Bothropic Venom
Mostrando 13-24 de 27 artigos, teses e dissertações.
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13. Caracterização da DNase da peçonha da serpente Bothrops alternatus : comparação com a DNase acida de mamiferos envolvida em apoptose / Characterization of a Dnase from Bothrops alternatus snake venom : comparision with mamalian acid Dnases involved in apoptosis
Bothrops snake venoms are cytotoxic to a variety of cells (endothelial, smooth muscle, renal and inflammatory cells), and may cause cell death by apoptosis. The venom components implicated in apoptosis include metalloproteinases and L-amino acid oxidase. In contrast, although acidic deoxyribonucleases (DNase II) have been implicated in DNA fragmentation duri
Publicado em: 2008
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14. Estudo das atividades neurotoxica e miotoxica de uma fosfolipase A2 basica isolada do veneno total Bothrops marajoensis / Study of neurotoxic and myotoxic activities of a phospholipase A2 isolated from the Bothrops marajoensis venom
In the present work, the neuromuscular effects of the toxin Bmaj-9 isolated from the venom of Bothrops marajoensis in the laboratory of chemistry of proteins at Unicamp were studied. This toxin was assayed in biventer cervicis preparations of little chicken, phrenic diaphragm nerve of mice and in gastrocnemius muscles of mice. In birds preparation, Bmaj-9 ca
Publicado em: 2008
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15. Pharmacological characterization of ASP49 PLA2 isolated from Bothrops pauloensis venom / Caracterização farmacologica de uma fosfolipase A2 ASP49 isolada do veneno de Bothrops pauloensis
Bothropic venom has several substances necessary to serpent survival, among them, one of the most widely studied are phospholipase A2 enzymes, that hydrolise sn-2 from membrane phospholipids, releasing lysophospholipids and fatty acids, which beyond playing a biological action in the lipid digestion process, also exhibit a wide variety of pharmacological eff
Publicado em: 2008
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16. Biochemical and hematological study of goats envenomed with natural and 60Co-irradiated bothropic venom
Venoms from snakes of the Bothrops genus are proteolytic, coagulant, hemorrhagic and nephrotoxic, causing edema, necrosis, hemorrhage and intense pain at the bite site, besides systemic alterations. Many adjuvants have been added to the venom used in the sensitization of antiserum-producer animals to increase antigenic induction and reduce the envenomation p
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2007
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17. The influence of heparin at a low concentration agaist the myotoxicity of Bothrops jararacussu and bothropstoxin-I / A influencia da heparina em baixa concentração sobre a miotoxicidade do veneno de Bothrops jararacussu e bothropstoxina da heparina -I
Bothrops jararacussu venom (Bjssu) and its myotoxin bothropstoxin-I (BthTX-I) induce neurotoxicity and myotoxicity. Since the treatment with the antivenom is weakly efficient against the myotoxicity, many reports concentrate on studies utilizing substances that neutralize the myotixicity activity induced by the venom, including heparin. The objectives of thi
Publicado em: 2007
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18. Detection and neutralization of venom by ovine antiserum in experimental envenoming by Bothrops jararaca
In this study we optimized an enzyme-linked immunosorbent assay (ELISA) to evaluate bothropic venom levels in biological samples. These samples were obtained by two distinct protocols. In the first one, Swiss mice were injected with 1 LD50 of Bothrops jararaca (B. jararaca) venom and 15 minutes later, animals were treated with ovine antibothropic serum. Bloo
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2006
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19. Assessment of the neutralizing potency of ovine antivenom in a swiss mice model of Bothrops jararaca envenoming
Alternative sources of anti-ophidic serum are being investigated due to the secondary effects associated with types I and II hypersensitivity reactions. In the present study we raised and evaluated the protective effect of an ovine antibothropic serum in a Swiss mice envenoming model. Ovine antiserum was obtained by immunization with seven increasing doses o
Journal of Venomous Animals and Toxins including Tropical Diseases. Publicado em: 2005-09
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20. Atividade de plasmina simile e sequencia parcial de enzima fibrino(geno)litica do veneno de Bothrops lanceolatus (Fer de lance)
The main symptoms following bothropic envenoming are necroses, hemorrhage and coagulopathies, originating a characteristic and complex phisiopathology. The work of Lôbo de Araújo et al. (1998) described a single polipeptide chain protein (PII-1A) purified from Bothrops lanceolatus venom, a snake inhabitant of the Martinica island. The immunodiffusion and i
Publicado em: 2005
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21. Estudos estrutura-função de neurotoxinas isoladas de veneno crotálico e botrópico : análise comparativa de neurotoxicidade e mitoxicidade / Structure-function study of neurotoxins purified of crotalic and bothropic venom: comparative analysis of the neurotoxicity and myotoxicity
Through optimized methodologies of purification in HPLC, new toxins were purified from total venom of Crotalus durissus collilineatus (V-1), Bothrops jararacussus PLA2 D49 Bj-V (Bj-IV isoform) obtained from the fraction BthTX-II and Bothrops alternatus PLA2 K49 Bt II-2; with a high level of purity and molecular homogeneity, with no loss of biological activit
Publicado em: 2005
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22. Avaliação das lesões locais de cães envenenados experimentalmente com Bothrops alternatus após diferentes tratamentos
The aim of this study was to evaluate the therapeutic action of flunixin meglumine and aqueous extract of Curcuma longa (10%) on local lesions caused by bothropic venom, comparing with the specific antivenom. Twelve adult dogs were inoculated in the middle third of the lateral face of the thigh with 0.3mg/kg of venom. The dogs were divided into three groups
Arquivo Brasileiro de Medicina Veterinária e Zootecnia. Publicado em: 2003-10
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23. Evaluation of antivenoms in the neutralization of hyperalgesia and edema induced by Bothrops jararaca and Bothrops asper snake venoms
Neutralization of hyperalgesia induced by Bothrops jararaca and B. asper venoms was studied in rats using bothropic antivenom produced at Instituto Butantan (AVIB, 1 ml neutralizes 5 mg B. jararaca venom) and polyvalent antivenom produced at Instituto Clodomiro Picado (AVCP, 1 ml neutralizes 2.5 mg B. aspar venom). The intraplantar injection of B. jararaca a
Brazilian Journal of Medical and Biological Research. Publicado em: 2002-10
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24. Purificação e caracterização da fosfodiesterase do veneno de Bothrops alternatus (urutu)
A phosphodiesterase was purified from the venom of the snake Bothrops alternatus by a combination of gel filtration and ion exchange chromatographies. In SDS-PAGE, the enzyme gave a single band with a molecular mass of 105 kDa which was unaltered in the presence of β -mercaptoethanol, indicating that the protein contained no subunits. There were no cont
Publicado em: 2002