Cytokine Release
Mostrando 13-24 de 470 artigos, teses e dissertações.
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13. Análise da citotoxicidade do hipoclorito de sódio a 1%, do digluconato de clorexidina a 2% e do endoquil e seus efeitos na liberação de citocinas e óxido nítrico em culturas de macrófagos murinos / Cytotoxicity analysis of 1% sodium hypochlorite, of 2% chlorhexidine digluconate and of Endoquil and its effects on release of cytokine and nitric oxide in cultured murine macrophages
Avaliou-se a citotoxicidade do hipoclorito de sódio a 1%, do digluconato de clorexidina a 2% e do Endoquil e seus efeitos na liberação de citocinas e de óxido nítrico em culturas de macrófagos peritoniais murinos. As substâncias sofreram diluições de 1.000 e 10.000 vezes: Grupo Controle, meio de cultura meio McCoy`s 5A® modificado e apirogênico; G
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 03/02/2011
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14. High-density lipoprotein prevents SAA-induced production of TNF-α in THP-1 monocytic cells and peripheral blood mononuclear cells
In this study, we evaluated whether human serum and lipoproteins, especially high-density lipoprotein (HDL), affected serum amyloid A (SAA)-induced cytokine release. We verified the effects of SAA on THP-1 cells in serum-free medium compared to medium containing human serum or lipoprotein-deficient serum. SAA-induced tumour necrosis factor-alpha (TNF-α) pro
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-12
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15. Effect of titanium surface on secretion of IL1β and TGFβ1 by mononuclear cells
Mononuclear cells play an important role in the modulation of healing. The characteristics of implant surface topography may alter the production of signaling molecules such as cytokines. The aim of this in vitro study was to evaluate the effects of commercially available titanium surface treatments on both cell viability and the secretion of the antagonist
Brazilian Oral Research. Publicado em: 2011-12
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16. Endothelial dysfunction in cardiovascular and endocrine-metabolic diseases: an update
The endothelium plays a vital role in maintaining circulatory homeostasis by the release of relaxing and contracting factors. Any change in this balance may result in a process known as endothelial dysfunction that leads to impaired control of vascular tone and contributes to the pathogenesis of some cardiovascular and endocrine/metabolic diseases. Reduced e
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-09
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17. A high corticosterone/DHEA-s ratio in young rats infected with Trypanosoma cruzi is associated with increased susceptibility
We have previously established that young male rats are more susceptible to the effects of Trypanosoma cruzi infection than adult rats. To explore underlying age-associated differences in disease outcome, we simultaneously assessed hormone levels and cytokine release throughout the acute infection period in young and adult rats infected with T. cruzi. Young
Memórias do Instituto Oswaldo Cruz. Publicado em: 2011-06
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18. In vivo and in vitro anti-inflammatory and anti-nociceptive activities of lovastatin in rodents
Statins are among the most prescribed drugs in recent clinical practice. They are also known for their pleiotropic actions, which are independent of their lipid-lowering properties. The effect of lovastatin was investigated against carrageenan-induced paw edema in male Wistar rats (200-250 g) and on leukocyte migration, as measured by carrageenan-induced per
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-02
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19. Antipyretic and antioxidant activities of 5-trifluoromethyl-4,5-dihydro-1H-pyrazoles in rats
The objective of this study was to determine the effect of eight 5-hydroxy-5-trifluoromethyl-4,5-dihydro-1H-1-carboxyamidepyrazoles (TFDPs) on rat body temperature and baker’s yeast-induced fever. TFDPs or vehicle (5% Tween 80 in 0.9% NaCl, 5 mL/kg) were injected subcutaneously and rectal temperature was measured as a function of time in 28-day-old male Wi
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-12
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20. Interleukin-15 augments oxidative metabolism and fungicidal activity of human monocytes against Paracoccidioides brasiliensis
Interleukin (IL)-15 is a pleiotropic cytokine that regulates the proliferation and survival of many cell types. IL-15 is produced by monocytes and macrophages against infectious agents and plays a pivotal role in innate and adaptive immune responses. This study analyzed the effect of IL-15 on fungicidal activity, oxidative metabolism and cytokine production
Memórias do Instituto Oswaldo Cruz. Publicado em: 2010-11
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21. Lung hyperinflation stimulates the release of inflammatory mediators in spontaneously breathing subjects
Lung hyperinflation up to vital capacity is used to re-expand collapsed lung areas and to improve gas exchange during general anesthesia. However, it may induce inflammation in normal lungs. The objective of this study was to evaluate the effects of a lung hyperinflation maneuver (LHM) on plasma cytokine release in 10 healthy subjects (age: 26.1 ± 1.2 years
Brazilian Journal of Medical and Biological Research. Publicado em: 2010-02
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22. Evaluation on the involvement of Galatrox, a lactose binding lectin isolated from Bothrops atrox venom, on the inflammatory process / Avaliação do envolvimento da Galatrox, uma lectina ligante de lactodr isolada da peçonha de Bothrops atrox, no processo inflamatório
Lectins are proteins with no enzymatic activity and are able to bind specifically and non-covalently (reversible manner) to carbohydrates. In addition, these proteins are involved in several physiological and pathological events, as embryogenesis, immune response, cancer, and others. Galatrox, a lactose-binding protein, was purified from Bothrops atrox snake
Publicado em: 2010
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23. Impact of galectin-1 on the evolution of acute experimental Trypanosoma cruzi infection / Avaliação da participação da galectina-1 na evolução da infecção experimental aguda por Trypanosoma cruzi
Galectin-1 (Gal-1) is a -galactoside-binding protein and participates in several biological processes, including modulation of immune response. In the literature, there are several reports about the potential therapeutic use of Gal-1 for autoimmune diseases, inflammatory, degenerative and infectious diseases. However, there are few reports on the involvement
Publicado em: 2010
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24. Study of regulatory and proinflammatory factors in chronic idiopathic urticaria and in vitro immunomodulatory effect of statins / Estudo dos fatores regulatórios e pró-inflamatórios na urticária crônica idiopática e efeito imunomodulatório in vitro das estatinas
INTRODUCTION: Chronic Idiopathic Urticaria (CIU) is a disease triggered by degranulation of basophils and mast cells with consequent histamine release and the CIU immunological profile is not well established. Statins, 3-hydroxy-3-methylglutaryl coenzyme A reductase inhibitors, also display a broad immunomodulatory property. Statins have been studied in seve
Publicado em: 2010