Cyclic Amp
Mostrando 13-24 de 2761 artigos, teses e dissertações.
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13. Caracterização da expressão e função de receptores recombinantes do hormônio folículo-estimulante. / Characterization of expression and function of recombinant follicle-stimulating receptors.
The follicle stimulating hormone receptor (FSHR) is a member of a family of Gprotein-coupled receptors that has a large aminoterminal domain, rich in leucine repeats. The FSHR, together with the luteinizing hormone receptor, controls gonadal function in vertebrates. Mutations in the FSHR can alter its binding and signaling properties, and drastically affect
Publicado em: 2006
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14. Selective PDE4 inhibitors as potent anti-inflammatory drugs for the treatment of airway diseases
Phosphodiesterases (PDEs) are responsible for the breakdown of intracellular cyclic nucleotides, from which PDE4 are the major cyclic AMP metabolizing isoenzymes found in inflammatory and immune cells. This generated greatest interest on PDE4 as a potential target to treat lung inflammatory diseases. For example, cigarette smoke-induced neutrophilia in BAL w
Memórias do Instituto Oswaldo Cruz. Publicado em: 2005-03
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15. Identification of casein kinase 1, casein kinase 2, and cAMP-dependent protein kinase-like activities in Trypanosoma evansi
Trypanosoma evansi contains protein kinases capable of phosphorylating endogenous substrates with apparent molecular masses in the range between 20 and 205 kDa. The major phosphopolypeptide band, pp55, was predominantly localized in the particulate fraction. Anti-alpha and anti-beta tubulin monoclonal antibodies recognized pp55 by Western blot analyses, sugg
Memórias do Instituto Oswaldo Cruz. Publicado em: 2004-12
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16. Responsiveness of glycogen breakdown to cyclic AMP in perfused liver from rats with insulin-induced hypoglycemia
The responsiveness of glycogen breakdown to cAMP was investigated in isolated perfused liver from male Wistar fed rats (200-220 g) with insulin-induced hypoglycemia. The activation of glycogenolysis by 3 µM cAMP was decreased (P<0.05) in livers from rats with hypoglycemia induced by the administration of insulin or during the direct infusion of insulin into
Brazilian Journal of Medical and Biological Research. Publicado em: 2003-01
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17. Adenylyl cyclase types I and VI but not II and V are selectively inhibited by nitric oxide
Adenylyl cyclase (AC) isoforms catalyze the synthesis of 3',5'-cyclic AMP from ATP. These isoforms are critically involved in the regulation of gene transcription, metabolism, and ion channel activity among others. Nitric oxide (NO) is a gaseous product whose synthesis from L-arginine is catalyzed by the enzyme NO synthase. It has been well established that
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-02
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18. Cyclic AMP increases the survival of ganglion cells in mixed retinal cell cultures in the absence of exogenous neurotrophic molecules, an effect that involves cholinergic activity
Natural cell death is a well-known degenerative phenomenon occurring during development of the nervous system. The role of trophic molecules produced by target and afferent cells as well as by glial cells has been extensively demonstrated. Literature data demonstrate that cAMP can modulate the survival of neuronal cells. Cultures of mixed retinal cells were
Brazilian Journal of Medical and Biological Research. Publicado em: 2001-12
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19. Time sequence of changes in the responsiveness of glycogen breakdown to adrenergic agonists in perfused liver of rats with insulin-induced hypoglycemia
The time-course changes of the responsiveness of glycogen breakdown to a- and ß-adrenergic agonists during insulin-induced hypoglycemia (IIH) were investigated. Blood glucose levels were decreased prior to the alteration in the hepatic responsiveness to adrenergic agonists. The activation of hepatic glucose production and glycogenolysis by phenylephrine (2
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-07
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20. Estudo do efeito da dobutamina (Dobutrex) R e da radiação laser sobre a ação hidrosmotica da vasopressina em bexiga de sapo "in vitro"
In the present work the effects of several pharmacological agents in special Dobutamine and a physical agent-Laser radiation - on the events that follow the interaction of Vasopressin with membrane receptors related to syn¬thesis and inactivation of cyclic-AMP in the toad bladder, are described and characterized. Water flow across the membrane was measured
Publicado em: 1991
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21. Estudo do efeito de agentes adrenergicos sobre a atuação da vasopressina (Pitressin) na estimulação do fluxo de agua atraves da bexiga de sapo "in vitro"
The present work corre lates adrenergic receptor manipulation by several pharmacological agents to the hydromotic response oi the toad urinary bladder to vasopressin. Water flow was measured by the technique of BENTLEY (1958) (3) which consists of the gravimetric determination of the volume flow when an osmotic pressure difference is imposed between the two
Publicado em: 1987
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22. Cyclic AMP binding proteins and cyclic AMP-dependent protein kinase from Blastocladiella emersonii.
The stoichiometry of cyclic AMP binding protein to cyclic AMP in sporulating cells of Blastocladiella emersonii and the resistance of protein-bound cyclic AMP to enzyme-catalyzed hydrolysis suggest that the distribution of cyclic AMP between free and protein-bound pools is an important factor in cyclic AMP metabolism. Most but not all of the cyclic AMP bindi
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23. Studies of the elevated extracellular concentration of cyclic AMP in uremic man.
This study was designed to elucidate the mechanism of elevation of plasma cyclic AMP in uremic man. Plasma cyclic AMP was measured in 15 normal subjects and in 18 patients with severe renal failure. In some members from both groups the kinetic parameters of the metabolism of extracellular cyclic AMP were measured. Plasma cyclic AMP was elevated from 23 nM in
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24. RADIOIMMUNOASSAY FOR THE MEASUREMENT OF ADENOSINE 3′,5′-CYCLIC PHOSPHATE*
A sensitive and specific radioimmunoassay for adenosine 3′,5′-cyclic phosphate (cyclic AMP) has been developed which allows measurement of the nucleotide in extracts of 5-10 mg of tissue. The radioimmunoassay is sufficiently specific for cyclic AMP to eliminate the need for prior chromatographic separation of the cyclic nucleotide from other tissue nucle