Chemoprevention
Mostrando 1-12 de 64 artigos, teses e dissertações.
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1. Cytotoxic and apoptotic potential of Myristica fragrans Houtt. (mace) extract on human oral epidermal carcinoma KB cell lines
Several studies have revealed that certain naturally occurring medicinal plants inhibit the growth of various cancers. The present study was conducted to evaluate cytotoxicity and apoptotic induction potential of Myristica fragrans Houtt mace extract. The cytotoxic activity of the Myristica fragrans Houtt mace acetone extract was assayed by MTT assay on huma
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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2. The impacts of Elaeagnus umbellata Thunb. leaf and fruit aqueous extracts on mice hepatic, extrahepatic antioxidant and drug metabolizing enzymes related structures
ABSTRACT In this work, the potential chemopreventive activities of Elaeagnus umbellata fruit aqueous (EUFA) and leaf aqueous (EULA) extracts focusing on the modulatory influence of xenobiotic metabolizing enzymes (XMEs), antioxidant enzymes, glucose-6-phosphate dehydrogenase (G6PD), 6-phosphogluconate dehydrogenase (6PGD), lactate dehydrogenase (LDH) activit
Braz. J. Pharm. Sci.. Publicado em: 01/02/2018
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3. Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives
ABSTRACT Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by syn
Braz. J. Pharm. Sci.. Publicado em: 08/01/2018
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4. Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium
Hedychium coronarium J. Koenig, Zingiberaceae, is a medicinal plant popularly used to treat inflammatory conditions in different countries. Three labdane diterpenes [isocoronarin D (1), methoxycoronarin D (2), ethoxycoronarin D (3)] and benzoyl eugenol (4) were isolated from rhizomes and their chemopreventive potential was evaluated using in vitro assays, n
Rev. bras. farmacogn.. Publicado em: 2014-08
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5. Five-alpha Reductase Inhibitor Influences Expression of Androgen Receptor and HOXB13 in Human Hyperplastic Prostate Tissue
Objectives Five-alpha reductase inhibitors (5ARIs) are known as chemopreventive agents in prostate cancer with a risk of high-grade disease. This study evaluated the effects of 5ARI on androgen receptor (AR) and proteins involved in prostate cell growth such as HOXB13 expression in human prostate tissue and LNCaP prostate cancer cells. Materials and Method
Int. braz j urol.. Publicado em: 2013-12
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6. Viral inactivation in hemotherapy: systematic review on inactivators with action on nucleic acids
The aim of this study was to conduct a systematic review on the photoinactivators used in hemotherapy, with action on viral genomes. The SciELO, Science Direct, PubMed and Lilacs databases were searched for articles. The inclusion criterion was that these should be articles on inactivators with action on genetic material that had been published between 2000
Revista Brasileira de Hematologia e Hemoterapia. Publicado em: 2012
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7. âEstudo QuÃmico e AvaliaÃÃo Quimiopreventiva de Humirianthera ampla Miers, Simarouba versicolor e cinco espÃcies do gÃnero Lippia.â / Chemical study and chemopreventive evaluation of Humirianthera ampla Miers, Simarouba versicolor and five species of the Lippia genera.â
Humirianthera ampla Miers (Icacinaceae), Simarouba verscicolor A. St.-Hil. (Simaroubaceae), Lippia Alba (Mill) N.E. Br. (quimiotipos carvoneifera, citralifera e mirceneifera), Lippia gracillis Schauer e Lippia sidoides Cham., foram avaliadas como provÃveis fontes de compostos bioativos possuidores de atividade anticÃncer (antioxidante e/ou citotÃxica) atr
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 18/05/2011
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8. Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis
β-ionone (βI), a cyclic isoprenoid, and geraniol (GO), an acyclic monoterpene, represent a promising class of dietary chemopreventive agents against cancer, whose combination could result in synergistic anticarcinogenic effects. The chemopreventive activities of βI and GO were evaluated individually or in combination during colon carcinogenesis induced by
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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9. Indicações e adesão adequadas da quimioprofilaxia como prevenção entre os contatos de pacientes com tuberculose, no município de Palmas TO / Adequate indications and adhesion of the chemoprevention as prevention enter the contacts of patients with tuberculosis, in the city of Palmas TO.
The tuberculosis is a infectum-contagious illness, caused by the Mycobacterium tuberculosis, in Brazil the tuberculosis consists in a serious problem of public health, although to be the first country in the world to implant the treatment of short duration, with multidrugs that guarantee the cure in six months. The chemoprevention is a preventive form of con
Publicado em: 2011
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10. Efeito da finasterida e da doxazosina sobre a próstata de rato : análise ultra-estrutural e da expressão dos colágenos tipo I e III e do TGF-b 1 / Finasteride and doxazosin effects on rat prostate : ultrastructural and type Iand type III and TGF-1 expression analyses
Finasteride and doxazosin are drugs used in the benign prostatic hyperplasia (BPH) treatment and, more recently, they re have been used in the prostate cancer (PCa) chemoprevention, mainly because their apoptotic effect in the prostatic epithelial cells. However, few attentions have been given to the effects of these drugs in the glandular stroma. Thus, the
Publicado em: 2010
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11. Lack of chemopreventive activity of vitamin A when administered to rats during the stage of post-initiation of mammary carcinogenesis / Ausência de atividade quimiopreventiva por parte da vitamina A quando administrada a ratas na etapa de pós-iniciação da carcinogênese mamária
Avaliou-se a eventual atividade quimiopreventiva por parte da vitamina A (VA) quando administrada a ratas Sprague-Dawley durante a etapa de pós-iniciação da carcinogênese mamária induzida pelo 7-12 dimetilbenz(a)antraceno (DMBA). Com exceção de 10 animais que constituíram um grupo controle à parte de ratas consideradas normais [grupo normal (N)], e
Publicado em: 2010
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12. Differential gene expression profiles of hepatocellular carcinomas associated or not with viral infection
Chronic hepatitis B (HBV) and C (HCV) virus infections are the most important factors associated with hepatocellular carcinoma (HCC), but tumor prognosis remains poor due to the lack of diagnostic biomarkers. In order to identify novel diagnostic markers and therapeutic targets, the gene expression profile associated with viral and non-viral HCC was assessed
Brazilian Journal of Medical and Biological Research. Publicado em: 06/11/2009