Dose Response Relationship Drug
Mostrando 1-12 de 34 artigos, teses e dissertações.
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1. Effects of the administration of a catalase inhibitor into the fourth cerebral ventricle on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke
OBJECTIVE: Previous studies have demonstrated a relationship between brain oxidative stress and cardiovascular regulation. We evaluated the effects of central catalase inhibition on cardiovascular responses in spontaneously hypertensive rats exposed to sidestream cigarette smoke. METHODS: Male Wistar Kyoto (WKY) rats and spontaneously hypertensive rats (S
Clinics. Publicado em: 2013-06
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2. Diretrizes para prevenção e tratamento da osteoporose induzida por glicocorticoide
Os glicocorticoides (GC) são prescritos por praticamente todas as especialidades médicas, e cerca de 0,5% da população geral do Reino Unido utiliza esses medicamentos. Com o aumento da sobrevida dos pacientes com doenças reumatológicas, a morbidade secundária ao uso dessa medicação representa um aspecto importante que deve ser considerado no manejo
Revista Brasileira de Reumatologia. Publicado em: 2012-08
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3. Análise de fatores relacionados à resistência ao tratamento com drogas anti-epilepticas em epilepsia de lobo temporal mesial / Analysis of factors related to anti-epileptic drug resistance in mesial temporal lobe epilepsy
The objective of the present work was to investigate the relationship between brain MRI and clinical characteristics and patterns of antiepileptic drug (AED) response in patients with mesial temporal lobe epilepsy (MTLE).In order to do that,one hundred sixty five MTLE patients were divided into seizure-free with AED (50 AEDresponders, 31 women), 87 pharmacor
Publicado em: 2011
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4. Doxorrubicina e ifosfamida em dose densa em pacientes com sarcomas de partes moles e expressão de ezrina como fator de prognóstico / Doxorrubicina e ifosfamida em dose densa em pacientes com sarcomas de partes moles e expressão de ezrina como fator de prognóstico
O prognóstico de pacientes portadores de sarcomas de partes moles (SPM) avançados é reservado. Aumentar o benefício de quimioterapia é necessário, sendo, uma das estratégias, quimioterapia em dose densa, a qual demonstrou benefício em câncer de mama. Por outro lado, a busca de um marcador prognóstico é importante para uma melhor seleção de pacie
Publicado em: 2010
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5. Ação de drogas agonistas e antagonistas dos sistemas colinérgico e dopaminégico: estudo comportamental e neuroquímico em corpo estriado de rato. / The action of the agonists and antagonists drugs of cholinergic and dopaminergic systems: behavioral and neurochemical study in striatum of rats
In the study, the interaction between the dopaminergic and cholinergic systems through the study of behavioral (open field and catalepsy) and neurochemical (density of dopaminergic receptor (D1 and D2-like) and muscarinic (M1+M2-like)) effect in striatum rat was evaluated. The following drugs were used: mazindol (indirect dopaminergic agonist), apomorphine (
Publicado em: 2005
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6. Novas pirimidinas: sÃntese e avaliaÃÃo de suas propiedades farmacolÃgicas
This work describes the synthesis of three series of compounds with pirimidinic ring and its pharmacological evaluations. First, the synthesis of compounds 4-amino-2,6-(diaryldissubistituted)- 5-carbonitrile-pyrimidines (5a-h) were achieved starting from arylamidine and bisnitriles. Second, the nitro-compounds (5k-o) have been reduced to their respective ami
Publicado em: 2003
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7. Efeitos do n-p (Azido-M- iodofeniletilamidoisobutil) Noradrenalina (Nain) "In Vivo e In Vitro" : um agonista de adrenoceptores beta
The selectivity of NAIN as a beta-adrenoceptor agonist was studied "in vivo" and "in vitro". The effects of the drug on arterial pressure and heart rate in conscious rats were compared with those obtained using isoproterenol. The pA2 value, obtained in isolated guinea-pig right atria for propranolol was compared to that obtained for metoprolol. The results f
Publicado em: 1992
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8. Comparative low-dose nephrotoxicities of gentamicin, tobramycin, and amikacin.
Most investigations of the comparative nephrotoxicities of aminoglycosides in animals have utilized large multiples of the human dose. Furthermore, many of these assessments have used only one or two dose levels and have not described a dose-response comparison among antibiotics. Because of this lack of comparative dose-response data over a range of low mult
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9. Pharmacodynamics of Fluoroquinolones against Streptococcus pneumoniae in Patients with Community-Acquired Respiratory Tract Infections
Fluoroquinolone antibiotic agents have demonstrated efficacy in the treatment of respiratory tract infections. This analysis was designed to examine the relationship between drug exposure, as measured by the free-drug area under the concentration-time curve at 24 h (AUC24)/MIC ratio, and clinical and microbiological responses in patients with community-acqui
American Society for Microbiology.
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10. To scale or not to scale: the principles of dose extrapolation
The principles of inter-species dose extrapolation are poorly understood and applied. We provide an overview of the principles underlying dose scaling for size and dose adjustment for size-independent differences. Scaling of a dose is required in three main situations: the anticipation of first-in-human doses for clinical trials, dose extrapolation in veteri
Blackwell Publishing Ltd.
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11. Diabetogenic action of streptozotocin: relationship of dose to metabolic response
The relationship between the dose of intravenously administered streptozotocin (a N-nitroso derivative of glucosamine) and the diabetogenic response has been explored by use of the following indices of diabetogenic action: serum glucose, urine volume, and glycosuria, ketonuria, serum immunoreactive insulin (IRI), and pancreatic IRI content. Diabetogenic acti
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12. Randomized double-blind evaluation of ceftazidime dose ranging in hospitalized patients with cystic fibrosis.
Eighty-five patients with cystic fibrosis who were experiencing an acute infectious exacerbation of their disease were randomized in double-blind fashion to receive either 50 or 75 mg of ceftazidime per kg (body weight) per dose administered intravenously every 8 h for 14 days. Three patients were dropped from the study within 4 days of enrollment for reason