Biopharmaceutics Classification System
Mostrando 1-12 de 14 artigos, teses e dissertações.
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1. Challenges to improve the biopharmaceutical properties of poorly water-soluble drugs and the application of the solid dispersion technology
ABSTRACT The oral solid dosage forms are extremely relevant to drug therapy and responsible for much of the pharmaceutical industry turnover worldwide. However, the development of medicines in solid form involves significant challenges, including obtaining formulations with appropriate bioavailability for low aqueous solubility drugs (classes II and IV of th
Matéria (Rio J.). Publicado em: 06/12/2018
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2. Solubility evaluation of didanosine: a comparison between the equilibrium method and intrinsic dissolution for biopharmaceutics classification purposes
ABSTRACT BCS (Biopharmaceutics Classification System) and BDDCS (Biopharmaceutics Drug Disposition Classification System) were proposed as tools for classifying drugs into four categories. Both systems consider the solubility as an important characteristic for the classification of compounds in drug development and in vivo disposition prediction. Although so
Braz. J. Pharm. Sci.. Publicado em: 07/08/2017
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3. Biopharmaceutics classification system: importance and inclusion in biowaiver guidance
O tratamento farmacológico é essencial frente a várias patologias e é fundamental que a política de medicamentos tenha por objetivo oferecer à população tratamento seguro, eficaz e de preço acessível. Uma forma de alcançar esse objetivo é por meio da bioisenção, definida como a substituição de estudos de bioequivalência in vivo por estudos i
Braz. J. Pharm. Sci.. Publicado em: 2015-03
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4. Avaliação do impacto de diferentes variáveis no ensaio de dissolução intrínseca de metronidazol / Evaluation of the impact of different variables in the intrinsic dissolution test for metronidazole
O objetivo do presente trabalho foi avaliar o impacto de diferentes variáveis no ensaio de dissolução intrínseca de metronidazol. Inicialmente, as amostras, com diferentes graus de micronização, foram submetidas à caracterização físico-química, sendo realizados ensaios de solubilidade, tamanho de partícula, análise térmica (DSC/ TG), infraverme
IBICT - Instituto Brasileiro de Informação em Ciência e Tecnologia. Publicado em: 30/03/2011
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5. Validación de un método analítico empleando cromatografía líquida de alta eficiencia para la determinación de ibuprofeno en medios biorrelevantes
An analytical method by liquid chromatography has been proposed and validated to study the apparent solubility of ibuprofen in biorelevant dissolution media. The main properties of the studied media were pH values of 5.0 and 6.5 and the presence or absence of some natural surfactant agents. The parameters evaluated were specificity, linearity, precision, acc
Química Nova. Publicado em: 2010
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6. Avaliação dos critérios de isenção de estudos de bioequivalência in vivo para medicamentos orais em forma farmacêutica sólida de liberação imediata / Evaluation of the criteria for waiving immediate release solid oral dosage forms of in vivo bioequivalence studies
Com a nova lei dos genéricos instituída no Brasil, as indústrias que quiserem fabricá-los deverão comprovar a intercambialidade destes com os medicamentos de referência através de estudos de bioequivalência. Visando reduzir a necessidade dos mesmos por serem onerosos e exporem voluntários sadios aos testes, a Agência Nacional de Vigilância Sanitá
Publicado em: 2010
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7. Development and characterization of nimodipine solid dispersions of PEG 6000 or Poloxamer 407 / Desenvolvimento e caracterização de dispersões sólidas de nimodipino empregando PEG 6000 ou Poloxamer 407
Nimodipine is a calcium blocker, used in prevention and treatment of ischaemic neurological deficits after aneurismal subarachnoid hemorrhage and cognitive deficit. It exhibits a low solubility in water and it is classified as class two in the Biopharmaceutics Classification System (BCS), thereby dissolution is the ratelimiting step in absorption, which impa
Publicado em: 2010
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8. Sistema de classificação biofarmacêutica e bioisenções / Biopharmaceutics classification system and biowaivers
A absorção oral de um fármaco é fundamentalmente dependente da solubilidade aquosa e da permeabilidade gastrintestinal. Estes são fatores determinantes da biodisponibilidade e, consequentemente, da eficácia clínica de um medicamento. O Sistema de Classificação Biofarmacêutica (SCB), fundamentado nas propriedades de solubilidade e permeabilidade, co
Publicado em: 2009
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9. Prediction of Solubility and Permeability Class Membership: Provisional BCS Classification of the World’s Top Oral Drugs
The Biopharmaceutics Classification System (BCS) categorizes drugs into one of four biopharmaceutical classes according to their water solubility and membrane permeability characteristics and broadly allows the prediction of the rate-limiting step in the intestinal absorption process following oral administration. Since its introduction in 1995, the BCS has
Springer US.
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10. Permeation of Four Oral Drugs Through Human Intestinal Mucosa
The pharmaceutical industry is in need of rapid and accurate methods to screen new drug leads for intestinal permeability potential in the early stages of drug discovery. Excised human jejunal mucosa was used to investigate the permeability of the small intestine to four oral drugs, using a flow-through diffusion system. The four drugs were selected as repre
Springer US.
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11. Generalization of a prototype intelligent hybrid system for hard gelatin capsule formulation development
The aim of this project was to expand a previously developed prototype expert network for use in the analysis of multiple biopharmaceutics classification system (BCS) class II drugs. The model drugs used were carbamazepine, chlorpropamide, diazepam, ibuprofen, ketoprofen, naproxen, and piroxicam. Recommended formulations were manufactured and tested for diss
Springer-Verlag.
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12. An Investigation into the Importance of “Very Rapid Dissolution” Criteria for Drug Bioequivalence Demonstration using Gastrointestinal Simulation Technology
The Biopharmaceutics Classification System (BCS) is based on the mechanistic assumptions that the rate and extent of oral drug absorption are governed by drug solubility, intestinal permeability, and dissolution rate from the dosage form administered. One of the goals of BCS is to identify classes of drugs for which bioequivalence may be established based so
Springer US.