Coronaridine
Mostrando 1-6 de 6 artigos, teses e dissertações.
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1. Cytotoxicity and genotoxicity of coronaridine from Tabernaemontana catharinensis A.DC in a human laryngeal epithelial carcinoma cell line (Hep-2)
Cancer has become a major public health problem worldwide and the number of deaths due to this disease is increasing almost exponentially. In the constant search for new treatments, natural products of plant origin have provided a variety of new compounds to be explored as antitumor agents. Tabernaemontana catharinensis is a medicinal plant that produces alk
Genet. Mol. Biol.. Publicado em: 01/02/2013
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2. Alcalóides indólicos em Peschiera australis (Muell. Arg.) Miers. var. australis
A espécie vegetal P. australis (Muell. Arg.) Miers. var. australis, Apocynaceae foi analisada quanto ao seu conteúdo alcaloídico em suas diversas partes. Foram isolados e caracterizados três alcalóides majoritários: olivacina, nas folhas e cascas das raízes; coronaridina, nas sementes e cascas das raízes e tabersonina, nas sementes.
Publicado em: 2010
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3. Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity
This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae). Among the 27 substances detected 12 were identified as terpenoid-indole alkaloids, 2 steroids and 13 pentacyclic triterpenes. Structures were outlined based on HMQC, COSY, DEPT, 13C, and ¹H
Química Nova. Publicado em: 2008
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4. Isolamento e identicação de alcaloides indolicos de peschiera campestris Rizz (Rizz)
The lnvestigation of leaf, bark ano root extracts of Peschiera campestris, a new species dicovered in Brasilia in Brazil, afforded (-) isovoacangine 1, (-) isovoacristine 2a, (-) coronaridine 3, (-) voacangine 4, (-) voacangine Hydroxyindolenin 5, (-) heyneanine 6, (-) voacamine 7, (-) voaachalotine 8, (-) vobasine 9, (-) 12-methoxy-Nb-methylvoachalotine 10.
Publicado em: 1986
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5. In Vitro Activities of Iboga Alkaloid Congeners Coronaridine and 18-Methoxycoronaridine against Leishmania amazonensis
In previous studies, we demonstrated the leishmanicide effect of coronaridine, a natural indole alkaloid isolated from stem bark of Peschiera australis (Delorenzi et al., Antimicrob. Agents Chemother. 45:1349-1354, 2001). In this study we show the leishmanicidal effect of the synthetic coronaridine and its racemic 18-methoxylated analog, 18-methoxycoronaridi
American Society for Microbiology.
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6. Antileishmanial Activity of an Indole Alkaloid from Peschiera australis
In this study, we show the leishmanicidal effects of a chloroform fraction (CLF) and a purified indole alkaloid obtained from crude stem extract of Peschiera australis against Leishmania amazonensis, a causative agent of cutaneous leishmaniasis in the New World. In a bioassay-guided chemical fractionation, the leishmanicidal activity in CLF completely and ir
American Society for Microbiology.