Connexin 43
Mostrando 1-12 de 133 artigos, teses e dissertações.
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1. The liver injury following ischemia and reperfusion is worse in experimental knockout heterozygote mouse model for expression of connexin 43
Abstract Purpose: To evaluate that Connexin (Cx43) plays a role in lesions after hepatic ischemia/reperfusion (IR) injury. Methods: We use Cx43 deficient model (heterozygotes mice) and compared to a wild group. The groups underwent 1 hour ischemia and 24 hours reperfusion. The heterozygote genotype was confirmed by PCR. We analyzed the hepatic enzymes (AST
Acta Cir. Bras.. Publicado em: 13/12/2019
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2. DACT1 Involvement in the Cytoskeletal Arrangement of Cardiomyocytes in Atrial Fibrillation by Regulating Cx43
Abstract Objective: To determine the role of the dishevelled binding antagonist of beta catenin 1 (DACT1) in the cytoskeletal arrangement of cardiomyocytes in atrial fibrillation (AF). Methods: The DACT1 expression and its associations with the degree of fibrosis and β-catenin in valvular disease patients were analyzed by immunohistochemistry and Masson�
Braz. J. Cardiovasc. Surg.. Publicado em: 23/09/2019
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3. Severity of chronic experimental Chagas' heart disease parallels tumour necrosis factor and nitric oxide levels in the serum: models of mild and severe disease
Heart tissue inflammation, progressive fibrosis and electrocardiographic alterations occur in approximately 30% of patients infected by Trypanosoma cruzi, 10-30 years after infection. Further, plasma levels of tumour necrosis factor (TNF) and nitric oxide (NO) are associated with the degree of heart dysfunction in chronic chagasic cardiomyopathy (CCC). Thus,
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-06
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4. Retinoic acid and cAMP inhibit rat hepatocellular carcinoma cell proliferation and enhance cell differentiation
Hepatocellular carcinoma (HCC) is the third highest cause of cancer death worldwide. In general, the disease is diagnosed at an advanced stage when potentially curative therapies are no longer feasible. For this reason, it is very important to develop new therapeutic approaches. Retinoic acid (RA) is a natural derivative of vitamin A that regulates important
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-08
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5. Efeitos da rosuvastatina e da atividade física de baixa intensidade na morfologia renal de ratos normotensos e espontaneamente hipertensos (SHR) / Effects of the rosuvastatin and low intensity physical activity on the morphology of kidney from normotensive and spontaneously hypertensive rats (SHR)
Desordens do sistema renal podem ser as causas da hipertensão arterial, a qual pode, por sua vez, causar doenças renais. A pressão sanguínea elevada é muito comum também nas doenças crônicas dos rins, e é, além disso, um conhecido fator de risco para uma mais rápida progressão da falha renal. A incidência de doenças renais crônicas está aumen
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/09/2011
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6. Avaliação da expressão e localização da conexina 43 na injúria isquêmica renal aguda / Evaluation of Connexin 43 expression and localization in renal acute ischemic injury
The cells require contact with other cells and the extracellular matrix for tissue formation. Gap junctions are narrow channels connecting the cytoplasm of two adjacent cells, promoting the passage of inorganic ions, amino acids, nucleotides and other metabolites. These junctions are composed of two conexons or hemichannels, crossing the cell plasma membrane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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7. Efeitos benéficos da rosuvastatina na estrutura renal de ratos espontaneamente hipertensos (SHR) / Rosuvastatin beneficially alters the glomerular structure of kidneys from spontaneously hypertensive rats (SHRs)
A incidência de doenças renais crônicas está aumentando no mundo, e há uma grande necessidade de identificar as terapias capazes de deter ou reduzir a progressão da doença. Há crescente evidência clínica e experimental de que as estatinas poderiam desempenhar um papel terapêutico. Recentes estudos clínicos e experimentais têm mostrado que as est
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/04/2011
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8. Low-Intensity physical activity beneficially alters the ultrastructural renal morphology of spontaneously hypertensive rats
INTRODUCTION AND OBJECTIVE: Kidney disorders can cause essential hypertension, which can subsequently cause renal disease. High blood pressure is also common among those with chronic kidney disease; moreover, it is a well-known risk factor for a more rapid progression to kidney failure. Because hypertension and kidney function are closely linked, the present
Clinics. Publicado em: 2011
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9. Gap junction reduction in cardiomyocytes following transforming growth factor-β treatment and Trypanosoma cruzi infection
Gap junction connexin-43 (Cx43) molecules are responsible for electrical impulse conduction in the heart and are affected by transforming growth factor-β (TGF-β). This cytokine increases during Trypanosoma cruzi infection, modulating fibrosis and the parasite cell cycle. We studied Cx43 expression in cardiomyocytes exposed or not to TGF-β T. cruzi, or SB-
Memórias do Instituto Oswaldo Cruz. Publicado em: 2009-12
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10. Evaluation of connexin 43 expression in the miocardium in health dogs submited or not to a cardiopulmonary baypass / Avaliação da expressão da conexina 43 no miocárdio de cães indenes submetidos ou não à técnica de circulação extracorpórea
Cardiopulmonary bypass (CPB) replaces the heart and lung function during the main period of cardiac surgery, and it allows the access of the surgeon inside the organ for a long time, ensuring tissue oxygenation and the elimination of end products. However, this procedure isn´t used as a routine in veterinary medicine because of the high costs, and besides i
Publicado em: 2009
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11. Efeitos da deleção do gene Cx43 sobre o desenvolvimento fetal de camundongos de diferentes backgrounds genéticos: ênfase na osteogênese / Effects of Cx43 gene deletion on mouse fetal development in different genetics backgrounds: Emphasis in osteogenesis
Conexinas são proteínas que compõem as junções comunicantes do tipo gap, e a diminuição na sua expressão tem sido relacionada com diversas alterações fisiológicas, entre elas algumas síndromes, malformações genéticas, o aumento da proliferação celular e a carcinogênese. Dentre as isoformas das conexinas presentes nos tecidos animais, a Cx43
Publicado em: 2009
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12. Modulação da expressão de conexinas na retina: um estudo morfológico, bioquímico e funcional. / Modulation of connexin expression in retina: a study using morphological, biochemical and functional approaches.
Life is a dynamic process in time and space, resulting from an interaction provided by gap junctions (GJs), channels composed of connexins (Cxs) that permits the passage of molecules up to 1kDa and ions. The aim of this study was analyze the modulation of Cxs during development, dark adaptation and after local mechanical trauma in the retina using techniques
Publicado em: 2009