Bothropic Venom
Mostrando 1-12 de 27 artigos, teses e dissertações.
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1. Creolin® administered by different pathways in rats experimentally poisoned with Bothrops jararaca venom
RESUMO: Esse estudo objetivou avaliar os efeitos da Creolina® quando administrada por diferentes vias de acesso em ratos experimentalmente envenenados pela peçonha de Bothrops jararaca. Em ratas Wistar fêmeas foi inoculada a peçonha botrópica por via intramuscular, e em seguida as ratas foram tratadas com Creolina® (administrada oralmente, topicamente
Cienc. Rural. Publicado em: 11/04/2019
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2. Can anti-bothropstoxin-I antibodies discriminate between Bothrops jararaca and Bothrops jararacussu venoms?
Abstract Background Snakes of the genus Bothrops, popularly known as pit vipers, are responsible for most cases of snakebite in Brazil. Within this genus, Bothrops jararacussu and B. jararaca deserve special attention due to the severity of their bites and for inhabiting densely populated areas. Regarding the treatment of snakebites by Bothrops jararacussu
J. Venom. Anim. Toxins incl. Trop. Dis. Publicado em: 27/04/2017
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3. Evaluation of rat plasma proteins after bothropic venom inoculation and treatment with Mesenquimal stem cells
The aim of this work was to evaluate the mesenchymal stem cells treatment of rats with myonecrosis caused by Rhinocerophis alternatus venom through acute phase proteins (APP) profile. The animals were distributed into three experimental groups (G1, G2 and G3). G1 and G2 were inoculated with 120 μg of R. alternatus venom diluted in 200 µL of ultra-pure wate
Braz. arch. biol. technol.. Publicado em: 2014-02
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4. Cross-neutralization of the coagulant activity of Crotalus durissus terrificus venom from the northeast of Argentina by bivalent bothropic antivenom
Cross-neutralization of Crotalus durissus terrificus venom coagulant activity was tested using bivalent horse antivenom against Bothrops alternatus and Bothrops diporus venoms. Our in vitro and in vivo experiments showed that bothropic antivenom neutralizes the thrombin-like activity of crotalic snake venom and this cross-reaction was demonstrated by immunoa
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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5. Intradermal injection of Bothrops cotiara venom in mice in an experimental wound model
Bothropic envenomation induces hemorrhage, coagulant disturbances and necrosis. Regarding therapies against the local damage caused by the venom, there is little information on tissue changes until the complete healing. In the current study, local damage was evaluated by examination of morphological inflammatory alterations, mast cell count, and analysis of
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2012
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6. Caracterização bioquímica e funcional de uma metaloprotease isolada da peçonha da serpente bothrops moojeni
CHAPTER II: Bothrops snake venoms contain proteins that contribute to the local and systemic effects seen after envenoming, such as edema, myonecrosis, coagulation disorders and hemorrhage. These effects can be triggered by the toxic action of metalloproteinases present in the bothropic venom. This study aimed to perform the purification, biochemical and fun
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 26/07/2011
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7. Biological characterization of a myotoxin phosphoplipase A2 homologue purified from the venom of the snake Bothrops moojeni
A myotoxin phospholipase A2 homologue, BmooMtx, was isolated from the venom of Bothrops moojeni by a combination of ion-exchange chromatography on DEAE-Sephacel column and gel filtration on Sephadex G-75. SDS-PAGE showed the enzyme to be a monomer with a molecular weight of 16,500. BmooMtx induced release of creatine kinase and morphological analyses indicat
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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8. Triple bothropic envenomation in horses caused by a single snake
In the present study, snakebites caused by a single Bothrops pauloensis simultaneously affecting three male adult horses are described. Whereas the first two affected horses were six years old, the third was 16 years old; they weighed respectively 555, 550 and 500 kg. All horses presented swollen muzzles. The first animal received an initial antivenom dose o
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2011
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9. Heparin and commercial bothropic antivenom against the paralyzing effect of Bothrops jararacussu snake venom
The crude venom of Bothrops jararacussu (Bjssu) is known to induce muscular paralysis in vitro. Many studies have shown that various substances, including heparin, neutralize the damage caused by snake venom. In the present study, the ability of heparin (Hep) and commercial bothropic antivenom (CBA) to neutralize neuromuscular effects of Bjssu venom, at diff
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 26/02/2010
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10. IgG antibodies against phospholipase A2 from Crotalus durissus terrificus: cross-reaction with venoms from Bothrops species from Argentina
We examined the ability of IgG anti-crotalic PLA2 to cross-react with Bothrops spp. venoms, from snakes found in the northeast of Argentina. Immunoblotting and ELISA tests showed that IgG anti-crotalic PLA2 recognize antigens of bothropic venoms. Indirect hemolytic activity tests showed that the quantity of antibodies that neutralized 50% of Crotalus durissu
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2009
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11. Kinetics of venom and antivenom serum levels, clinical evaluation and therapeutic effectiveness in dogs inoculated with Crotalus durissus terrificus venom
This work evaluated the clinical and therapeutic aspects as well as serum levels of venom and antivenom IgG by enzyme-linked immunosorbent assay (ELISA) in experimental envenomation of dogs with Crotalus durissus terrificus venom. Twenty-eight mixed breed adult dogs were divided into four groups of seven animals each, Group I: only venom; Group II, venom + 5
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2008
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12. Construção de uma biblioteca de fragmentos de anticorpos monoclonais apresentados em fagos e seleção de clone neutralizante de toxinas presentes na peçonha de Bothrops pauloensis
Metaloproteinases são enzimas hidrolíticas do tipo endopeptidases que dependem da ligação de um metal, geralmente, o zinco, em seu sítio catalítico para manifestação de suas atividades. Estas enzimas são os principais componentes de peçonhas botrópicas responsáveis por seus efeitos hemorrágicos. Neste estudo foi construída uma biblioteca de fra
Publicado em: 2008