Serious stomatitis and esophagitis: a peculiar mucous reaction induced by pegylated liposomal doxorubicin

AUTOR(ES)

Ma, Han, Chen, Meilan, Liu, Junru, Li, Ying, Li, Juan

FONTE

An. Bras. Dermatol.

DATA DE PUBLICAÇÃO

2015-06

RESUMO

AbstractPegylated liposomal doxorubicin is an important antineoplastic agent with activity in a variety of solid tumors. It has a totally different profile of pharmacokinetics and toxicity compared with doxorubicin. It rarely causes side-effects like cardiotoxicity or hair loss, but frequently results in many kinds of mucocutaneous reactions, including palmar-plantar erythrodysesthesia, diffuse follicular rash, intertrigo-like eruption, new formation of melanotic macules, stomatitis and radiation recall dermatitis. We present a rare case of multiple myeloma who immediately developed serious stomatitis and esophatitis associated with minor palmar-plantar erythrodysesthesia after a single course of pegylated liposomal doxorubicin.

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