Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives
AUTOR(ES)
Moro, Isabela Jacob, Gondo, Gabrielle Demmany Gualberto Alexandre, Pierri, Elaíse Gonçalves, Pietro, Rosemeire Cristina Linharis Rodrigues, Soares, Christiane Pienna, Sousa, Damião Pergentino de, Santos, André Gonzaga dos
FONTE
Braz. J. Pharm. Sci.
DATA DE PUBLICAÇÃO
08/01/2018
RESUMO
ABSTRACT Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by synthesis using (+)-carvone (C+) or (-)-carvone (C-) as precursors. The antifungal activity (MIC and MFC) were evaluated against Candida parapsilosis, C. tropicalis, C. krusei and C. albicans and the antibacterial activity (MIC and MBC) against Escherichia coli and Staphylococcus aureus. The cytotoxicity assays were performed with human cancer cell lines HepG-2 and SiHa and the normal strain MRC-5 through sulphorrodamine B assay. Chemoprevention was evaluated through quinone reductase assay. Our results showed no cytotoxicity on tumor and normal cell lines and no induction of the quinone reductase enzyme. C- and HC- presented activity against E. coli. All compounds presented weak antifungal activity against C. tropicalis and C. parapsilosis. EP and C+ showed moderate activity against C. krusei. Results suggest the potential use of carvones and its derivatives as antifungal agents against Candida yeasts. The absence of cytotoxicity in cell lines indicates safety in the use of these compounds.
Documentos Relacionados
- CHEMICAL CONSTITUENTS OF Sinningia mauroana AND SCREENING OF ITS EXTRACTS FOR ANTIMICROBIAL, ANTIOXIDANT AND CYTOTOXIC ACTIVITIES
- Synthesis and evaluation of arylamidine derivatives for new antimicrobial and cytotoxic activities
- Antioxidant, hemolytic, antimicrobial, and cytotoxic activities of the tropical Atlantic marine zoanthid Palythoa caribaeorum
- Antimicrobial, Anti-Inflammatory and Antioxidant Activities of Polyoxygenated Chalcones
- Antimicrobial, Antioxidant and Cytotoxic Activity of MarineStreptomyces parvulus VITJS11 Crude Extract