Connexin 43
Mostrando 25-36 de 133 artigos, teses e dissertações.
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25. Influence of connexin 43 expression in biliaries ducts hyperplasia, after biliary common duct obstruction (coledoco) model in mice with deletion of one allele of the connexin / Influência da expressão da conexina 43 em modelo de hiperplasia de ductos biliares, após a ligação do ducto biliar comum (colédoco), em camundongos com deleção em um dos alelos para o gene da conexina 43
Atualmente, as pesquisas sobre a as células epiteliais biliares expressam uma grande quantidade de conexina 43. O presente estudo avaliou influência do genótipo de camundongos Cx 43 +/- ou Cx 43 +/+, sobre a hiperplasia de ductos biliares, após a ligação do ducto biliar comum (colédoco). Neste estudo, foram utilizados seis grupos de camundongos BALB/c
Publicado em: 2006
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26. Estudo retrospectivo-sistemático e análise quantitativa da proliferação celular e apoptose; identificação da proteína conexina 43 e 26 aberrante em glândula perianal normal, hiperplásica e neoplásica em cães / Retrospective - systematic study and quantitative analysis of the cellular proliferation and apoptosis and identification of connexin 43 and aberrant 26 protein in normal, hyperplasic and neoplastic perianal glands in dogs
Two hundred and forty five neoplasms of the perianal glands of dogs from the archives of the Department of Pathology of the FMVZ/USP, 1984 to 2004, have been reviewed hystologically. Most of the cases (34%) were classified as moderately differentiated adenomas, group II, in males over 8 years of age, which showed an androgenic dependence of these neoplasms.
Publicado em: 2006
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27. Avaliação do papel da conexina 43 na angiogênese, experimentalmente induzida em córnea de camundongos / Evaluation the role of connexin 43 during angiogenesis, experimentally induced in mice córnea
The GAP junctions are intercellular streams responsible for the communication between close cells, which allow small molecules and ions to pass through them maintaining the cellular homeostasis. The GAP junction is formed of six proteins, the connexin. In the endothelial cell, there are the connexin 37, 40 and 43. In this study, we stimulated the angiogenesi
Publicado em: 2005
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28. Avaliação do papel da conexina 43 no desenvolvimento do granuloma, experimentalmente induzido em camundongos / Evaluation of the role of connexin 43 in the development of granuloma, experimentally induced in mice
A doença granulomatosa inflamatória envolve interações coordenadas entre linfócitos, monócitos/macrófagos, células epitelióides, eosinófilos, neutrófilos e fibroblastos. A comunicação intercelular mediada por junções gap, constituídas por conexinas, é responsável pela homeostase tecidual. A Cx43 está presente em células linfóides, célul
Publicado em: 2005
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29. Carcinogênese pulmonar em camundongos portadores de deleção em um dos alelos do gene da Cx43 / Lung carcinogenesis in mice with a deletion in one allele of Cx43 gene
Gap junctions are communicating protein channels formed between adjacent cells that allow the exchange of molecules and ions smaller than 1kDa; connexins are proteins that form these junctions. Studies in the literature have been showing the lower level of cell communication capacity and alterations in the expression and/or localization of connexins in neopl
Publicado em: 2005
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30. Análise da expressão diferencial de genes do folículo ovariano de fêmeas pré-púberes e púberes Bos primigenius indicus (Nelore) por meio da Análise Serial de Expressão Gênica (SAGE) / Analysis of differential gene expression of ovarian follicle from prepubertal and pubertal Bos primigenius indicus (Nelore) females by Serial Analysis of Gene Expression (SAGE)
Puberty is the stage where any mammal, male or female, becomes able to produce viable gametes and manifest complete sexual behavior. These are results from the gradative adjustment between the increase in gonadotrophic activity and the ability of gonads in undergoing simultaneously both steroidogenesis and gametogenesis. One of the major factors interferring
Publicado em: 2005
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31. Rastreamento de mutações nos genes PITX2, FOXC1 e GJA1 em pacientes com sindrome de Axenfeld-Rieger associada a glaucoma
Axenfeld-Rieger Syndrome (ARS) is arare disorder, usually transmitted in an autosomal dominant pattem characterized by anterior segment dysgenesis and often associated with developmental glaucoma. In addition to the ocular changes observed in ARS, syndromic features can also occur, such as facial bone defects, teeth anomalies and peri-umbilical skin involuti
Publicado em: 2005
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32. Expression and distribution of Connexin-43 in bovine trophoblast giant cells in three gestational phases / Expressão e distribuição da conexina 43 nas células trofoblásticas gigantes bovinas em três fases gestacionais
O presente trabalho estudou a expressão da conexina 43 nas células trofoblásticas gigantes bovinas, em especial nas células trofoblásticas gigantes binucleadas. Foram utilizadas 12 amostras de placenta bovina, divididas em três grupos segundo a fase gestacional, primeiro terço, segundo terço e terceiro terço da gestação. O tecido placentário foi
Publicado em: 2004
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33. Modulation of intercellular communication by differential regulation and heteromeric mixing of co-expressed connexins
Intercellular communication may be regulated by the differential expression of subunit gap junction proteins (connexins) which form channels with differing gating and permeability properties. Endothelial cells express three different connexins (connexin37, connexin40, and connexin43) in vivo. To study the differential regulation of expression and synthesis o
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04
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34. Identification of a protein kinase activity that phosphorylates connexin43 in a pH-dependent manner
The carboxyl-terminal (CT) domain of connexin43 (Cx43) has been implicated in both hormonal and pH-dependent gating of the gap junction channel. An in vitro assay was utilized to determine whether the acidification of cell extracts results in the activation of a protein kinase that can phosphorylate the CT domain. A glutathione S-transferase (GST)-fusion pro
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04
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35. Chronic hypertension alters the expression of Cx43 in cardiovascular muscle cells
Connexin43 (Cx43), the predominant gap junction protein of muscle cells in vessels and heart, is involved in the control of cell-to-cell communication and is thought to modulate the contractility of the vascular wall and the electrical coupling of cardiac myocytes. We have investigated the effects of arterial hypertension on the expression of Cx43 in aorta a
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04
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36. Gap junctions in isolated rat aorta: evidence for contractile responses that exhibit a differential dependence on intercellular communication
Connexin43 (Cx43) is a major gap junction protein present in the Fischer-344 rat aorta. Previous studies have identified conditions under which selective disruption of intercellular communication with heptanol caused a significant, readily reversible and time-dependent diminution in the magnitude of a1-adrenergic contractions in is
Brazilian Journal of Medical and Biological Research. Publicado em: 2000-04