Ação de drogas agonistas e antagonistas dos sistemas colinérgico e dopaminégico: estudo comportamental e neuroquímico em corpo estriado de rato. / The action of the agonists and antagonists drugs of cholinergic and dopaminergic systems: behavioral and neurochemical study in striatum of rats

AUTOR(ES)

Emmanuelle Coelho Noronha

DATA DE PUBLICAÇÃO

2005

RESUMO

In the study, the interaction between the dopaminergic and cholinergic systems through the study of behavioral (open field and catalepsy) and neurochemical (density of dopaminergic receptor (D1 and D2-like) and muscarinic (M1+M2-like)) effect in striatum rat was evaluated. The following drugs were used: mazindol (indirect dopaminergic agonist), apomorphine (D1-like and D2-like dopaminergic agonist), pilocarpine (M1-like muscarnic aginist), carbachol (M-2like agonist muscarinc), pirenzepine (M1-like antagonist muscarinic), atropine (non-selective M1 and M2 antagonist muscarinic), clozapina(non-typical neuroleptic). The results showed that the pimozida and carbachol, alone or associated, caused increase in the cataleptic response and reduction in the motor activity. The mazindol also increased the motor activity. In small dosage, the carbachol and mazindol increased the density of D1-like receptors. Isolated, the pimozida and atropine increased the density of the D1-like receptors in striatum whereas the atropine caused a reduction of D2-like receptors and upregulation of muscarinic receptors. This work suggests a relationship, between muscarinc receptors M1 and M2 and dopaminergic receptors D1 and D2, and that this relationship can occur in a positive and negative manner, depending on the selectivity and the dose of the used drug

ASSUNTO(S)

acetilcolina arecolina neurotransmissores beravioral receptores muscarínicos dopamina sistema nervoso central acetylcholine farmacologia agonistas muscarínicos comportamento dopamine

Documentos Relacionados

• Evaluation of the central effects of yangambin isolated from Ocotea duckei Vattimo: Behavioral and neurochemical study in mice motor cortex and striatum
• Local circuit neurons in the striatum regulate neural and behavioral responses to dopaminergic stimulation
• Behavioral and neurochemical differentiation of specific projections in the septal-hippocampal cholinergic pathway of the rat.
• Novos aspectos da aÃÃo de drogas antiepilÃpticas: efeitos antioxidantes e modulaÃÃo dos sistemas colinÃrgico e dopaminÃrgico.
• Buspirona aumenta a densidade de receptores dopaminérgicos D2- símile em corpo estriado de rato