemotherapy in the neoadjuvant setting: results of two parallel feasibility trials (TraQme and TAME) in patients with HER2+ and HER2− locally advanced breast cancer
Neoadjuvant chemotherapy has practical and theoretical advantages over adjuvant chemotherapy strategy in breast cancer (BC) management. Moreover, metronomic delivery has a more favorable toxicity profile. The present study examined the feasibility of neoadjuvant metronomic chemotherapy in two cohorts [HER2+ (TraQme) and HER2− (TAME)] of locally advanced BC
Braz J Med Biol Res. Publicado em: 06/03/2015
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33. Recombinogenic activity of Pantoprazole® in somatic cells of Drosophila melanogaster
Pantoprazole® is one of the leading proton pump inhibitors (PPIs) used in the treatment of a variety of diseases related to the upper gastrointestinal tract. However, studies have shown an increased risk of developing gastric cancer, intestinal metaplasia and hyperplasia of endocrine cells with prolonged use. In the present study, the somatic mutation and r
Genet. Mol. Biol.. Publicado em: 2015-03
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34. Bleomycin-induced flagellate dermatitis
A 29-year-old woman with stage IVB Hodgkin's lymphoma was treated with doxorubicin, bleomycin, vinblastine, and dacarbazine. Two weeks after the first cycle was completed, she developed pruritic, linear erythematous lesions in a flagellate-like pattern on the trunk, neck and arms. After oral prednisone therapy and cessation of bleomycin, the lesions started
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-07
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35. Case for diagnosis
We report the case of a 81-year-old female patient who had a two-year history of violet-colored erythematous tumors on both legs. Histopathological and immunohistochemical examinations confirmed the diagnosis of primary cutaneous large B-cell lymphoma, leg type. This rare, cutaneous lymphoma affects predominantly elderly females. Clinically, patients present
An. Bras. Dermatol.. Publicado em: 2014-07
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36. Evaluation of the mutagenicity and antimutagenicity of Ziziphus joazeiro Mart. bark in the micronucleus assay
The aim of this study was to evaluate the mutagenicity (clastogenicity/aneugenicity) of a glycolic extract of Ziziphus joazeiro bark (GEZJ) by the micronucleus assay in mice bone marrow. Antimutagenic activity was also assessed using treatments associated with GEZJ and doxorubicin (DXR). Mice were evaluated 24-48 h after exposure to positive (N-nitroso-N-eth
Genet. Mol. Biol.. Publicado em: 2014-06