Conformational Changes
Mostrando 13-24 de 1400 artigos, teses e dissertações.
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13. Avaliação da expressão e localização da conexina 43 na injúria isquêmica renal aguda / Evaluation of Connexin 43 expression and localization in renal acute ischemic injury
The cells require contact with other cells and the extracellular matrix for tissue formation. Gap junctions are narrow channels connecting the cytoplasm of two adjacent cells, promoting the passage of inorganic ions, amino acids, nucleotides and other metabolites. These junctions are composed of two conexons or hemichannels, crossing the cell plasma membrane
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 20/06/2011
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14. Estudos da dinâmica estrutural da proteína ligante de cálcio S100A12 humana e da lisozima T4 / Structural dynamics studies of human calcium binding protein S100A12 and T4 lysozyme
The work presented here was conceived with two main objectives. The first one, more general, involved the implementation of a new methodology for the study of conformational changes in proteins, i.e., its structural dynamics. The technique of Site-directed Spin Labeling combined with Electronic Paramagnetic Resonance (SDSL-EPR) are the pillars of this new me
Publicado em: 2011
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15. Espectroscopia Raman em Cristais de L-Valina Deuterada e L-Isoleucina sob Altas PressÃes / Raman Spectroscopy in Crystals Deuterated L-valine and L-isoleucine in High Pressures
In this thesis, are studied by Raman spectroscopy of two amino acid crystals subjected to conditions of high pressures. The first is a sample of deuterated L-Valine. Initially, an attempt was made to identify all the bands that appear in the Raman spectrum of deuterated L-Valine, comparing with the results of L-Valine hydrogenated in the litera- ture. The fo
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 24/09/2010
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16. Análises moleculares das vias de sinalização de morte celular originadas no retículo endoplasmático / Molecular analyses of cell death pathways signalling originated in the endoplasmic reticulum
Abiotic and biotic stresses are responsible for major losses in agricultural productivity world wise. Therefore, the understanding of mechanisms of plant stress response and adaptation to such conditions should provide the foundation for engineering plant stress tolerance and hence maximizing the yield of crops growing under adverse environmental conditions.
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 11/02/2010
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17. Environmentally responsive polymeric "intelligent" materials: the ideal components of non-mechanical valves that control flow in microfluidic systems
Miniaturization and commercialization of integrated microfluidic systems has had great success with the development of a wide variety of techniques in microfabrication, since they allowed their construction at a low cost and by following simple step-series procedures. However, one of the major challenges in the design of microfluidic systems is to achieve co
Brazilian Journal of Chemical Engineering. Publicado em: 2010-03
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18. Resolução da estrutura tridimensional do inibidor tríptico e quimotrípico de Vigna unguiculata em complexos binário e ternário
The inhibitor BTCI (Black-eyed Pea Trypsin and Chymotrypsin Inhibitor) was purified from Vigna unguiculata seeds and crystallized in binary complex with -trypsin and in ternary complex with - chymotrypsin and -trypsin at pH 4.5 and 7.5. The crystallographic data were collected at the National Synchrotron Light Laboratory (LNLS). The c
Publicado em: 2010
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19. Interação da proteína albumina do soro bovino (BSA) com substratos sintéticos / Interaction of the protein bovine serum albumin (BSA) with synthetic substrates.
The interface formed by biological materials and synthetic materials has great importance in biomedical applications such as the development of biomaterials for medical implants, which has as an essential process of protein adsorption on the surface of biomaterials, and is not yet well understood in the molecular level. Some proteins undergo conformational c
Publicado em: 2010
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20. Estudo de materiais, estruturas de dispositivos e fenômenos de transporte em sistemas fotovoltaicos híbridos orgânico-inorgânico / Study of materials, device structures and transport phenomena in hybrid photovoltaic systems
Recently a fast development in organic and hybrid photovoltaic field has been observed. Such devices are fabricated by organic semiconductors within components of a heterojunction, in which bulk heterojunctions obtained via interpenetrating networks at the sub-20-nm length scale. It permits the effective collection of photogenerated charge carriers even with
Publicado em: 2010
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21. Estudos estruturais de histatina-5 e seu análogo, TOAC0-histatina-5: interação com metais e sistemas biomiméticos / Structural studies of Histatin-5 and its analogue, TOAC0-Histatin-5: interaction with metals and biomimetic systems
The mechanism of action of histatin-5 (Hst-5), an antifungal antimicrobial peptide from human saliva is not completely clarified. Circular dichroism (CD), fluorescence, and electron paramagnetic resonance (EPR) were used to examine the conformational behavior of Hst-5 and its analogue containing the paramagnetic amino acid TOAC at the N-terminus (TOAC0-Hst-5
Publicado em: 2008
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22. Propriedades termodinâmicas da Prolil Oligopeptidase de Trypanosoma brucei
Trypanosoma brucei secrets a prolyl oligopeptidase (POPTb) which is possibly involved in the pathogenesis of sleeping sickness. It is able to hydrolyze prolinecontaining peptide hormones and is therefore considered a good target for the development of drugs to treat the disease. As the crystal structure of POPTb has not been solved yet, we used circular dich
Publicado em: 2008
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23. A mechanistic view of mitochondrial death decision pores
Mitochondria increase their outer and inner membrane permeability to solutes, protons and metabolites in response to a variety of extrinsic and intrinsic signaling events. The maintenance of cellular and intraorganelle ionic homeostasis, particularly for Ca2+, can determine cell survival or death. Mitochondrial death decision is centered on two processes: in
Brazilian Journal of Medical and Biological Research. Publicado em: 12/04/2007
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24. Study of conformational changes of macromolecules in solutions using X-ray scattering / Estudo de mudanças conformacionais de macromoleculas em solução usando espalhamento de raio-X
During the last decades, the study of conformational changes in biological macromolecules has been a great challenge for the scientists, and continues to be an important subject of biotechnological interest and protein engineering. The process of folding (unfolding) of protein molecules has been intensively studied, because this investigation can contribute
Publicado em: 2007