Efeitos da ovariectomia e treinamento resistido na atividade da metaloproteinase-2 no tendão calcâneo de ratas

AUTOR(ES)

Guilherme Borges Pereira

DATA DE PUBLICAÇÃO

2010

RESUMO

Tendons remodeling relies upon extracellular matrix restructuring by the matrix metalloproteinases (MMPs). The aim of this study was to investigate MMP-2 activity in different regions of the calcanear tendon after resistance training in ovariectomized rats. Wistar adult female rats were grouped into: sedentary (Sed-Intact); ovariectomized sedentary (Sed-Ovx); acute exercise (AcuteEx-Intact); ovariectomized acute exercise (AcuteEx-Ovx); resistance trained (ChronicEx-Intact) and ovariectomized resistance trained (ChronicEx-Ovx) (n= 10 each group). The resistance training protocol required the animals to climb a 1.1-m vertical ladder with weights attached to their tail was used. The sessions were performed once every 3 days with 4-9 climbs and 8-12 dynamic movements per scaling. The acute groups performed one session, and the chronic groups underwent a 12-week of resistance training. There was an increase in total MMP-2 activity in Sed- Ovx, AcuteEx-intact and ChronicExintact compared with Sed-Intact in the proximal region of calcanear tendon. AcuteEx-Ovx exhibited higher total MMP-2 than Sed-Ovx and AcuteEx-Intact in the distal region of calcanear tendon. Chronic-Ovx presented lower total MMP-2 activity than Sed-Ovx and Chronic-Intact in the distal region of tendon. The active MMP-2 was higher for the AcuteEx- Ovx than Sed-Ovx and AcuteEx-Intact in proximal region of tendon. There was higher active MMP-2 in the distal region of tendon in the Acute-Ovx than Sed-Ovx and AcuteEx-Intact. Ovariectomy and resistance exercise modulate MMP-2 activity according to specific tendon region, indicating a differentiated tissue remodeling.

ASSUNTO(S)

hormônios ovarianos metalopeptidases de matrizes menopausa connective tissue remodeling matrix metallopeptidases tecido conjuntivo ovariectomia remodelamento do tecido conjuntivo ovarian hormones fisiologia exercício resistido tendão calcanear calcanear tendon exercise

Documentos Relacionados

• Efeitos da ovariectomia e treinamento de força na concentração tecidual de dopamina e serotonina na via nigroestriatal e mesolímbica de ratas
• A Redução do Colágeno Tipo I está Associada ao Aumento da Atividade da Metaloproteinase-2 e da Expressão Proteica de Leptina no Miocárdio de Ratos Obesos
• Efeitos do treinamento resistido sobre a expressão gênica de moléculas envolvidas na oxidação de gordura e na lipogênese no fígado de ratas ovariectomizadas
• Efeitos do treinamento de força sobre a densidade mineral óssea (DMO): (1) estudo da biomecânica óssea e da atividade da metaloproteinase -2 (MMP-2) em ratas ovariectomizadas; (2) estudo de biomarcadores inflamatórios e do remodelamento ósseo em mulheres pósmenopáusicas
• Xantoma no tendão calcâneo