Connective Tissue Remodeling
Mostrando 1-12 de 36 artigos, teses e dissertações.
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1. The E3 ligase MuRF2 plays a key role in the functional capacity of skeletal muscle fibroblasts
Fibroblasts are a highly heterogeneous population of cells, being found in a large number of different tissues. These cells produce the extracellular matrix, which is essential to preserve structural integrity of connective tissues. Fibroblasts are frequently engaged in migration and remodeling, exerting traction forces in the extracellular matrix, which is
Braz J Med Biol Res. Publicado em: 29/08/2019
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2. Cicatrização: uso de matriz de colágeno
Resumo A matriz de colágeno Ologen TM é um novo agente antifibrótico composto por uma matriz porosa de atelocolageno tipo I e glicosaminoglicanos reticulados, que pode ser utilizado como uma alternativa para a modulação da cicatrização nas cirurgias. Por ser altamente poroso e biodegradável, este implante auxilia nos processos de reparação fisioló
Rev. bras.oftalmol.. Publicado em: 12/08/2019
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3. Cassava biopolymer polyamide hydrogel accelerates healing of induced skin woundsin rats
RESUMO O objetivo deste estudo foi avaliar macro e microscopicamente a cicatrização de feridas cutâneas induzidas em ratos, a partir da aplicação tópica do hidrogel de biopolímero de poliamido de mandioca. Trinta e dois ratos foram divididos em quatro grupos (n= 8): controle negativo, tratado com solução salina; controle positivo, com pomada comerci
Arq. Bras. Med. Vet. Zootec.. Publicado em: 14/06/2019
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4. MicroRNAs and Current Concepts on the Pathogenesis of Abdominal Aortic Aneurysm
Abstract Objective: Abdominal aortic aneurysm is an important cause of morbidity and mortality in the elderly. Currently, the only way to prevent rupture and death related to abdominal aortic aneurysms is through surgical intervention. Endovascular treatment is associated with less morbidity than conventional treatment. The formation of an aneurysm is a comp
Braz. J. Cardiovasc. Surg.. Publicado em: 2017-06
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5. Roles of the ERK1/2 and PI3K/PKB signaling pathways in regulating the expression of extracellular matrix genes in rat pulmonary artery smooth muscle cells
Abstract Purpose: To investigate the mechanisms by which PD98059 and LY294002 interfere with the abnormal deposition of extracellular matrix regulated by connective tissue growth factor (CTGF) of rat pulmonary artery smooth muscle cells (PASMCs). Methods: Rat PASMCs were cultured and separated into a control group. Real-time fluorescence quantitative PCR w
Acta Cir. Bras.. Publicado em: 2017-05
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6. Increased immunohistochemical expression of YKL-40 in the spleen of patients with portal hypertension
YKL-40 has been identified as a growth factor in connective tissue cells and also a migration factor in vascular smooth muscle cells. To a large extent, the increase of serum YKL-40 is attributed to liver fibrosis and asthma. However, the relationship of the expression and clinical/prognostic significance of YKL-40 to the splenomegaly of patients with portal
Brazilian Journal of Medical and Biological Research. Publicado em: 2012-03
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7. CCN2/CTGF silencing blocks cell aggregation in embryonal carcinoma P19 cell
Connective tissue growth factor (CCN2/CTGF) is a matricellular-secreted protein involved in extracellular matrix remodeling. The P19 cell line is an embryonic carcinoma line widely used as a cellular model for differentiation and migration studies. In the present study, we employed an exogenous source of CCN2 and small interference RNA to address the role of
Braz J Med Biol Res. Publicado em: 2011-03
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8. Interação do alendronato e da vitamina K no metabolismo osteomineral de ratas ovariectomizadas
The bone is a specialized form of connective tissue that provides support for metabolic and biomechanical throughout the body. Thus, the bone is very dynamic, with constantly renewing itself. His integrity therefore depends on the balance between the processes of formation and resorption. The loss of this balance alters both the structure of organic matrix a
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 29/07/2010
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9. Efeitos da ovariectomia e treinamento resistido na atividade da metaloproteinase-2 no tendão calcâneo de ratas
Tendons remodeling relies upon extracellular matrix restructuring by the matrix metalloproteinases (MMPs). The aim of this study was to investigate MMP-2 activity in different regions of the calcanear tendon after resistance training in ovariectomized rats. Wistar adult female rats were grouped into: sedentary (Sed-Intact); ovariectomized sedentary (Sed-Ovx)
Publicado em: 2010
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10. Structural and ontogenetic study of urachus and urinary bladder in normal and anencephaly human fetuses in second gestatinal trimester / Estudo estrutural e ontogenético do úraco e da bexiga de fetos humanos normais e com anencefalia no segundo trimestre gestacional
The objective of this work is to present an ontogenetic and structural study of the urachus in normal human fetuses and of the bladder in normal and anencephalic fetuses during the second gestational trimester. Fifty nine fetuses were used, 47 normal (22 male and 25 female) and 12 anencephalic (5 male and 7 female) with ages between 13 and 23 weeks post conc
Publicado em: 2010
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11. Alloxan-induced diabetes delays repair in a rat model of closed tibial fracture
A closed fracture was performed on the left tibia of 3-month-old Wistar rats weighing 250 to 350 g that were either healthy (N = 24) or made diabetic with alloxan (N = 24) to investigate the effect of alloxan-induced diabetes on the course of bone fracture healing. Histomorphometric analysis of the fracture site was performed at 7, 14, 25, and 35 days. After
Brazilian Journal of Medical and Biological Research. Publicado em: 30/04/2008
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12. Detection of metalloproteinases of the gelatinases family and their inhibitors in the interpubic ligament of the mouse, during pregnancy / Detecção de metaloproteinases da familia das gelatinases e de seus inibidores no ligamento interpubico do camundongo, durante a prenhez
During pregnancy of some rodents a deep remodeling occurs in the pubic symphysis (PS). In the mouse, these fibrocartilagenousarticulation are gradually replaced by a dense connective tissue, forming the interpubic ligament (IL) at the end of pregnancy. Right after birth, this ligament is rapidly remodeled and the space between the two bones is quickly closed
Publicado em: 2007