Complement C4d
Mostrando 13-24 de 259 artigos, teses e dissertações.
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13. Análise da detecção de C4d, linfócitos B e plasmócitos no processo de rejeição ao aloenxerto renal / Analysis of C4d, B lymphocytes and plasma cells detection in the renal allograft rejection
A rejeição ao aloenxerto mediada por mecanismos celulares ou humorais representa uma importante complicação no pós-transplante renal. Estudos anteriores demonstraram que o depósito de C4d peritubular é um marcador de rejeição mediada por anticorpos. A técnica padrão ouro para a pesquisa de C4d é a imunofluorescência em criostato. No entanto, o m
Publicado em: 2010
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14. Modulação de eventos da imunidade humoral e celular por venenos brutos e componentes dos venenos de Bothrops jararacussu e Bothrops pirajai / Modulation of events of humoral and cellular immunity by crude venom and components of Bothrops jararacussu and Bothrops pirajai
Snakes of the genus Bothrops are responsible for 90% of snakebites in Brazil. Their venoms cause local effects in humans and animals, such as hemorrhage, edema, pain and necrosis, characteristic of an inflammatory response. The mechanism is not well defined. These effects are related to the combined action of proteases, substances that induce bleeding and ph
Publicado em: 2010
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15. Influence of point variants of pattern recognition receptors in the susceptibility to human malaria / Influência de variantes de receptores de reconhecimento padrão na suscetibilidade à malária
Malaria is one of the major causes of disease and death worldwide, mainly of children. It is also the strongest known force for evolutionary selection in the recent history of the human genome. Besides environmental and parasite factors, host genetic factors play a major role in determining both susceptibility to malaria and the course of infection. Innate i
Publicado em: 2008
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16. Produção, caracterização funcional e imunogênica de uma proteína dermonecrótica recombinante 9recLiD1) da aranha Loxosceles intermédia
In the present study the recombinant form (rLiD1) of a dermonecrotic protein from the Brazilian Loxosceles intermedia spider venom was expressed in Escherichia coli and purified by reversed-phase HPLC. Twenty five mg of rLiD1 was produced from liter of bacterial culture. The molecular weight of rLiD1 was verified by mass spectrometry (32,758 Da). rLiD1 displ
Publicado em: 2008
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17. Ferrugem asiática da soja : resistência, controle químico e tolerância
The asian soybean rust (ASR) caused by Phakopsora pachyrhizi Syd. &P. Syd. is the most destructive leaf disease of this culture. The objective of this study was to assess forms of resistance to complement traditional qualitative resistance (vertical), through studies of quantitative resistance (horizontal) and tolerance, conditioned by minor genes, which may
Publicado em: 2008
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18. Genetic potential for an acute inflammatory response in IgA glomerulonephritis in mice
Mice selected on the basis of an acute inflammatory response (AIR) can provide information about the immunopathological mechanisms of glomerulonephritis. We studied the differences between mice selected for a maximal AIR (AIRmax that attract more polymorphonuclear cells to the site of injury) or a minimal AIR (AIRmin that attract more mononuclear cells) in a
Brazilian Journal of Medical and Biological Research. Publicado em: 2005-12
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19. Influencia de polimorfismos em genes de citocinas na morbidade da doença periodontal inflamatoria cronica
Chronic Periodontal Disease (CPD) is characterized by an inflammation in the supporting tissues of the teeth. It is primarily caused by bacteria present on tooth surfaces (biofilm), which adjacent to the gingiva, stimulate host cells to produce immunoinflammatory response. Cytokines represent important pathological mediators, which influence the onset and pr
Publicado em: 2002
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20. Quimiotaxia de polimorfonucleares em crianças gravemente enfermas
This study examined the in vitro chemotaxis of polymorphonuclear leukocytes (PMNs) obtained from critical care children admitted to a pediatric intensive care unit. The investigation was carried out in three stages. In the first, cells from eight patients and eight healthy volunteers were used to standardize the conditions for the chemotaxis assay. For this
Publicado em: 1996
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21. Correlation of the activation of the fourth component of complement (C4) with disease activity in systemic lupus erythematosus.
Levels of C4d, a fragment of C4 generated during activation of the classical complement pathway, were measured in the plasma of 48 patients with systemic lupus erythematosus, 11 with inactive (group 1), 23 with mildly active (group 2), 14 with moderately/severely active disease (group 3), and 30 healthy subjects. Levels of C3d, C4, and C3 were also measured
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22. Pneumococcal polysaccharides complexed with C3d bind to human B lymphocytes via complement receptor type 2.
The immunoregulatory function of the complement system has been the focus of many investigations. In particular, fragments of complement factor C3 have been shown to play a role in B-lymphocyte activation and proliferation, lymphokine production, and the generation of in vitro antibody production. Purified pneumococcal polysaccharides (PS) can induce direct
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23. Reflection of disease activity in rheumatoid arthritis by indices of activation of the classical complement pathway.
Levels of C4d, a fragment of C4 generated during activation of the classical complement pathway, were measured in the plasma of 77 patients with rheumatoid arthritis and 30 healthy subjects. Disease activity was judged according to Ritchie's articular index to be mildly active in 31 (group 1), moderately active in 29 (group 2), and severely active in 17 pati
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24. Increased concentration of C4d complement protein in CSF in amyotrophic lateral sclerosis.
Plasma and CSF concentrations of C4d and the circulating immune complex to C1q were measured in 27 patients with amyotrophic lateral sclerosis (ALS) or cervical spondylosis. There was no significant difference among groups in plasma C4d or in plasma or CSF concentrations of the circulating immune complex to C1q. The ALS group, however, had a significantly hi