Doxorubicin
Mostrando 37-48 de 285 artigos, teses e dissertações.
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37. Involvement of miR-30c in resistance to doxorubicin by regulating YWHAZ in breast cancer cells
MicroRNAs (miRNAs) are small RNA molecules that modulate gene expression implicated in cancer, which play crucial roles in diverse biological processes, such as development, differentiation, apoptosis, and proliferation. The aim of this study was to investigate whether miR-30c mediated the resistance of breast cancer cells to the chemotherapeutic agent doxor
Braz J Med Biol Res. Publicado em: 10/01/2014
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38. Outcomes of autologous transplantation for multiple myeloma according to different induction regimens
Background: Induction therapy followed by high-dose chemotherapy and autologous transplantation is the standard treatment for suitable patients with multiple myeloma. Objective: The aim of this study was to assess whether induction therapy with thalidomidecontaining regimens was associated with improved results compared to vincristine, doxorubicin, and
Rev. Bras. Hematol. Hemoter.. Publicado em: 2014-01
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39. RNAi-mediated knockdown of FANCF suppresses cell proliferation, migration, invasion, and drug resistance potential of breast cancer cells
Fanconi anemia complementation group F protein (FANCF) is a key factor, which maintains the function of FA/BRCA, a DNA damage response pathway. However, the functional role of FANCF in breast cancer has not been elucidated. We performed a specific FANCF-shRNA knockdown of endogenous FANCF in vitro. Cell viability was measured with a CCK-8 assay. DNA damage w
Braz J Med Biol Res. Publicado em: 12/12/2013
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40. Antiproliferative activity of Eremanthus crotonoides extracts and centratherin demonstrated in brain tumor cell lines
The genus Eremanthus is recognized by the predominance of sesquiterpene lactones from the furanoheliangolide type, a class of substances extensively tested against cancer cell lines. Thus, the species E. crotonoides (DC.) Sch. Bip., Asteraceae, obtained on "restinga" vegetation was evaluated against U251 and U87-MG glioma cell lines using the MTT colorimetri
Rev. bras. farmacogn.. Publicado em: 16/11/2012
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41. Linfoma esofágico primário
We describe the case of a 54 year old woman seen with an esophageal mass diagnosed as a primary esophageal lymphoma. The main symptom was dysphagia of seven months duration. The treatment consisted in resection of the tumor, and reconstruction of the defect with a reversed pleural flap, followed by a chemotherapy regimen that consisted of five drugs, cycloph
Revista do Colégio Brasileiro de Cirurgiões. Publicado em: 2012-06
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42. Co-culture of apoptotic breast cancer cells with immature dendritic cells: a novel approach for DC-based vaccination in breast cancer
A dendritic cell (DC)-based vaccine strategy could reduce the risk of recurrence and improve the survival of breast cancer patients. However, while therapy-induced apoptosis of hepatocellular and colorectal carcinoma cells can enhance maturation and antigen presentation of DCs, whether this effect occurs in breast cancer is currently unknown. In the present
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-06
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43. A conjugate of an anti-midkine single-chain variable fragment to doxorubicin inhibits tumor growth
Doxorubicin (DOX) was conjugated to a single-chain variable fragment (scFv) against human midkine (MK), and the conjugate (scFv-DOX) was used to target the chemotherapeutic agent to a mouse solid tumor model in which the tumor cells expressed high levels of human MK. The His-tagged recombinant scFv was expressed in bacteria, purified by metal affinity chroma
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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44. Avaliação da combinação de BDNF e quimioterapia em células de câncer de ovário (OVCAR-3)
Introdução: O câncer de ovário é o mais prevalente e letal câncer ginecológico. A quimioterapia é um componente importante do tratamento sistêmico clássico com uma combinação de um agente platinado e um taxano, usualmente. Invariavelmente, câncer de ovário avançado torna-se resistente à quimioterapia. Objetivos: Com base em dados recentes que
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2012
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45. Estudo do metabolismo de microRNAs na resistência de células leucêmicas / Study of microRNA metabolism in leukemik cells resistance
Drug resistance is one of the main obstacles in cancer therapy. Frequently, the treatment of chronic myelogenous leukemia (CML) becomes inefficient due to the emergence of a resistant population of cancer cells. Therefore, comparative studies of resistant and non-resistant CML cell lines is extremely important to the understanding of molecular mechanisms inv
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/07/2011
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46. Atividade anticâncer in vitro e in vivo de Psidium guajava L. (nome popular: goiabeira) / Psidium guajava L. (popular name guava) in vitro and in vivo anticancer activity
Anticancer drug research based on screening of natural sources enabled the discovery of several drugs that are used in cancer treatment. This project aimed to evaluate the in vitro and in vivo anticancer activity of Psidium guajava L. (popular name: guava), elected for its ethnopharmacological use for antiparasitic activity. After harvesting, the vegetal mat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 16/02/2011
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47. In vitro cytotoxic activity of Brazilian Middle West plant extracts
Cytotoxic activity of eight plant extracts, native from the Mid-West of Brazil comprising Cerrado, Pantanal and semideciduous forest, was evaluated for MDA-MB-435, SF-295, and HCT-8 cancer cell strains. A single 100 µg.mL-1 dose of each extract was employed with 72 h of incubation for all tests. Doxorubicin (1 µg.mL-1) was used as the positive control and
Revista Brasileira de Farmacognosia. Publicado em: 15/04/2011
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48. Análise do perfil de expressão gênica de linhagens epiteliais mamárias humanas submetidas ao tratamento com rapamicina associada à doxorrubicina / Gene expression analysis of human breast epithelial cell lines treated with the combination of rapamycin and doxorubicin
A resistência à quimioterapia, a qual se constitui em um dos maiores desafios a serem superados durante o tratamento do cancer de mama, pode ser modulada por várias cascatas de sinalização cellular que levam ao aumento da sobrevivência celular. A via PI3K/Akt/mTOR é uma importante reguladora desse processo, visto que ela pode favorecer o crescimento t
Publicado em: 2011