Computational Biology
Mostrando 1-12 de 110 artigos, teses e dissertações.
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1. RM1 Semiempirical Model: Chemistry, Pharmaceutical Research, Molecular Biology and Materials Science
In this review, we show improvements to the semiempirical quantum chemical method RM1 and present a wide range of its applications as reported by researchers of various areas, such as theoretical, organic, physical, analytical, and inorganic chemistry, as well as their interfaces with medicinal chemistry, biology, and materials science. Success of RM1 is see
J. Braz. Chem. Soc.. Publicado em: 2019-04
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2. From Medicinal Chemistry to Human Health: Current Approaches to Drug Discovery for Cancer and Neglected Tropical Diseases
ABSTRACT Scientific and technological breakthroughs have compelled the current players in drug discovery to increasingly incorporate knowledge-based approaches. This evolving paradigm, which has its roots attached to the recent advances in medicinal chemistry, molecular and structural biology, has unprecedentedly demanded the development of up-to-date comput
An. Acad. Bras. Ciênc.. Publicado em: 15/02/2018
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3. Metabolomics in the fight against malaria
Metabolomics uses high-resolution mass spectrometry to provide a chemical fingerprint of thousands of metabolites present in cells, tissues or body fluids. Such metabolic phenotyping has been successfully used to study various biologic processes and disease states. High-resolution metabolomics can shed new light on the intricacies of host-parasite interactio
Mem. Inst. Oswaldo Cruz. Publicado em: 2014-08
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4. DNA for nano-bio scale computation of chemical formalisms using Higher Order Logic (HOL) and analysis using an interdisciplinary approach
Bio-molecular computing, 'computations performed by bio-molecules', is already challenging traditional approaches to computation both theoretically and technologically. Often placed within the wider context of ´bio-inspired' or 'natural' or even 'unconventional' computing, the study of natural and artificial molecular computations is adding to our understan
Mat. Res.. Publicado em: 04/07/2014
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5. A proposal towards resilient complex networks through evaluation and adaptation mechanisms
Attacks and failures tolerance of complex networks is related to the concept of vulnerability in different contexts, from biology and sociology to computer science and physics. Studies have revealed that the topologies of these networks are inherently vulnerable to failures of central elements. Complex adaptive systems, emergent in nature, are considered mor
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 12/03/2012
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6. Genoma comparison problems / Problemas de comparação de genomas
Esta tese aborda três aspectos da comparação entre genomas: primeiro, eventos de transposição; segundo, eventos de reversão e de reversão quase-simétrica; terceiro, estudo da distância entre genomas sem ligação com algum tipo específico de rearranjo. O estudo do primeiro aspecto, eventos de transposição, permitiu a criação de um novo algoritm
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 08/02/2012
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7. Desenvolvimento de um algoritmo para identificação e caracterização de cavidades em regiões específicas de estruturas tridimensionais de proteínas / Development of an algorithm to identify and characterize cavities in specific regions of three-dimensional structures of proteins.
The identification and characterization of geometrical and physical-chemical properties in protein vacant spaces aggregates important information for steering rational drug designing and functional characterization of binding and catalytic sites. Therefore, several softwares have been develop during the past two decades in order to perform such characterizat
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 25/05/2011
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8. Busca multimodal para apoio à pesquisa em biodiversidade / Multimodal search to support research on biodiversity
Research on Computing applied to biodiversity present several challenges, ranging from the massive volumes of highly heterogeneous data to the variety in user profiles. This kind of scenario requires versatile data retrieval and management tools. Available tools are still limited. Most often, they only consider textual data and do not take advantage of the m
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 13/04/2011
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9. A pipeline to study structural interactions among Spodoptera frugiperda serine proteinases and plant proteinase inhibitors.
We propose here a computational biology pipeline to identify and analyze possible structural determinants that could explain some level of insensitivity by S. frugiperda serine proteinases (SPs) against plant PIs observed in a real time PCR experiment.
CONGRESSO BRASILEIRO DE GENÉTICA. Publicado em: 2011
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10. A dymanical approach to study the immunocompetence and the immunological tolerance of mammals.
In this paper we present an in silico study about immune tolerance, where phase transitions have been observed when antigen dosages were varied in virtual samples. Using a dynamical model to study the behavior of the immune system - presented in a previous edition of the International Symposium on Mathematical and Computational Biology -, we have identified
ANNUAL MEETING OF THE SOCITY FOR MATHEMATICAL BIOLOGY; INTERNATIONAL SYMPOSIUM ON MATHEMATICAL AND COMPUTATIONAL BIOLOGY. Publicado em: 2011
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11. CNBi: the new Brazilian National Consortium for Bioinformatics.
PRESENTATION: The National Consortium for Bioinformatics (CNBi) is a multidisciplinary center dedicated to research, development, management and technical support on questions arising from bioinformatics. It was created by a joint effort between three laboratories from São Paulo state in Brazil: the Genomic and Expression Laboratory (UNICAMP), Applied Bioin
INTERNATIONAL CONFERENCE OF THE BRAZILIAN ASSOCIATION FOR BIOINFORMATICS AND COMPUTATIONAL BIOLOGY. Publicado em: 2011
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12. Identificação de genes por comparação de DNAs
O Problema da Identicação de Genes consiste na busca pelas regiões codicantes presentes em uma sequência de DNA. Uma das formas de abordar esse problema é através da comparação entre sequencias de DNA próximas evolutivamente. Neste trabalho realizamos um estudo detalhado do problema neste contexto comparativo, propondo uma formulação matemática p
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 15/12/2010