Cardiac Biomarkers
Mostrando 25-34 de 34 artigos, teses e dissertações.
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25. Isoflurano : desenvolvimento de um método analítico empregando microextração em fase sólida, incorporação em nanoemulsões e avaliação biológica das nanoemulsões
The aims of this work were to develop and validate an analytical method using solidphase microextraction (SPME) to detect and quantify isoflurane (ISO) inhalation liquid and loaded in intravenous nanoemulsions, and also evaluate the biological effect of the formulations. ISO detection was made by gas chromatography with flame ionization detector (GC/FID). Th
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 2010
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26. Alterações das concentrações plasmáticas de troponina I e de metaloproteinases 2 e 9 da matriz extracelular após embolia aguda em cães / Severity dependent increases in circulating cardiac troponin I and MMP-2 and 9 concentrations after experimental acute pulmonary thromboembolism
Making the diagnosis of acute pulmonary thromboembolism (APT) and assessing its severity is very challenging. While cardiac troponin I (CTI) levels are promising in risk stratification, no previous study has examined whether there is a linear relation between CTI levels and the severity of APT. Moreover, matrix metalloproteinases (MMPs) are involved in the p
Publicado em: 2008
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27. Quantification of Cardiovascular Biomarkers in Patient Plasma by Targeted Mass Spectrometry and Stable Isotope Dilution*
Verification of candidate biomarkers requires specific assays to selectively detect and quantify target proteins in accessible biofluids. The primary objective of verification is to screen potential biomarkers to ensure that only the highest quality candidates from the discovery phase are taken forward into preclinical validation. Because antibody reagents f
The American Society for Biochemistry and Molecular Biology.
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28. Urinary Biomarkers in the Early Detection of Acute Kidney Injury after Cardiac Surgery
Background and objectives: Serum creatinine (Scr) does not allow for early diagnosis of acute kidney injury (AKI). The diagnostic utility of urinary kidney injury molecule-1 (KIM-1), N-acetyl-β-D-glucosaminidase (NAG), and neutrophil gelatinase associated lipocalin (NGAL) was evaluated for the early detection of postoperative AKI in a prospective study of 9
American Society of Nephrology.
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29. Implications of troponin testing in clinical medicine
During the past decade considerable research has been conducted into the use of cardiac troponins, their diagnostic capability and their potential to allow risk stratification in patients with acute chest pain. Determination of risk in patients with suspected myocardial ischaemia is known to be as important as retrospective confirmation of a diagnosis of myo
BioMed Central.
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30. Identification of biochemical adaptations in hyper- or hypocontractile hearts from phospholamban mutant mice by expression proteomics
Phospholamban (PLN) is a critical regulator of cardiac contractility through its binding to and regulation of the activity of the sarco(endo)plasmic reticulum Ca2+ ATPase. To uncover biochemical adaptations associated with extremes of cardiac muscle contractility, we used high-throughput gel-free tandem MS to monitor differences in the relative abundance of
National Academy of Sciences.
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31. Sarcalumenin is essential for maintaining cardiac function during endurance exercise training
Sarcalumenin (SAR), a Ca2+-binding protein located in the longitudinal sarcoplasmic reticulum (SR), regulates Ca2+ reuptake into the SR by interacting with cardiac sarco(endo)plasmic reticulum Ca2+-ATPase 2a (SERCA2a). We have previously demonstrated that SAR deficiency induced progressive heart failure in response to pressure overload, despite mild cardiac
American Physiological Society.
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32. New methods for improved evaluation of patients with suspected acute coronary syndrome in the emergency department
This paper aims to identify and review new and unproven emergency department (ED) methods for improved evaluation in cases of suspected acute coronary syndrome (ACS). Systematic news coverage through PubMed from 2000 to 2006 identified papers on new methods for ED assessment of patients with suspected ACS. Articles found described decision support models, ne
BMJ Group.
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33. Pharmacological Inhibition of Transforming Growth Factor β Signaling Decreases Infection and Prevents Heart Damage in Acute Chagas' Disease▿
Chagas' disease induced by Trypanosoma cruzi infection is an important cause of mortality and morbidity affecting the cardiovascular system for which presently available therapies are largely inadequate. We previously reported that transforming growth factor β (TGF-β) is implicated in several regulatory aspects of T. cruzi invasion and growth and in host t
American Society for Microbiology (ASM).
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34. Overexpression of Peroxiredoxin 6 Does Not Prevent Ethanol-Mediated Oxidative Stress and May Play a Role in Hepatic Lipid Accumulation
Oxidative stress is implicated in the etiology of many diseases, including alcoholic liver disease (ALD). Peroxiredoxin 6 is a cytosolic peroxidase that has been demonstrated to protect various tissues, such as skin, lung, and cardiac muscle, against acute oxidative insults. Consequently, peroxiredoxin 6 was hypothesized to also protect the liver from ox
American Society for Pharmacology and Experimental Therapeutics.