Cancer Chemoprevention
Mostrando 1-12 de 46 artigos, teses e dissertações.
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1. Cytotoxic and apoptotic potential of Myristica fragrans Houtt. (mace) extract on human oral epidermal carcinoma KB cell lines
Several studies have revealed that certain naturally occurring medicinal plants inhibit the growth of various cancers. The present study was conducted to evaluate cytotoxicity and apoptotic induction potential of Myristica fragrans Houtt mace extract. The cytotoxic activity of the Myristica fragrans Houtt mace acetone extract was assayed by MTT assay on huma
Braz. J. Pharm. Sci.. Publicado em: 29/11/2018
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2. Evaluation of antimicrobial, cytotoxic and chemopreventive activities of carvone and its derivatives
ABSTRACT Considering the reported activity of carvone in the literature, this study aimed to evaluate the antimicrobial, cytotoxic and chemopreventive activities of (+)- and (-)-carvone, (+)- and (-)- hydroxydihydrocarvone and α,β-epoxycarvone. (+)-Hydroxydihydrocarvone (HC+), (-)-hydroxydihydrocarvone (HC-) and α,β-epoxycarvone (EP) were obtained by syn
Braz. J. Pharm. Sci.. Publicado em: 08/01/2018
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3. Cancer chemoprevention activity of labdane diterpenes from rhizomes of Hedychium coronarium
Hedychium coronarium J. Koenig, Zingiberaceae, is a medicinal plant popularly used to treat inflammatory conditions in different countries. Three labdane diterpenes [isocoronarin D (1), methoxycoronarin D (2), ethoxycoronarin D (3)] and benzoyl eugenol (4) were isolated from rhizomes and their chemopreventive potential was evaluated using in vitro assays, n
Rev. bras. farmacogn.. Publicado em: 2014-08
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4. Five-alpha Reductase Inhibitor Influences Expression of Androgen Receptor and HOXB13 in Human Hyperplastic Prostate Tissue
Objectives Five-alpha reductase inhibitors (5ARIs) are known as chemopreventive agents in prostate cancer with a risk of high-grade disease. This study evaluated the effects of 5ARI on androgen receptor (AR) and proteins involved in prostate cell growth such as HOXB13 expression in human prostate tissue and LNCaP prostate cancer cells. Materials and Method
Int. braz j urol.. Publicado em: 2013-12
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5. Efficacy of geraniol but not of β-ionone or their combination for the chemoprevention of rat colon carcinogenesis
β-ionone (βI), a cyclic isoprenoid, and geraniol (GO), an acyclic monoterpene, represent a promising class of dietary chemopreventive agents against cancer, whose combination could result in synergistic anticarcinogenic effects. The chemopreventive activities of βI and GO were evaluated individually or in combination during colon carcinogenesis induced by
Brazilian Journal of Medical and Biological Research. Publicado em: 2011-06
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6. Efeito da finasterida e da doxazosina sobre a próstata de rato : análise ultra-estrutural e da expressão dos colágenos tipo I e III e do TGF-b 1 / Finasteride and doxazosin effects on rat prostate : ultrastructural and type Iand type III and TGF-1 expression analyses
Finasteride and doxazosin are drugs used in the benign prostatic hyperplasia (BPH) treatment and, more recently, they re have been used in the prostate cancer (PCa) chemoprevention, mainly because their apoptotic effect in the prostatic epithelial cells. However, few attentions have been given to the effects of these drugs in the glandular stroma. Thus, the
Publicado em: 2010
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7. The effect of the vitamin E and selenium in the mucositis prevention in patients with upper aero-digestive ductsmalign tumors submitted to radiotherapy concomitant or not with chemotherapy / O efeito da vitamina E e do selênio na prevenção da mucosite em pacientes com tumores malignos nas vias aerodigestivas superiores submetidos a radioterapia, concomitantemente ou não com quimioterapia
A utilização da radioterapia e da quimioterapia em maior escala no tratamento do câncer de cabeça e pescoço tem elevado a incidência de efeitos colaterais, em especial da mucosite bucal. O presente estudo estabeleceu como objetivo a avaliação do efeito da suplementação da vitamina E e do selênio na prevenção da mucosite causada pela radioterapia
Publicado em: 2009
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8. Anticancer activity of Calea pinnatifida banks leaves crude extract and fractions / Atividade anticancer do extrato bruto e das frações das folhas de Calea pinnatifida banks
Plants have provided a rich source of therapeutic agents for many centuries useful as themselves or the basis for synthetic drugs. Nowadays, the biology of cancer has been studied manly for the chemoprevention drug discovery. As plants and drugs based on plants have a lot of different structures and function they could be source of new drugs for cancer chemo
Publicado em: 2008
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9. Efeito protetor do betacaroteno contra a ação genotóxica da doxorrubicina, em células somáticas de Drosophila melanogaster
O betacaroteno (BC), pró-vitamina A, é um eficiente antioxidante, efetivo na neutralização de espécies reativas de oxigênio, que estão relacionadas a sérios danos causados ao DNA, lipídios e proteínas. Por isso, observa-se a progressão nos estudos referentes à ação do BC na quimioprevenção de câncer e doenças do coração. Esses avanços pr
Publicado em: 2008
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10. Sobre os efeitos quimiopreventivos e antitumorais do guaraná, Paullinia cupana Mart var. sorbilis, em modelos experimentais in vivo e in vitro / On the chemopreventive and antineoplastic effects of guarana, Paullinia cupana Mart var. sorbilis, in in vivo and in vitro experimental models
O câncer é a segunda maior causa de morte no Brasil, atrás apenas de doenças cardíacas. Por isto, é evidente que grandes recursos sejam direcionados para a pesquisa no descobrimento de novas opções com a finalidade de erradicar esta doença. Dentre estas opções, a quimioprevenção do câncer tem chamado a atenção já que, mesmo com os imensos av
Publicado em: 2008
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11. Efeito protetor do chá verde (Camellia sinensis) contra a ação genotóxica da doxorrubicina, em células somáticas de Drosophila melanogaster
The green tea is considered a functional food with antioxidant activity, and this delays the process of old age and helps in the prevention of chronicle and degenerative diseases, such as cancer and heart affections. Of catechins, present in green tea, may is extremely important in the inactivation of free radicals, which provoke damages to the DNA molecules
Publicado em: 2008
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12. Mecanismo da ação antineoplasica de substancias bioativas e alvos moleculares estrategicos para a indução de morte de celulas tumorais / Antineoplastic action mechanism of bioactive compounds and strategical molecular targets for inducting tumoral cells death
Natural products have been providing numerous clinically used medicines and remain as essential components in the search for new drugs against various pharmacological targets including cancer, HIV/AIDS, Alzheimer?s, malaria, and pain. Drug discovery from natural products, especially from medicinal plants, has played an important role in the chemoprevention a
Publicado em: 2007