Colonic Carcinogenesis
Mostrando 1-12 de 26 artigos, teses e dissertações.
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1. The Prognostic Roles of PYCR2 and ZBTB18 Expression in Tissues of Colorectal Carcinoma and Non-Neoplastic Tissues: An Immunohistochemical Study
Abstract Background It is important to detect novel biomarkers responsible for the progression and spread of colorectal cancer (CRC) to better evaluate the prognosis of the patients, provide better management, and foster the development of therapeutic targets. In humans, pyrroline-5-carboxylate reductase 2 (PYCR2) is encoded on chromosome 1q42.12, and its m
Journal of Coloproctology (Rio de Janeiro). Publicado em: 2022
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2. Ponderal behavior of rats fed an omegas 3, 6 and 9 enriched diet submitted to colon carcinogenesis induced by azoxymethane
PURPOSE: To assess weight changes in rats fed diets with different ratios of omegas 3, 6 and 9 submitted to colonic carcinogenesis induced by Azoxymethane (AOM). METHODS: Sixty rats with three weeks of life were distributed into five groups of specific diets containing 12 animals each: GI- Standard diet without adminstration of AOM, GII- Standard diet with a
Acta Cir. Bras.. Publicado em: 2013-10
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3. Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis
β-ionone (βI), a cyclic isoprenoid, and geraniol (GO), an acyclic monoterpene, represent a promising class of dietary chemopreventive agents against cancer, whose combination could result in synergistic anticarcinogenic effects. The chemopreventive activities of βI and GO were evaluated individually or in combination during colon carcinogenesis induced by
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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4. Fish oil ingestion reduces the number of aberrant crypt foci and adenoma in 1,2-dimethylhydrazine-induced colon cancer in rats
We determined the effect of fish oil (FO) ingestion on colonic carcinogenesis in rats. Male Wistar rats received 4 subcutaneous injections (40 mg/kg body weight each) of 1,2-dimethylhydrazine (DMH) at 3-day intervals and were fed a diet containing 18% by weight FO (N = 10) or soybean oil (SO, N = 10) for 36 weeks. At sacrifice, the colon was removed, aberran
Brazilian Journal of Medical and Biological Research. Publicado em: 2009-12
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5. Long-term aerobic swimming training by rats reduces the number of aberrant crypt foci in 1,2-dimethylhydrazine-induced colon cancer
We determined the effect of long-term aerobic swimming training regimens of different intensities on colonic carcinogenesis in rats. Male Wistar rats (11 weeks old) were given 4 subcutaneous injections (40 mg/kg body weight each) of 1,2-dimethyl-hydrazine (DMH, dissolved in 0.9% NaCl containing 1.5% EDTA, pH 6.5), at 3-day intervals and divided into three ex
Brazilian Journal of Medical and Biological Research. Publicado em: 2008-11
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6. Estudo da ação antineoplástica do ipê roxo na carcinogênege induzida pelo azoximetano em camundongos
The Purple Ipe (Tabebuia avellanedae), a tree of the Bignoniacea family found in Brazil, is known by the popular medicine as antitumoral agent against some neoplasias, between them the colorretal cancer. The objective of the present work is experimentally to study the antitumoral action of β- lapachone, that is an extracted constituent of purple ipe, in
Publicado em: 2007
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7. Trypanosoma cruzi infection and/or administration of the nonsteroidal anti-inflammatory nimesulide increase the number of colonic crypts overexpressing metallothioneins in rat colon carcinogenesis
Trypanosoma cruzi infection and nonsteroidal anti-inflammatory drugs inhibit colorectal carcinogenesis by mechanisms not completely known and metallothionein proteins (MTs) may be involved in this process. Sixty-six male Wistar rats weighing 90 to 120 g were randomly divided into seven groups (GI to GVII). GI, GII and GIII animals were subcutaneously infecte
Brazilian Journal of Medical and Biological Research. Publicado em: 2006-07
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8. Expressão precoce de CD34, CD68, α-actina de músculo liso e COX-2 no estroma pericriptal durante carcinogênese colônica induzida quimicamente em ratos. / Early Expression of CD34, CD68, α-smooth muscle actin and COX-2 in pery-crypt stroma during chemically-induced rat colonic carcinogenesis.
There has been considerable that the activity of epithelial cells with their stroma is fundamental in controlling growth and differentiation in normal and pathological situations, including cancer. A number of reports stress the importance of the stromal compartment in malignant tumors and strongly indicate that continuous interactions between the carcinoma
Publicado em: 2006
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9. Effect of the use of the Orlistat in the cellular proliferation of the colônica mucosa and in the formation of induced aberrant focos of criptas for Dimetilhidrazina in rats. / Efeitos do Orlistat na proliferação celular da mucosa colônica e na formação de focos de criptas aberrantes induzidos por Dimetilhidrazina em ratos
O Orlistat é um membro de uma classe de drogas usadas como tratamento para obesidade. No entanto, a segurança de seu uso em longo prazo ainda não é conhecida. O Orlistat exerce sua atividade no lúmen do trato gastrintestinal inibindo a enzima lipase pancreática, responsável pela hidrólise dos triacilglicerídeos normalmente ingeridos com a dieta. Ess
Publicado em: 2006
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10. Study of the toxicity induced by the anti-inflammatory sulindac and its metabolites, sulindac sulfone and sulindac sulfide / Estudo da toxicidade induzida pelo antiinflamatório sulindaco e seus metabólitos sulfona e sulfeto
Sulindac is a nonsteroidal anti-inflammatory drug (NSAID) known to inhibit non-selectively ciclooxygenases (COX) 1 and 2. Sulindac is therapeutically used as anti-inflammatory and analgesic in the symptomatic treatment of acute and chronic rheumatoid arthritis, osteoarthritis, and ankylosing spondylits. In addition to this property, a role in the prevention/
Publicado em: 2006
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11. Genetics of colon cancer.
Strikingly rapid advances in the identification of genetic events that are important in colonic carcinogenesis have been made in the past several years. Specific inherited (adenomatous polyposis coli gene) and acquired (ras gene point mutations; c-myc gene amplification; allelic deletion at specific sites on chromosomes 5, 17, and 18) genetic abnormalities a
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12. Targeted Genetic Disruption of Peroxisome Proliferator–Activated Receptor-δ and Colonic Tumorigenesis
Peroxisome proliferator–activated receptor-delta (PPAR-δ) is overexpressed in human colon cancer, but its contribution to colonic tumorigenesis is controversial. We generated a mouse model in which PPAR-δ was genetically disrupted in colonic epithelial cells by targeted deletion of exon 4. Elimination of colon-specific PPAR-δ expression was confirmed by
Oxford University Press.