Cancer Chemoprevention
Mostrando 13-24 de 46 artigos, teses e dissertações.
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13. Inibição de danos em DNA e alteração da expressão gênica em ratos Wistar tratados com as hortaliças couve e repolho (Brassica oleracea) e submetidos à hepatocarcinogênese química / Inhibition in DNA damages and differential gene expression in Wistar rats treated with kale and cabbage (Brassica oleracea) and submitted to chemical hepatocarcinogenesis
O câncer é a segunda maior causa de morte no mundo, sendo responsável por aproximadamente 7,6 milhões de óbitos. Entretanto, pesquisadores alertam para uma associação inversa entre o consumo de frutas e hortaliças e o desenvolvimento de neoplasias, desta forma a organização mundial da saúde sugere, dentre outras medidas para controle do câncer, o
Publicado em: 2007
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14. Química e atividades biológicas de Hancornia speciosa Gomes (Apocynaceae):: inibição da enzima conversora de angiotensina (ECA) e efeito na quimioprevenção de câncer
Hancornia speciosa Gomes (Apocynaceae) is a plant species found in cerrado, a savannahlike vegetation, popularly used to treat hypertension and inflammatory processes. Its potential anti-hypertensive activity has been previously demonstrated by in vitro inhibition of angiotensin converting enzyme (ACE) and vasodilatation in rat aortic rings. Several studies
Publicado em: 2007
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15. Finasteride effects on epithelium-stroma interaction in the different rat prostatic lobes / Efeito da finasterida sobre a interação epitelio-estroma nos diferentes lobos da prostata de rato
Prostate cancer cells are generally dependent on androgen stimulation mediated by the androgen receptor (AR) for growth and survival. Therefore, hormonal manipulation, such as castration and/or the use of AR antagonists, results in a regression of the cancer. However, these treatments very rarely lead to the cure of advanced disease and cancer eventually bec
Publicado em: 2006
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16. Phyto-oestrogens and breast cancer chemoprevention
Phytoestrogens are polyphenol compounds of plant origin that exhibit a structural similarity to the mammalian steroid hormone 17β-oestradiol. In Asian nations the staple consumption of phyto-oestrogen-rich foodstuffs correlates with a reduced incidence of breast cancer. Human dietary intervention trials have noted a direct relationship between phyto-oestrog
BioMed Central.
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17. Chemoprevention of breast cancer: A joint guideline from the Canadian Task Force on Preventive Health Care and the Canadian Breast Cancer Initiative's Steering Committee on Clinical Practice Guidelines for the Care and Treatment of Breast Cancer
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18. Osteopontin is a potential target gene in mouse mammary cancer chemoprevention by Se-methylselenocysteine
BioMed Central.
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19. Future possibilities in the prevention of breast cancer: Breast cancer prevention trials
The available results from breast cancer chemoprevention trials are reviewed. Four trials using tamoxifen have been performed, of which three have reported efficacy results. A fifth trial using raloxifene has also been reported. The largest tamoxifen trial showed approximately 50% reduction in breast cancer incidence in the short term, but the two smaller tr
BioMed Central.
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20. Dietary Sulforaphane, a Histone Deacetylase Inhibitor for Cancer Prevention12
The reversible acetylation of histones is an important mechanism of gene regulation. During prostate cancer progression, specific modifications in acetylation patterns on histones are apparent. Targeting the epigenome, including the use of histone deacetylase (HDAC) inhibitors, is a novel strategy for cancer chemoprevention. Recently, drugs classified as HDA
American Society for Nutrition.
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21. Mechanisms underlying nonsteroidal antiinflammatory drug-mediated apoptosis
Nonsteroidal antiinflammatory drugs (NSAIDs) can inhibit colorectal tumorigenesis and are among the few agents known to be useful for the chemoprevention of neoplasia. Here, we show that the tumor suppressive effects of NSAIDs are not likely to be related to a reduction in prostaglandins but rather are due to the elevation of the prostaglandin precursor arac
The National Academy of Sciences.
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22. Breast cancer chemoprevention: beyond tamoxifen
A large number of new potential chemoprevention agents are available that target molecular abnormalities found in estrogen receptor (ER)-negative and/or ER-positive precancerous breast tissue and have side effect profiles that differ from tamoxifen. Classes of agents currently undergoing evaluation in clinical prevention trials or those for which testing is
BioMed Central.
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23. Lipoxygenase and cyclooxygenase metabolism: new insights in treatment and chemoprevention of pancreatic cancer
The essential fatty acids, linoleic acid and arachidonic acid play an important role in pancreatic cancer development and progression. These fatty acids are metabolized to eicosanoids by cyclooxygenases and lipoxygenases. Abnormal expression and activities of both cyclooxygenases and lipoxygenases have been reported in pancreatic cancer. In this article, we
BioMed Central.
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24. The contribution of inherited genotype to breast cancer
The etiology of breast cancer is complex, and is likely to involve the actions of genes at multiple levels along the multistage carcinogenesis process. These inherited genotypes include those that affect the propensity to be exposed to breast carcinogens, and those associated with breast tumorigenesis directly. In addition, inherited genotypes may influence
BioMed Central.