Cytoskeleton
Mostrando 25-36 de 1553 artigos, teses e dissertações.
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25. Vias de sobrevivência e morte em queratinócitos submetidos ao estresse oxidativo e choque hiperosmótico / Survival and death signaling pathways in keratinocytes exposed to oxidative stress and hyperosmotic shock
The epidermis is constantly confronted with multiple environmental stressors. Changes in humidity or exposition to UV radiation affect the redox state and osmotic balance, modifying the physiological characteristics of the skin. In response to different stresses, epidermal keratinocytes can activate distinct signaling pathways and the balance between death a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 27/06/2011
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26. ARHGAP21 inibe a secreção de insulina estimulada por glicose através da modulação aa FAK, CDC42 E PKC dzeta / ARHGAP21 inhibits glucose-stimulated insulin secretion through through FAK, CDC42 and PKC dzeta
Background/Aims: ARHGAP21 is a Rho-GAP that promotes activation of the Rho-GTPase Cdc42 intrinsic factor, which is responsible for the hydrolysis of GTP to GDP and those proteins inactivation. ARHGAP21 associates with PKC? in cardiomyocytes and to the C-terminal portion of FAK in glioblastoma, inhibiting Rho-GTPases and actin cytoskeleton rearrangement. Cdc4
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/06/2011
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27. Avaliação da expressão e localização da conexina 43 na injúria isquêmica renal aguda / Evaluation of Connexin 43 expression and localization in renal acute ischemic injury
The cells require contact with other cells and the extracellular matrix for tissue formation. Gap junctions are narrow channels connecting the cytoplasm of two adjacent cells, promoting the passage of inorganic ions, amino acids, nucleotides and other metabolites. These junctions are composed of two conexons or hemichannels, crossing the cell plasma membrane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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28. Estudos estruturais e funcionais das proteínas cinases humanas Nek1 e Nek6 / Structural and functional studies of Nek1 Nek6 protein kinases
NIMA was identified and functionally characterized in Aspergillus nidulans as a critical Ser/Thr kinase for cell cycle progression. The mammalian Neks (NIMA-related kinases) represent an evolutionarily conserved family of 11 serine/threonine kinases that share 40-45% identity with NIMA N-terminal domain. Neks are associated to cell cyclerelated functions and
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 04/03/2011
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29. Trypanosoma cruzi trypomastigotes induce cytoskeleton modifications during HeLa cell invasion
It has been recently shown that Trypanosoma cruzi trypomastigotes subvert a constitutive membrane repair mechanism to invade HeLa cells. Using a membrane extraction protocol and high-resolution microscopy, the HeLa cytoskeleton and T. cruzi parasites were imaged during the invasion process after 15 min and 45 min. Parasites were initially found under cells a
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-12
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30. Hypothyroidism decreases proinsulin gene expression and the attachment of its mRNA and eEF1A protein to the actin cytoskeleton of INS-1E cells
The actions of thyroid hormone (TH) on pancreatic beta cells have not been thoroughly explored, with current knowledge being limited to the modulation of insulin secretion in response to glucose, and beta cell viability by regulation of pro-mitotic and pro-apoptotic factors. Therefore, the effects of TH on proinsulin gene expression are not known. This led u
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-10
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31. Vimentin and laminin are altered on cheek pouch microvessels of streptozotocin-induced diabetic hamsters
OBJECTIVE: Normal endothelial cells respond to shear stress by elongating and aligning in the direction of fluid flow. Hyperglycemia impairs this response and contributes to microvascular complications, which result in deleterious effects to the endothelium. This work aimed to evaluate cheek pouch microvessel morphological characteristics, reactivity, permea
Clinics. Publicado em: 2011
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32. Estudo de genes do Sistema de Secreção tipo VI em uma linhagem de Escherichia coli patogênica para aves (APEC) / Study of Type VI Secretion System genes in an avian Escherichia coli pathogenic strain (APEC)
Avian pathogenic Escherichia coli (APEC) strains frequently cause extraintestinal infections and are responsible for significant economic losses in the poultry industry worldwide. APEC isolates are closely related to human extraintestinal pathogenic E. coli (ExPEC) strains and may also act as pathogens for humans. Known APEC virulence factors include adhesin
Publicado em: 2011
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33. Estudo da suscetibilidade de amastigotas extracelulares das cepas G e CL de Trypanosoma cruzi a componentes do sistema imune inato e adaptativo. Avaliação da atividade pró-fagocítica da P21-His6
Trypanosoma cruzi é o agente etiológico da doença de Chagas. Devido à ampla diversidade genética existente em T. cruzi, a espécie foi dividida em seis discretas unidades de tipagem (DTU), denominadas T.cruzi I a VI. A cepa G pertence ao grupo T.cruzi I e a CL a T.cruzi VI. Formas amastigotas extracelulares (AE) são consideradas importantes na manuten�
Publicado em: 2011
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34. A transcriptome analysis of mitten crab testes (Eriocheir sinensis)
The identification of expressed genes involved in sexual precocity of the mitten crab (Eriocheir sinensis) is critical for a better understanding of its reproductive development. To this end, we constructed a cDNA library from the rapid developmental stage of testis of E. sinensis and sequenced 3,388 randomly picked clones. After processing, 2,990 high-quali
Genetics and Molecular Biology. Publicado em: 19/11/2010
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35. Efeitos da administração intraestriatal aguda de ácido quinolítico sobre o citoesqueleto de células neurais de ratos
In the present study we investigated the effect of in vivo intrastriatal injection of quinolinic acid (QA) on rat cytoskeleton proteins in astrocytes and neurons of young rats at early stages (30 min) after infusion. Intrastriatal QA injection is an excitotoxic model of Huntington´s Disease (HD). Results showed that QA (150¿mol/0.5¿L) significantly increa
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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36. Efeitos da inibição de Aurora A sobre a proliferação e fenótipo de células derivadas de hepatocarcinoma humano. / A inhibition effects in proliferation and morphology in cells derivated of Hepatocellular Carcinoma.
Hepatocarcinoma (HCC) é o mais comum tumor maligno primário do fígado. Aurora A é importante durante o ciclo celular, atuando na maturação centrossômica e sua separação, entrada em mitose, montagem de fuso bipolar, alinhamento dos cromossomos na placa metafásica e citocinese. Expressão alterada de Aurora A tem sido associada com o desenvolvimento
Publicado em: 2010