Connexin 43
Mostrando 13-24 de 133 artigos, teses e dissertações.
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13. Flavins promote changes in the extracellular matrix, signal transduction, antioxidant enzymes and metalloproteinases during osteoblast differentiation / Flavinas promovem mudanças na matriz extracelular, vias de transdução de sinal, enzimas antioxidantes e metaloproteinases durante a diferenciação de osteoblastos
Riboflavin (Rb-Vitamin B2) is the precursor of essential flavocoenzymes, flavin mononucleotide (FMN) and flavin adenine dinucleotide (FAD). These coenzymes participate in numerous enzymatic processes dependent on electron transfer reactions that occur in energyproducing, biosynthetic, and detoxifying and electron-scavenging pathways. Increase dietary ribofla
Publicado em: 2009
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14. TNF/TNFR1 signaling up-regulates CCR5 expression by CD8+ T lymphocytes and promotes heart tissue damage during Trypanosoma cruzi infection: beneficial effects of TNF-α blockade
In Chagas disease, understanding how the immune response controls parasite growth but also leads to heart damage may provide insight into the design of new therapeutic strategies. Tumor necrosis factor-alpha (TNF-α) is important for resistance to acute Trypanosoma cruzi infection; however, in patients suffering from chronic T. cruzi infection, plasma TNF-α
Mem. Inst. Oswaldo Cruz. Publicado em: 2008-06
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15. Expression of gap junction proteins, the connexins, in normal and neoplastic osseous tissues from dogs / Estudo da expressão das proteínas de junções intercelulares do tipo Gap, as conexinas, em tecido ósseo normal e neoplásico de cães
Increasing evidence indicates that junctional communiction by gap juctions has a critical role in a bone physiology. The main connexin (Cx) express involved in development, differentiation and regulation of tissue growth, is the called Cx43. However, other, two connexis are expressed: Cx45 and Cx46. Cx46 is retained as monomers in a trans-golgi compartment o
Publicado em: 2008
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16. Mecanismos de transdução de sinal envolvidos com a diferenciação de osteoblastos e osteocitos / Signal transduction activated during differentiation of osteoblsts and osteocytes
The main goal of this work was to investigate the signal transduction pathways triggered during the bone cells differentiation. In this way, several molecular aspects of this process were analyzed. Src kinase modulation by the low molecular weight protein tyrosine phosphatase (LMWPTP) was essential for the occurrence of the differentiation induced by ascorbi
Publicado em: 2008
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17. Estudo molecular de genes envolvidos em disturbios de queratinização e perda auditiva / Molecualr study in keratinization disturb and hearing loss genes
Nos organismos superiores, a comunicação entre as células ocorre através de proteínas denominadas conexinas, implicadas na comunicação intercelular (gap junction), as quais permitem a transferência direta de pequenas moléculas e íons. Na pele desempenham um papel crucial na sinalização e diferenciação epidérmica. Na cóclea as gap junctions ex
Publicado em: 2008
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18. Sobre os efeitos quimiopreventivos e antitumorais do guaraná, Paullinia cupana Mart var. sorbilis, em modelos experimentais in vivo e in vitro / On the chemopreventive and antineoplastic effects of guarana, Paullinia cupana Mart var. sorbilis, in in vivo and in vitro experimental models
O câncer é a segunda maior causa de morte no Brasil, atrás apenas de doenças cardíacas. Por isto, é evidente que grandes recursos sejam direcionados para a pesquisa no descobrimento de novas opções com a finalidade de erradicar esta doença. Dentre estas opções, a quimioprevenção do câncer tem chamado a atenção já que, mesmo com os imensos av
Publicado em: 2008
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19. Remodeling of dystrophin-glycoprotein complex, intercalated disk proteins, and contractile proteins in the hearts of mice subjected to sepsis induced by cecal ligation and puncture. / Remodelamento do complexo de glicoproteínas associadas à distrofina, do disco intercalar e das proteínas contráteis no coração de camundongos submetidos à sépsis induzida por ligação e perfuração do ceco
Sepsis and septic shock represent a complex syndrome of systemic inflammatory response, with multiple physiological and immunological abnormalities, commonly caused by bacterial infection. The most important consequence of the response is the involvement of many organs and tissues. Cardiac dysfunction, caused by impairment in myocardial contractility, has be
Publicado em: 2008
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20. Connexins in the early development of the African clawed frog Xenopus laevis (Amphibia): The role of the connexin43 carboxyl terminal tail in the establishment of the dorso-ventral axis
Connexins are a family of related proteins identified in vertebrate forming gap junctions, which mediate cell-to-cell communication in early embryos, with an important role in establishing embryonic asymmetry and ‘communication compartments’. By in situ hybridization, immunocytochemistry, reverse transcriptase PCR (RT-PCR) and western blotting we show th
Genetics and Molecular Biology. Publicado em: 2007-03
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21. O MODELO DESMIELINIZANTE DO BROMETO DE ETÍDIO (BE): ESTUDOS MORFOLÓGICOS EM CAMUNDONGOS C57BL/6 NORMAIS E KNOCKOUT PARA CONEXINA 32 / ETHIDIUM BROMIDE (EB) DEMYELINATING MODEL: MORPHOLOGIC STUDIES IN C57BL/6 NORMAL AND CX 32 KNOCKOUT MICE
Light and ultraestructural changes of central and peripheral nervous system lesions in mice KO for connexin-32 and submitted to the ethidium bromide gliotoxic demyelinating model are described. Their KO condition was tested with PCR and a negative connexin-32 labelling was performed by immunofluorescence. The experimental animals were C57BL/6 normal mice and
Publicado em: 2007
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22. Mechanisms of arrhythmogenesis in cardiomyocytes and development of in vitro model of cardiac hypertrophy and fibrosis induced by Trypanosoma cruzi / Mecanismos envolvidos na arritmogenese em cardiomiocitos e desenvolvimento de modelo in vitro de fibrose e hipertrofia cardiaca induzidos por Trypanosoma cruzi
Infection with protozoan Trypanosoma cruzi causes Chagas disease that among its manifestations presents a severe cardiac form, which can induce arrhythmias and sudden death. In the first part of this work we studied the effect of T. cruzi infection on host cell coupling and calcium homeostasis in monolayered cardiac myocytes. In moments of invasion of the pa
Publicado em: 2007
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23. Schistosomal granuloma as a system adaptive complex. Application of fractal dimension in characterization of their geometric properties. / Granuloma esquistossomótico como um sistema adaptativo complexo. Aplicação da dimensão fractal na caracterização de suas propriedades geométricas.
Schistosomal granuloma AS A COMPLEX ADAPTIVE SYSTEM: APPLICATION OF FRACTAL DIMENSION IN THE CHARACTERIZATION OF PROPERTIES GEOMETRIC. Waldemiro de Souza Romagna. [Introduction]. The schistosomal granuloma is a compact, organized collection of migrating cells, which along with cells of the affected organ, arrange themselves in the midst of extracellular matr
Publicado em: 2007
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24. Four whole-istic aspects of schistosome granuloma biology: fractal arrangement, internal regulation, autopoietic component and closure
This paper centers on some whole-istic organizational and functional aspects of hepatic Schistosoma mansoni granuloma, which is an extremely complex system. First, it structurally develops a collagenic topology, originated bidirectionally from an inward and outward assembly of growth units. Inward growth appears to be originated from myofibroblasts derived f
Memórias do Instituto Oswaldo Cruz. Publicado em: 2006-10