Chemical constituents from Tabernaemontana catharinensis root bark: a brief NMR review of indole alkaloids and in vitro cytotoxicity

AUTOR(ES)

Pereira, Paulo Sérgio, França, Suzelei de Castro, Oliveira, Paulo Vinicius Anderson de, Breves, Camila Moniz de Souza, Pereira, Sarazete Izidia Vaz, Sampaio, Suely Vilela, Nomizo, Auro, Dias, Diones Aparecida

FONTE

Química Nova

DATA DE PUBLICAÇÃO

2008

RESUMO

This work describes the isolation and structural determination of pharmacological compounds present in the bark of roots of Tabernaemontana catharinensis (Apocynaceae). Among the 27 substances detected 12 were identified as terpenoid-indole alkaloids, 2 steroids and 13 pentacyclic triterpenes. Structures were outlined based on HMQC, COSY, DEPT, 13C, and ¹H NMR data and MS. Spectral data of indole alkaloids were reviewed. An in vitro screening of the extracts and isolated compounds was carried out. Compounds ibogamine (5), 3-oxo-coronaridine (9) and 12-methoxy-4-methylvoachalotine (MMV) demonstrated effective cytotoxicity towards SKBR-3 breast adenocarcinoma and C-8161 human melanoma tumor cell lines.

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