Cholesteryl Ester Transfer Proteins
Mostrando 1-12 de 12 artigos, teses e dissertações.
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1. A expressão da proteína de transferência de colesteril éster (CETP) modula a adiposidade e a expressão de genes envolvidos em lipólise e lipogênese / Cholesteryl ester transfer protein (CETP) expression modulates adiposity and expression of genes involved in lipolysis and lipogenesis
A CETP é uma proteína plasmática que promove a transferência de lípides entre lipoproteínas, causando redução de HDL-colesterol e, portanto, aumento do risco de aterosclerose. Neste trabalho, investigamos o efeito da expressão desta proteína sobre a adiposidade e a expressão diferencial de genes em dois modelos animais. Inicialmente, comparamos ca
Publicado em: 2010
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2. Efeito de acidos graxos n-3 e n-6 sobre a expressão e atividade da proteina de transferencia de colesteril ester (CETP) em camundongos transgenicos / Effects of n-3 and n-6 fatty acids on the cholesteryl ester transfer protein (CETP) expression and activity in transgenic mice
Os óleos de peixe e de milho são fontes de ácidos graxos poli-insaturados (PUFA) n-3 e n-6, respectivamente. Estes ácidos graxos são ligantes naturais dos receptores ativados por proliferadores de peroxissomos (PPARs) e, dessa forma, modificam a expressão de diversos genes envolvidos no metabolismo de lipídios. A proteína de transferência de coleste
Publicado em: 2008
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3. Lipemia postrandial in the alterations of the activities in the cholesterol ester transfer protein or hepatic lipase in human and rodents / Lipemia pos-prandial nas alterações das atividades da proteina de tranferencia de esteres de colesterol ou da lipase hepatica em humanos e em roedores
The postprandial response to a fat overload presents proatherogenic direct effects with remanescent lipoproteins deposition in arterial walls and indirect on the triglycerides-rich lipoprotein metabolism. Alterations during the postprandial lipemia are related with the activities of cholesteryl ester transfer protein and hepatic lipase. These two proteins po
Publicado em: 2007
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4. Efeito da expressão da proteina de transferencia de colesteril ester (CETP) sobre o metabolismo das lipoproteinas ricas em triglicerides e adiposidade em camundongos transgenicos / Effects of cholesteryl ester transfer protein (CETP) expression on triglyceride rich lipoprotein metabolism and adiposity in transgenic mice
Neste trabalho investigamos o efeito da expressão de genes envolvidos no transporte e redistribuição de triglicérides das lipoproteínas plasmáticas, a apolipoproteína (apo) CIII e a proteína de transferência de colesteril éster (CETP), sobre o metabolismo de triglicérides pós-prandial e sobre a formação de depósitos adiposos regionais em camun
Publicado em: 2007
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5. Metabolismo de lipoproteinas plasmaticas em tabagistas : proteinas reguladoras e modificações quimicas das lipoproteinas de baixa densidade
A aterosclerose é uma doença imuno-inflamatória e de caráter multifatorial. O tabagismo é um de seus principais fatores de risco, existindo grande controvérsia na literatura quanto aos mecanismos fisiopatológicos de sua aterogenicidade. Avaliamos os efeitos metabólicos e oxidantes do fumo em urna população sadia adulta, composta de fumantes crônic
Publicado em: 2002
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6. Isolation and specificity of a Mr 74,000 cholesteryl ester transfer protein from human plasma.
A cholesteryl ester transfer protein was isolated from human plasma whose ligand specificity, molecular weight, and amino acid composition are significantly different from those of proteins previously reported to have this activity. The protein, purified about 100,000-fold from plasma, is rich in hydrophobic amino acids, especially leucine. It has a molecula
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7. Plasma phospholipid transfer protein, cholesteryl ester transfer protein and lecithin:cholesterol acyltransferase in end-stage renal disease (ESRD)
Background. Chronic kidney disease (CKD) results in accelerated atherosclerosis that is primarily caused by inflammation, oxidative stress and impaired triglyceride and HDL metabolisms. Several plasma proteins including phospholipid transfer protein (PTLP), cholesteryl ester transfer protein (CETP) and lecithin:cholesterol acyltransferase (LCAT) affect HDL m
Oxford University Press.
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8. Synthesis and secretion of wild-type and mutant human plasma cholesteryl ester transfer protein in baculovirus-transfected insect cells: the carboxyl-terminal region is required for both lipoprotein binding and catalysis of transfer.
Functional plasma cholesteryl ester transfer protein (CETP; 476 amino acids) has been expressed in baculovirus-transfected Sf9 insect cells by using a full-length cDNA derived from a human placental library. The product bound to each major plasma lipoprotein class, and it catalyzed the transfer of both cholesteryl esters and triglyceride. CETP species with o
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9. Abnormalities in very low, low and high density lipoproteins in hypertriglyceridemia. Reversal toward normal with bezafibrate treatment.
The effects of triglyceridemia on plasma lipoproteins were investigated in 16 hypertriglyceridemic (HTG) subjects (222-2,500 mg/dl) before and after the initiation of bezafibrate therapy. Bezafibrate caused a mean reduction of 56% in plasma triglyceride and increased the levels of lipoprotein and hepatic triglyceride lipases by 260 and 213%, respectively. Th
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10. Distribution and concentration of cholesteryl ester transfer protein in plasma of normolipemic subjects.
A MAb (TP-2) directed against human cholesteryl ester transfer protein (CETP) has been applied to the development of a competitive solid-phase RIA. Experiments with immobilized CETP have shown that upon incubation with plasma or HDL in the presence of Tween (0.05%) apo A-I (but not apo A-II) binds to CETP while TP-2 binding to CETP is concomitantly decreased
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11. Cholesterol efflux potential of sera from mice expressing human cholesteryl ester transfer protein and/or human apolipoprotein AI.
The ability of whole serum to promote cell cholesterol efflux and the relationships between apoprotein and lipoprotein components of human serum efflux have been investigated previously (de la Llera Moya, M., V. Atger, J.L. Paul, N. Fournier, N. Moatti, P. Giral, K.E. Friday, and G.H. Rothblat. 1994. Arterioscler. Thromb. 14:1056-1065). We have now used this
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12. Targeted mutation of plasma phospholipid transfer protein gene markedly reduces high-density lipoprotein levels
It has been proposed that the plasma phospholipid transfer protein (PLTP) facilitates the transfer of phospholipids and cholesterol from triglyceride-rich lipoproteins (TRL) into high-density lipoproteins (HDL). To evaluate the in vivo role of PLTP in lipoprotein metabolism, we used homologous recombination in embryonic stem cells and produced mice with no P
American Society for Clinical Investigation.