Lipemia postrandial in the alterations of the activities in the cholesterol ester transfer protein or hepatic lipase in human and rodents / Lipemia pos-prandial nas alterações das atividades da proteina de tranferencia de esteres de colesterol ou da lipase hepatica em humanos e em roedores

AUTOR(ES)
DATA DE PUBLICAÇÃO

2007

RESUMO

The postprandial response to a fat overload presents proatherogenic direct effects with remanescent lipoproteins deposition in arterial walls and indirect on the triglycerides-rich lipoprotein metabolism. Alterations during the postprandial lipemia are related with the activities of cholesteryl ester transfer protein and hepatic lipase. These two proteins possess ambiguous roles in the development of atherosclerosis and their performance on the triglycerides-rich lipoprotein metabolism is very scarcely described in the literature. We studied the metabolic repercussions in assimptomatics women (n=28) after a single liquid and rich in fat oral meal in individuals presenting primary deficiency of CETP and HL with serial collections of blood up to 8h. The selection of participants was made through cutoff values for CETP and HL either equal or lower or equal or higher than percentiles 10 and 90 of a normolipidemic population (n=129). The individuals that presented activities of proteins between percentiles 10 and 90 were selected as controls. In a a case-report here described a woman who presented multiple deficiencies (CETP= -79% and HL= -88%) had increased postprandial lipemia that was attenuated one year of hormonal treatment with Tibolona, a result not described yet in the literature. Analyzing a group of 6 individuals with an average CETP increase of 33%, we obtained postprandial lipids curves similar to controls, in a sharp contrast with the case report with increased lipemia and CETP deficiency. This model demonstrates an absence of a CETP effect on triglyceride rich lipoprotein during its moderate increase, probably due the lack of changes in the reverse cholesterol transport and also the absence of a direct effect of the transfer protein on triglyceride-rich lipoprotein metabolism. As well postprandial studies using rodent models were performed; we observed after an oral overload of fat that mice of both the sexes and female rats present postprandial lipemia with characteristics similar to normolipidemic humans. A distinguished response was observed in male rats that are more sensible to the diet with the presence of the delayed and late lipemia

ASSUNTO(S)

cetp aterosclerose lipase cholesterol ester transfer proteins atherosclerosis lipase proteinas de transferencia de esteres de colesterol

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