Cytokine Release
Mostrando 25-36 de 470 artigos, teses e dissertações.
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25. High mobility group box 1 as a mediator of endotoxin administration after hemorrhagic shock-primed lung injury
High mobility group box 1 (HMGB1) was discovered as a novel late-acting cytokine that contributes to acute lung injury (ALI). However, the contribution of HMGB1 to two-hit-induced ALI has not been investigated. To examine the participation of HMGB1 in the pathogenesis of ALI caused by the two-hit hypothesis, endotoxin was injected intratracheally in a hemorr
Brazilian Journal of Medical and Biological Research. Publicado em: 31/07/2009
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26. A influência do nano-recobrimento de cálcio e fósforo no processo de osteogênese in vitro
In vivo studies have reported that reduced dimensions bioactive ceramic coating overcomes the advantages of the PHSA. The aims of this study were to determine the effect of a uniform bioceramic coating in the nanothickness range onto a moderately rough surface on human harvested bone cells cultivated isolated or in coculture (osteogenic cells and PBMC). The
Publicado em: 2009
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27. Avaliação do papel da galectina-3 sobre funções de neutrófilos durante a infecção por cepa virulenta RH de Toxoplasma gondii em camundongos C57BL/6
Galectins are beta-galactoside-binding animal lectins involved in several biological processes, and Gal-3 has been related to modulation of immune reactions and inflammatory responses. The present study aimed to evaluate the influence of Gal-3 in neutrophil viability, early apoptosis and cell death in parallel with its biological functions after in vivo and
Publicado em: 2009
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28. Stress-induced neuroinflammation: mechanisms and new pharmacological targets
Stress is triggered by numerous unexpected environmental, social or pathological stimuli occurring during the life of animals, including humans, which determine changes in all of their systems. Although acute stress is essential for survival, chronic, long-lasting stress can be detrimental. In this review, we present data supporting the hypothesis that stres
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-12
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29. BAY 41-2272: potential immunomodulator to control infections. / BAY 41-2272: um imunomodulador com potencial para o controle de infecções.
Phagocyte activation is critical role for host defense against several pathogens, so that studies developing alternatives for activating these cell are very important. We investigated the effects of BAY 41-2272 on phagocytes activation. For this purpose we evaluated several aspects indicating cellular activation, as phagocytosis, superoxide release and micro
Publicado em: 2008
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30. Hospital malnutrition and inflammatory response in critically ill children and adolescents admitted to a tertiary intensive care unit
Critical illness has a major impact on the nutritional status of both children and adults. A retrospective study was conducted to evaluate the incidence of hospital malnutrition at a pediatric tertiary intensive care unit (PICU). Serum concentrations of IL-6 in subgroups of well-nourished and malnourished patients were also evaluated in an attempt to identif
Clinics. Publicado em: 2008
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31. Insights of local tissue damage and regeneration induced by BnSP-7, a myotoxin isolated from Bothrops pauloensis snake venom: A study of release of pro-inflammatory cytokines and expression of Matrix Metalloproteinases (MMP2 and MMP9). / Aspectos da lesão tecidual local e da regeneração induzidas pela BnSP-7, uma miotoxina isolada da peçonha da serpente Bothrops pauloensis: um estudo da liberação de citocinas pró-inflamatórias e da expressão de metaloproteases de matriz (MMP-9 e MMP-2)
Envenenamentos causados por serpentes do gênero Bothrops São caracterizados por lesão tecidual local proeminente devido à mionecrose, hemorragia e edema. A lesão tecidual aguda induzida por essas peçonhas ocorre devido à ação de diferentes toxinas presentes nas peçonhas, entre elas as fosfolipases A2 (PLA2) miotóxicas possuem um importante papel.
Publicado em: 2008
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32. Tuberculose: estudo da formaÃÃo de padrÃes na eliminaÃÃo, contenÃÃo e disseminaÃÃo do bacilo de Koch
Tuberculosis (TB) is an endemic disease caused by an aerobic bacterium named Mycobacterium tuberculosis (Mtb). It is responsible for on third of population infected worldwide and it causes 2.2 millions deaths per year. The most common infection by Mtb occurs by inhalation of microorganisms into the lungs, where they infect mainly alveolar macrophages. The in
Publicado em: 2007
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33. Leptospira interrogans activation of peripheral blood monocyte glycolipoprotein demonstrated in whole blood by the release of IL-6
Glycolipoprotein (GLP) from pathogenic serovars of Leptospira has been implicated in the pathogenesis of leptospirosis by its presence in tissues of experimental animals with leptospirosis, the inhibition of the Na,K-ATPase pump activity, and induced production of cytokines. The aims of the present study were to investigate the induction of IL-6 by GLP in pe
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-06
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34. Mechanisms of eosinophil cytokine release
Human eosinophils have been demonstrated to contain a multitude of cytokines and chemokines that exist pre-formed within these cells. This content of pre-formed cytokines, with diverse potential biologic activities, provides eosinophils with capabilities distinct from most other leukocytes. The localization of pre-formed cytokines within eosinophils is both
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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35. The balance between the production of tumor necrosis factor-alpha and interleukin-10 determines tissue injury and lethality during intestinal ischemia and reperfusion
A major goal in the treatment of acute ischemia of a vascular territory is to restore blood flow to normal values, i.e. to "reperfuse" the ischemic vascular bed. However, reperfusion of ischemic tissues is associated with local and systemic leukocyte activation and trafficking, endothelial barrier dysfunction in postcapillary venules, enhanced production of
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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36. Experimental murine mycobacteriosis: evaluation of the functional activity of alveolar macrophages in thalidomide- treated mice
Thalidomide is a selective inhibitor of tumor necrosis factor-alpha (TNF-alpha), a cytokine involved in mycobacterial death mechanisms. We investigated the role of this drug in the functional activity of alveolar macrophages in the presence of infection induced by intranasal inoculation of Mycobacterium avium in thalidomide-treated and untreated adult Swiss
Brazilian Journal of Medical and Biological Research. Publicado em: 2004-04